Successful Treatment of Necrotizing Fasciitis and Streptococcal Toxic Shock Syndrome with the Addition of Linezolid
Necrotizing fasciitis is a deep-seated subcutaneous tissue infection that is commonly associated with streptococcal toxic shock syndrome (TSS). Surgical debridement plus penicillin and clindamycin are the current standard of care. We report a case of necrotizing fasciitis and streptococcal TSS where...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2017/5720708 |
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| author | Hana Rac Karine D. Bojikian Jose Lucar Katie E. Barber |
| author_facet | Hana Rac Karine D. Bojikian Jose Lucar Katie E. Barber |
| author_sort | Hana Rac |
| collection | DOAJ |
| description | Necrotizing fasciitis is a deep-seated subcutaneous tissue infection that is commonly associated with streptococcal toxic shock syndrome (TSS). Surgical debridement plus penicillin and clindamycin are the current standard of care. We report a case of necrotizing fasciitis and streptococcal TSS where linezolid was added after a failure to improve with standard therapy. Briefly after isolation of Streptococcus pyogenes from tissue cultures, the patient underwent two surgical debridement procedures and was changed to standard of care therapy. While the patient was hemodynamically stable, the patient’s wounds, leukocytosis, and thrombocytopenia all progressively worsened. After initiation of linezolid, the patient slowly improved clinically. The present report is the first to highlight the role of linezolid in streptococcal necrotizing fasciitis and TSS not improving with standard therapy. |
| format | Article |
| id | doaj-art-2f098685ec774ba2a8b9bdce4237c180 |
| institution | Kabale University |
| issn | 2090-6625 2090-6633 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Infectious Diseases |
| spelling | doaj-art-2f098685ec774ba2a8b9bdce4237c1802025-02-03T07:25:32ZengWileyCase Reports in Infectious Diseases2090-66252090-66332017-01-01201710.1155/2017/57207085720708Successful Treatment of Necrotizing Fasciitis and Streptococcal Toxic Shock Syndrome with the Addition of LinezolidHana Rac0Karine D. Bojikian1Jose Lucar2Katie E. Barber3University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, USAUniversity of Mississippi Medical Center, 2500 North State Street, Jackson, MS, USAUniversity of Mississippi Medical Center, 2500 North State Street, Jackson, MS, USAUniversity of Mississippi School of Pharmacy, 2500 North State Street, Jackson, MS, USANecrotizing fasciitis is a deep-seated subcutaneous tissue infection that is commonly associated with streptococcal toxic shock syndrome (TSS). Surgical debridement plus penicillin and clindamycin are the current standard of care. We report a case of necrotizing fasciitis and streptococcal TSS where linezolid was added after a failure to improve with standard therapy. Briefly after isolation of Streptococcus pyogenes from tissue cultures, the patient underwent two surgical debridement procedures and was changed to standard of care therapy. While the patient was hemodynamically stable, the patient’s wounds, leukocytosis, and thrombocytopenia all progressively worsened. After initiation of linezolid, the patient slowly improved clinically. The present report is the first to highlight the role of linezolid in streptococcal necrotizing fasciitis and TSS not improving with standard therapy.http://dx.doi.org/10.1155/2017/5720708 |
| spellingShingle | Hana Rac Karine D. Bojikian Jose Lucar Katie E. Barber Successful Treatment of Necrotizing Fasciitis and Streptococcal Toxic Shock Syndrome with the Addition of Linezolid Case Reports in Infectious Diseases |
| title | Successful Treatment of Necrotizing Fasciitis and Streptococcal Toxic Shock Syndrome with the Addition of Linezolid |
| title_full | Successful Treatment of Necrotizing Fasciitis and Streptococcal Toxic Shock Syndrome with the Addition of Linezolid |
| title_fullStr | Successful Treatment of Necrotizing Fasciitis and Streptococcal Toxic Shock Syndrome with the Addition of Linezolid |
| title_full_unstemmed | Successful Treatment of Necrotizing Fasciitis and Streptococcal Toxic Shock Syndrome with the Addition of Linezolid |
| title_short | Successful Treatment of Necrotizing Fasciitis and Streptococcal Toxic Shock Syndrome with the Addition of Linezolid |
| title_sort | successful treatment of necrotizing fasciitis and streptococcal toxic shock syndrome with the addition of linezolid |
| url | http://dx.doi.org/10.1155/2017/5720708 |
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