Count-rate management in 131I SPECT/CT calibration
Abstract Background System calibration is essential for accurate SPECT/CT dosimetry. However, count losses due to dead time and pulse pileup may cause calibration errors, in particular for 131I, where high count rates may be encountered. Calibration at low count rates should also be avoided to minim...
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2025-01-01
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| Series: | EJNMMI Physics |
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| Online Access: | https://doi.org/10.1186/s40658-025-00718-7 |
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| author | Staffan Jacobsson Svärd Cecilia Hindorf Joachim N. Nilsson |
| author_facet | Staffan Jacobsson Svärd Cecilia Hindorf Joachim N. Nilsson |
| author_sort | Staffan Jacobsson Svärd |
| collection | DOAJ |
| description | Abstract Background System calibration is essential for accurate SPECT/CT dosimetry. However, count losses due to dead time and pulse pileup may cause calibration errors, in particular for 131I, where high count rates may be encountered. Calibration at low count rates should also be avoided to minimise detrimental effects from e.g. background counts and statistical fluctuations. This paper aims to present experimental data illustrating count-rate dependencies and to propose practical routines to mitigate errors in the 131I calibration procedure without needing advanced analysis tools. Results The sensitivities of two General Electric (GE) Discovery 670 Pro systems were assessed using two Jaszczak phantom geometries. SPECT/CT data were collected over two months, starting with an initial 131I content of > 2 GBq, decaying to approximately 20 MBq. This allowed for a detailed analysis of count losses due to dead time and pulse pileup. From the sensitivity analysis, it was shown that robust calibration was obtained for 131I phantom activities ranging between 250 and 1500 MBq. Conclusions The results show that adequate corrections for dead-time and pulse-pileup counting losses are essential for accurate calibration. It is argued that loss corrections should be based on total spectrum count rates in projections and not only on the 364.5 keV energy window data. The measurement campaigns presented in this paper, using basic tools and equipment, may serve as a model for establishing routines for count-loss corrections as well as for system calibration and regular control of system sensitivity. The data suggest that analysis of source and count concentration in a homogeneous Jaszczak phantom offers robust calibration, whereas analysis of source strength and counts in a delineated phantom insert offers a practical and robust method for regular quality control. |
| format | Article |
| id | doaj-art-2f0478ba287a4e31be04317db6b7997f |
| institution | Kabale University |
| issn | 2197-7364 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SpringerOpen |
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| series | EJNMMI Physics |
| spelling | doaj-art-2f0478ba287a4e31be04317db6b7997f2025-01-26T12:53:07ZengSpringerOpenEJNMMI Physics2197-73642025-01-0112111910.1186/s40658-025-00718-7Count-rate management in 131I SPECT/CT calibrationStaffan Jacobsson Svärd0Cecilia Hindorf1Joachim N. Nilsson2Department of Medical Radiation Physics and Nuclear Medicine, Karolinska University HospitalDepartment of Medical Radiation Physics and Nuclear Medicine, Karolinska University HospitalDepartment of Medical Radiation Physics and Nuclear Medicine, Karolinska University HospitalAbstract Background System calibration is essential for accurate SPECT/CT dosimetry. However, count losses due to dead time and pulse pileup may cause calibration errors, in particular for 131I, where high count rates may be encountered. Calibration at low count rates should also be avoided to minimise detrimental effects from e.g. background counts and statistical fluctuations. This paper aims to present experimental data illustrating count-rate dependencies and to propose practical routines to mitigate errors in the 131I calibration procedure without needing advanced analysis tools. Results The sensitivities of two General Electric (GE) Discovery 670 Pro systems were assessed using two Jaszczak phantom geometries. SPECT/CT data were collected over two months, starting with an initial 131I content of > 2 GBq, decaying to approximately 20 MBq. This allowed for a detailed analysis of count losses due to dead time and pulse pileup. From the sensitivity analysis, it was shown that robust calibration was obtained for 131I phantom activities ranging between 250 and 1500 MBq. Conclusions The results show that adequate corrections for dead-time and pulse-pileup counting losses are essential for accurate calibration. It is argued that loss corrections should be based on total spectrum count rates in projections and not only on the 364.5 keV energy window data. The measurement campaigns presented in this paper, using basic tools and equipment, may serve as a model for establishing routines for count-loss corrections as well as for system calibration and regular control of system sensitivity. The data suggest that analysis of source and count concentration in a homogeneous Jaszczak phantom offers robust calibration, whereas analysis of source strength and counts in a delineated phantom insert offers a practical and robust method for regular quality control.https://doi.org/10.1186/s40658-025-00718-7SPECT/CT131IQuantificationCalibrationDosimetry |
| spellingShingle | Staffan Jacobsson Svärd Cecilia Hindorf Joachim N. Nilsson Count-rate management in 131I SPECT/CT calibration EJNMMI Physics SPECT/CT 131I Quantification Calibration Dosimetry |
| title | Count-rate management in 131I SPECT/CT calibration |
| title_full | Count-rate management in 131I SPECT/CT calibration |
| title_fullStr | Count-rate management in 131I SPECT/CT calibration |
| title_full_unstemmed | Count-rate management in 131I SPECT/CT calibration |
| title_short | Count-rate management in 131I SPECT/CT calibration |
| title_sort | count rate management in 131i spect ct calibration |
| topic | SPECT/CT 131I Quantification Calibration Dosimetry |
| url | https://doi.org/10.1186/s40658-025-00718-7 |
| work_keys_str_mv | AT staffanjacobssonsvard countratemanagementin131ispectctcalibration AT ceciliahindorf countratemanagementin131ispectctcalibration AT joachimnnilsson countratemanagementin131ispectctcalibration |