Choroidal thickness in patients with coronary artery disease.
<h4>Purpose</h4>To evaluate choroidal thickness (CTh) in patients with coronary artery disease (CAD) compared to healthy controls.<h4>Design</h4>Cross-sectional.<h4>Methods</h4>Setting: Ambulatory clinic of a large city hospital. Patient population: Thirty-four pa...
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0175691&type=printable |
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| author | Meleha Ahmad Patrick A Kaszubski Lucy Cobbs Harmony Reynolds Roland Theodore Smith |
| author_facet | Meleha Ahmad Patrick A Kaszubski Lucy Cobbs Harmony Reynolds Roland Theodore Smith |
| author_sort | Meleha Ahmad |
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| description | <h4>Purpose</h4>To evaluate choroidal thickness (CTh) in patients with coronary artery disease (CAD) compared to healthy controls.<h4>Design</h4>Cross-sectional.<h4>Methods</h4>Setting: Ambulatory clinic of a large city hospital. Patient population: Thirty-four patients had documented CAD, defined as history of >50% obstruction in at least one coronary artery on cardiac catheterization, positive stress test, ST elevation myocardial infarction, or revascularization procedure. Twenty-eight age-matched controls had no self-reported history of CAD or diabetes. Patients with high myopia, dense cataracts, and retinal disease were excluded. Observation procedures: Enhanced depth imaging optical coherence tomography and questionnaire regarding medical and ocular history. Main outcome measures: Subfoveal CTh and CTh 2000 μm superior, inferior, nasal, and temporal to the fovea in the left eye, measured by 2 readers.<h4>Results</h4>CTh was significantly lower in patients with CAD compared to controls at the subfoveal location (252 vs. 303 μm, P = 0.002) and at all 4 cardinal macular locations. The mean difference in CTh between the 2 groups ranged from 46 to 75 μm and was greatest in the inferior location. Within the CAD group, CTh was significantly lower temporally (P = 0.007) and nasally (P<0.001) than subfoveally, consistent with the pattern observed in controls. On multivariate analysis, CAD was negatively associated with subfoveal CTh (P = 0.006) after controlling for diabetes, hypertension, and hypercholesterolemia.<h4>Conclusions and relevance</h4>Patients with CAD have a thinner macular choroid than controls, with preservation of the normal spatial CTh pattern. Decreased CTh might predispose patients with CAD to high-risk phenotypes of age-related macular degeneration such as reticular pseudodrusen and could serve as a potential biomarker of disease in CAD. |
| format | Article |
| id | doaj-art-2f0b87fc421348cf9bcbd389dbacc382 |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj-art-2f0b87fc421348cf9bcbd389dbacc3822025-08-20T03:13:19ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01126e017569110.1371/journal.pone.0175691Choroidal thickness in patients with coronary artery disease.Meleha AhmadPatrick A KaszubskiLucy CobbsHarmony ReynoldsRoland Theodore Smith<h4>Purpose</h4>To evaluate choroidal thickness (CTh) in patients with coronary artery disease (CAD) compared to healthy controls.<h4>Design</h4>Cross-sectional.<h4>Methods</h4>Setting: Ambulatory clinic of a large city hospital. Patient population: Thirty-four patients had documented CAD, defined as history of >50% obstruction in at least one coronary artery on cardiac catheterization, positive stress test, ST elevation myocardial infarction, or revascularization procedure. Twenty-eight age-matched controls had no self-reported history of CAD or diabetes. Patients with high myopia, dense cataracts, and retinal disease were excluded. Observation procedures: Enhanced depth imaging optical coherence tomography and questionnaire regarding medical and ocular history. Main outcome measures: Subfoveal CTh and CTh 2000 μm superior, inferior, nasal, and temporal to the fovea in the left eye, measured by 2 readers.<h4>Results</h4>CTh was significantly lower in patients with CAD compared to controls at the subfoveal location (252 vs. 303 μm, P = 0.002) and at all 4 cardinal macular locations. The mean difference in CTh between the 2 groups ranged from 46 to 75 μm and was greatest in the inferior location. Within the CAD group, CTh was significantly lower temporally (P = 0.007) and nasally (P<0.001) than subfoveally, consistent with the pattern observed in controls. On multivariate analysis, CAD was negatively associated with subfoveal CTh (P = 0.006) after controlling for diabetes, hypertension, and hypercholesterolemia.<h4>Conclusions and relevance</h4>Patients with CAD have a thinner macular choroid than controls, with preservation of the normal spatial CTh pattern. Decreased CTh might predispose patients with CAD to high-risk phenotypes of age-related macular degeneration such as reticular pseudodrusen and could serve as a potential biomarker of disease in CAD.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0175691&type=printable |
| spellingShingle | Meleha Ahmad Patrick A Kaszubski Lucy Cobbs Harmony Reynolds Roland Theodore Smith Choroidal thickness in patients with coronary artery disease. PLoS ONE |
| title | Choroidal thickness in patients with coronary artery disease. |
| title_full | Choroidal thickness in patients with coronary artery disease. |
| title_fullStr | Choroidal thickness in patients with coronary artery disease. |
| title_full_unstemmed | Choroidal thickness in patients with coronary artery disease. |
| title_short | Choroidal thickness in patients with coronary artery disease. |
| title_sort | choroidal thickness in patients with coronary artery disease |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0175691&type=printable |
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