Protective Role of Genistein in Acute Liver Damage Induced by Carbon Tetrachloride
Aim. In the present study, we investigated the protective effect of genistein in experimental acute liver damage induced by CCl4. Method. Forty rats were equally allocated to 5 groups. The first group was designated as the control group (group 1). The second group...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2007-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2007/36381 |
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| Summary: | Aim. In the present study, we investigated the protective
effect of genistein in experimental acute liver damage induced by
CCl4.
Method. Forty rats were equally allocated to 5 groups. The
first group was designated as the control group (group 1). The second group
was injected with intraperitoneal CCl4 for 3 days (group 2). The third group was injected
with subcutaneous 1 mg/kg genistein for 4 days starting one
day before CCl4 injection. The fourth group was injected with
intraperitoneal CCl4 for 7 days. The fifth group was injected with
subcutaneous 1 mg/kg genistein for 8 days starting one day before
CCl4 injection. Plasma and liver tissue
malondialdehyde (MDA) and liver glutathione levels, as well as AST
and ALT levels were studied. A histopathological examination was conducted.
Results. Liver tissue MDA levels were found significantly
lower in group 3, in comparison to group 2 (P<.05). Liver tissue MDA level in group 5 was significantly lower
than that in group 4
(P<.001).
Liver tissue glutathione levels were higher in group 5 and 3, relative
to groups 4 and 2, respectively
(P>.05 for each). Inflammation and focal necrosis decreased in
group 3, in comparison to group 2 (P<.001 for each). Inflammation and focal necrosis in group
5 was lower than that in group 4
(P<.001). Actin expression decreased significantly in group 5, relative to group 4
(P<.05).
Conclusion. Genistein has anti-inflammatory and antinecrotic
effects on experimental liver damage caused by CCl4. Genistein reduces liver damage by
preventing lipid peroxidation and strengthening antioxidant systems. |
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| ISSN: | 0962-9351 1466-1861 |