Transgenerational inheritance of diabetes susceptibility in male offspring with maternal androgen exposure

Transgenerational inheritance of diabetes susceptibility in male offspring with maternal androgen exposure

Abstract Androgen exposure (AE) poses a profound health threat to women, yet its transgenerational impacts on male descendants remain unclear. Here, employing a large-scale mother-child cohort, we show that maternal hyperandrogenism predisposes sons to β-cell dysfunction. Male offspring mice with pr...

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Main Authors: Yuqing Zhang, Shourui Hu, Shan Han, Congcong Liu, Xiaofan Liang, Yuxuan Li, Zongxuan Lin, Yiming Qin, Chunxuan Geng, Yue Liu, Linlin Cui, Jingmei Hu, Changming Zhang, Zhao Wang, Xin Liu, Jinlong Ma, Zi-Jiang Chen, Han Zhao
Format: Article
Language:English
Published: Nature Publishing Group 2025-02-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-025-00769-1
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