Comparison of single-port inflatable mediastinoscopic esophagectomy and thoracoscopic esophagectomy in patients with esophageal squamous cell carcinoma after neoadjuvant chemoimmunotherapy
Abstract Objective Currently, the application of single-port inflatable mediastinoscopic esophagectomy in patients with locally advanced esophageal squamous cell carcinoma receiving neoadjuvant chemoimmunotherapy is relatively rare. This study aims to compare the clinical efficacy of single-port inf...
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2025-07-01
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| Online Access: | https://doi.org/10.1186/s12885-025-14530-0 |
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| author | Kaishang Zhang Guoqing Zhang Yujin Qiao Peng Zhang Xiaofang Chen Xue Pan Xiangnan Li |
| author_facet | Kaishang Zhang Guoqing Zhang Yujin Qiao Peng Zhang Xiaofang Chen Xue Pan Xiangnan Li |
| author_sort | Kaishang Zhang |
| collection | DOAJ |
| description | Abstract Objective Currently, the application of single-port inflatable mediastinoscopic esophagectomy in patients with locally advanced esophageal squamous cell carcinoma receiving neoadjuvant chemoimmunotherapy is relatively rare. This study aims to compare the clinical efficacy of single-port inflatable mediastinoscopic esophagectomy with that of thoracoscopic esophagectomy for locally advanced esophageal squamous cell carcinoma following neoadjuvant chemoimmunotherapy. Methods We retrospectively analyzed the perioperative data of 118 patients who underwent minimally invasive esophagectomy. Among them, 80 patients underwent thoracoscopy esophagectomy, and 38 patients underwent single-port inflatable mediastinoscopy esophagectomy. The number of mediastinal lymph nodes dissected, incidence of postoperative complications, and survival period were compared between the two groups. Results The results revealed that the number of mediastinal lymph nodes dissected was similar between the two groups (p = 0.185); In terms of postoperative complications, the incidence of pneumonia was significantly lower in the single-port inflatable mediastinoscopic esophagectomy group than in the thoracoscopic esophagectomy group (p = 0.038), but the incidence of hoarseness was higher in the single-port inflatable mediastinoscopic esophagectomy group than in the thoracoscopic esophagectomy group (p = 0.049). Moreover, there were no significant differences in recurrence patterns, overall survival, or disease-free survival between the two groups. Conclusions The results suggest that single-port inflatable mediastinoscopic esophagectomy is a safe and reliable option for patients with locally advanced esophageal squamous cell carcinoma who have received neoadjuvant chemoimmunotherapy. |
| format | Article |
| id | doaj-art-2f048afcb9ad4b2d82e03db73d6a0c35 |
| institution | DOAJ |
| issn | 1471-2407 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
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| series | BMC Cancer |
| spelling | doaj-art-2f048afcb9ad4b2d82e03db73d6a0c352025-08-20T03:03:37ZengBMCBMC Cancer1471-24072025-07-012511910.1186/s12885-025-14530-0Comparison of single-port inflatable mediastinoscopic esophagectomy and thoracoscopic esophagectomy in patients with esophageal squamous cell carcinoma after neoadjuvant chemoimmunotherapyKaishang Zhang0Guoqing Zhang1Yujin Qiao2Peng Zhang3Xiaofang Chen4Xue Pan5Xiangnan Li6Department of Thoracic Surgery and Esophageal Surgery, The First Affiliated Hospital of Zhengzhou UniversityDepartment of Thoracic Surgery and Esophageal Surgery, The First Affiliated Hospital of Zhengzhou UniversityDepartment of Thoracic Surgery and Esophageal Surgery, The First Affiliated Hospital of Zhengzhou UniversityDepartment of Thoracic Surgery and Esophageal Surgery, The First Affiliated Hospital of Zhengzhou UniversityDepartment of Thoracic Surgery, The First Affiliated Hospital of Xinxiang Medical UniversityNursing College of Zhengzhou University, Zhengzhou UniversityDepartment of Thoracic Surgery and Esophageal Surgery, The First Affiliated Hospital of Zhengzhou UniversityAbstract Objective Currently, the application of single-port inflatable mediastinoscopic esophagectomy in patients with locally advanced esophageal squamous cell carcinoma receiving neoadjuvant chemoimmunotherapy is relatively rare. This study aims to compare the clinical efficacy of single-port inflatable mediastinoscopic esophagectomy with that of thoracoscopic esophagectomy for locally advanced esophageal squamous cell carcinoma following neoadjuvant chemoimmunotherapy. Methods We retrospectively analyzed the perioperative data of 118 patients who underwent minimally invasive esophagectomy. Among them, 80 patients underwent thoracoscopy esophagectomy, and 38 patients underwent single-port inflatable mediastinoscopy esophagectomy. The number of mediastinal lymph nodes dissected, incidence of postoperative complications, and survival period were compared between the two groups. Results The results revealed that the number of mediastinal lymph nodes dissected was similar between the two groups (p = 0.185); In terms of postoperative complications, the incidence of pneumonia was significantly lower in the single-port inflatable mediastinoscopic esophagectomy group than in the thoracoscopic esophagectomy group (p = 0.038), but the incidence of hoarseness was higher in the single-port inflatable mediastinoscopic esophagectomy group than in the thoracoscopic esophagectomy group (p = 0.049). Moreover, there were no significant differences in recurrence patterns, overall survival, or disease-free survival between the two groups. Conclusions The results suggest that single-port inflatable mediastinoscopic esophagectomy is a safe and reliable option for patients with locally advanced esophageal squamous cell carcinoma who have received neoadjuvant chemoimmunotherapy.https://doi.org/10.1186/s12885-025-14530-0ESCCNeoadjuvant chemoimmunotherapySpIMETESurgery |
| spellingShingle | Kaishang Zhang Guoqing Zhang Yujin Qiao Peng Zhang Xiaofang Chen Xue Pan Xiangnan Li Comparison of single-port inflatable mediastinoscopic esophagectomy and thoracoscopic esophagectomy in patients with esophageal squamous cell carcinoma after neoadjuvant chemoimmunotherapy BMC Cancer ESCC Neoadjuvant chemoimmunotherapy SpIME TE Surgery |
| title | Comparison of single-port inflatable mediastinoscopic esophagectomy and thoracoscopic esophagectomy in patients with esophageal squamous cell carcinoma after neoadjuvant chemoimmunotherapy |
| title_full | Comparison of single-port inflatable mediastinoscopic esophagectomy and thoracoscopic esophagectomy in patients with esophageal squamous cell carcinoma after neoadjuvant chemoimmunotherapy |
| title_fullStr | Comparison of single-port inflatable mediastinoscopic esophagectomy and thoracoscopic esophagectomy in patients with esophageal squamous cell carcinoma after neoadjuvant chemoimmunotherapy |
| title_full_unstemmed | Comparison of single-port inflatable mediastinoscopic esophagectomy and thoracoscopic esophagectomy in patients with esophageal squamous cell carcinoma after neoadjuvant chemoimmunotherapy |
| title_short | Comparison of single-port inflatable mediastinoscopic esophagectomy and thoracoscopic esophagectomy in patients with esophageal squamous cell carcinoma after neoadjuvant chemoimmunotherapy |
| title_sort | comparison of single port inflatable mediastinoscopic esophagectomy and thoracoscopic esophagectomy in patients with esophageal squamous cell carcinoma after neoadjuvant chemoimmunotherapy |
| topic | ESCC Neoadjuvant chemoimmunotherapy SpIME TE Surgery |
| url | https://doi.org/10.1186/s12885-025-14530-0 |
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