In Vitro Study of Mutagenesis Induced by Crocidolite-Exposed Alveolar Macrophages NR8383 in Cocultured Big Blue Rat2 Embryonic Fibroblasts

In Vitro Study of Mutagenesis Induced by Crocidolite-Exposed Alveolar Macrophages NR8383 in Cocultured Big Blue Rat2 Embryonic Fibroblasts

Asbestos-induced mutagenicity in the lung may involve reactive oxygen/nitrogen species (ROS/RNS) released by alveolar macrophages. With the aim of proposing an alternative in vitro mutagenesis test, a coculture system of rat alveolar macrophages (NR8383) and transgenic Big Blue Rat2 embryonic fibrob...

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Bibliographic Details
Main Authors:	Yves Guichard, Laurent Gaté, Christian Darne, Marie-Claire Bottin, Cristina Langlais, Jean-Claude Micillino, Michèle Goutet, Schmit Julien, Binet Stéphane
Format:	Article
Language:	English
Published:	Wiley 2010-01-01
Series:	Journal of Toxicology
Online Access:	http://dx.doi.org/10.1155/2010/323828
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