Knowledge, attitudes, and practices of healthcare providers toward ADR reporting regarding thiopurine drugs for the treatment of acute lymphoblastic leukemia at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia
BackgroundKnowledge, attitudes, and practices (KAP) regarding the use of thiopurine chemotherapeutic drugs in the treatment of acute lymphoblastic leukemia (ALL) are critical for healthcare professionals. Thiopurines are associated with varying levels of toxicity, including myelosuppression, hepatot...
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Frontiers Media S.A.
2025-05-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1486415/full |
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| author | Eyuel Kassa Mastewal Birhan Mulugeta Ayalew Aschalew Gelaw Abdulkader Mohamedsaid Gidey Degalem Tilahun Worku Awole Mekonen Ermias Teklehaimanot Assefa Asnakew Alazar Amare Nega Berhane Tessemma |
| author_facet | Eyuel Kassa Mastewal Birhan Mulugeta Ayalew Aschalew Gelaw Abdulkader Mohamedsaid Gidey Degalem Tilahun Worku Awole Mekonen Ermias Teklehaimanot Assefa Asnakew Alazar Amare Nega Berhane Tessemma |
| author_sort | Eyuel Kassa |
| collection | DOAJ |
| description | BackgroundKnowledge, attitudes, and practices (KAP) regarding the use of thiopurine chemotherapeutic drugs in the treatment of acute lymphoblastic leukemia (ALL) are critical for healthcare professionals. Thiopurines are associated with varying levels of toxicity, including myelosuppression, hepatotoxicity, and gastrointestinal intolerance. Approximately 20% of ALL patients discontinue thiopurine therapy due to toxicity and other adverse events. This study aims to assess the KAP of healthcare providers (HCPs) concerning thiopurine drugs used in the treatment of ALL in hospital wards in Northwestern Ethiopia.MethodsA hospital-based cross-sectional study was conducted among 161 HCPs at the University of Gondar Comprehensive Specialized Hospital from June 1, 2023, to August 30, 2023. Data were collected using a self-administered questionnaire. The collected data were coded, entered and analyzed using SPSS version 25. Associations between categorical variables were assessed using cross tabulation, and both crude and adjusted odds ratios were calculated with a 95% confidence interval. Variables with p-values less than 0.05 were considered statistically significant.ResultsA total of 161 HCPs participated in the study, comprising 69 (42.9%) females and 92 (57.1%) males. The majority of participants were nurses 105 (65%), followed by physicians 20 (12.4%), pharmacists 19 (11.8%), midwives 10 (6.2%), and health officers 7 (4.3%). More than half of the participants demonstrated inadequate knowledge 94 (58.4%), negative attitudes 82 (50.9%), and poor practices 90 (55.9%) regarding the use of thiopurine drugs for the treatment of ALL. Approximately 50 (31.1%) participants understood the term “thiopurine drugs,” while 89 (55.3%) were aware of their adverse drug reactions. However, the majority 136 (84.5%) had not received training on how to report adverse drug reactions.ConclusionThe majority of healthcare professionals demonstrated negative attitudes, inadequate knowledge, and poor practices concerning the reporting of adverse drug reactions associated with thiopurine drugs. |
| format | Article |
| id | doaj-art-2eff889be8144fd2ac93c4062d136399 |
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| issn | 1663-9812 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Pharmacology |
| spelling | doaj-art-2eff889be8144fd2ac93c4062d1363992025-08-20T01:52:21ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-05-011610.3389/fphar.2025.14864151486415Knowledge, attitudes, and practices of healthcare providers toward ADR reporting regarding thiopurine drugs for the treatment of acute lymphoblastic leukemia at the University of Gondar Comprehensive Specialized Hospital, Northwest EthiopiaEyuel Kassa0Mastewal Birhan1Mulugeta Ayalew2Aschalew Gelaw3Abdulkader Mohamedsaid Gidey4Degalem Tilahun Worku5Awole Mekonen6Ermias Teklehaimanot7Assefa Asnakew8Alazar Amare9Nega Berhane Tessemma10Department of Medical Biotechnology, Institute of Biotechnology, University of Gondar, Gondar, EthiopiaCollege of Veterinary Medicine and Animal Sciences, University of Gondar, Gondar, EthiopiaUnit of Pediatric Hematology Oncology, Department of Pediatrics and Child Health, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, EthiopiaDepartment of Medical Microbiology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, EthiopiaUnit of Pediatric Hematology Oncology, Department of Pediatrics and Child Health, School of Medicine, College of Medicine and Health Sciences, Addis Ababa University, Addis Ababa, EthiopiaUnit of Pediatric Hematology Oncology, Department of Pediatrics and Child Health, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, EthiopiaDepartment of pathology, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, EthiopiaDepartment of Pharmacy, Asrat Woldeyes Health Science Campus, Debre Berhan University, Debre Berhan, EthiopiaUnit of Molecular Biology and Bioinformatics, Institute of Biotechnology, Addis Ababa University, Addis Ababa, EthiopiaMedical Laboratory Department, Dilla University College of Medicine and Health Sciences, Dilla, EthiopiaDepartment of Medical Biotechnology, Institute of Biotechnology, University of Gondar, Gondar, EthiopiaBackgroundKnowledge, attitudes, and practices (KAP) regarding the use of thiopurine chemotherapeutic drugs in the treatment of acute lymphoblastic leukemia (ALL) are critical for healthcare professionals. Thiopurines are associated with varying levels of toxicity, including myelosuppression, hepatotoxicity, and gastrointestinal intolerance. Approximately 20% of ALL patients discontinue thiopurine therapy due to toxicity and other adverse events. This study aims to assess the KAP of healthcare providers (HCPs) concerning thiopurine drugs used in the treatment of ALL in hospital wards in Northwestern Ethiopia.MethodsA hospital-based cross-sectional study was conducted among 161 HCPs at the University of Gondar Comprehensive Specialized Hospital from June 1, 2023, to August 30, 2023. Data were collected using a self-administered questionnaire. The collected data were coded, entered and analyzed using SPSS version 25. Associations between categorical variables were assessed using cross tabulation, and both crude and adjusted odds ratios were calculated with a 95% confidence interval. Variables with p-values less than 0.05 were considered statistically significant.ResultsA total of 161 HCPs participated in the study, comprising 69 (42.9%) females and 92 (57.1%) males. The majority of participants were nurses 105 (65%), followed by physicians 20 (12.4%), pharmacists 19 (11.8%), midwives 10 (6.2%), and health officers 7 (4.3%). More than half of the participants demonstrated inadequate knowledge 94 (58.4%), negative attitudes 82 (50.9%), and poor practices 90 (55.9%) regarding the use of thiopurine drugs for the treatment of ALL. Approximately 50 (31.1%) participants understood the term “thiopurine drugs,” while 89 (55.3%) were aware of their adverse drug reactions. However, the majority 136 (84.5%) had not received training on how to report adverse drug reactions.ConclusionThe majority of healthcare professionals demonstrated negative attitudes, inadequate knowledge, and poor practices concerning the reporting of adverse drug reactions associated with thiopurine drugs.https://www.frontiersin.org/articles/10.3389/fphar.2025.1486415/fullknowledgeattitudepracticeacute lymphoblastic leukemiathiopurine drugsadverse drug reactions |
| spellingShingle | Eyuel Kassa Mastewal Birhan Mulugeta Ayalew Aschalew Gelaw Abdulkader Mohamedsaid Gidey Degalem Tilahun Worku Awole Mekonen Ermias Teklehaimanot Assefa Asnakew Alazar Amare Nega Berhane Tessemma Knowledge, attitudes, and practices of healthcare providers toward ADR reporting regarding thiopurine drugs for the treatment of acute lymphoblastic leukemia at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia Frontiers in Pharmacology knowledge attitude practice acute lymphoblastic leukemia thiopurine drugs adverse drug reactions |
| title | Knowledge, attitudes, and practices of healthcare providers toward ADR reporting regarding thiopurine drugs for the treatment of acute lymphoblastic leukemia at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia |
| title_full | Knowledge, attitudes, and practices of healthcare providers toward ADR reporting regarding thiopurine drugs for the treatment of acute lymphoblastic leukemia at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia |
| title_fullStr | Knowledge, attitudes, and practices of healthcare providers toward ADR reporting regarding thiopurine drugs for the treatment of acute lymphoblastic leukemia at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia |
| title_full_unstemmed | Knowledge, attitudes, and practices of healthcare providers toward ADR reporting regarding thiopurine drugs for the treatment of acute lymphoblastic leukemia at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia |
| title_short | Knowledge, attitudes, and practices of healthcare providers toward ADR reporting regarding thiopurine drugs for the treatment of acute lymphoblastic leukemia at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia |
| title_sort | knowledge attitudes and practices of healthcare providers toward adr reporting regarding thiopurine drugs for the treatment of acute lymphoblastic leukemia at the university of gondar comprehensive specialized hospital northwest ethiopia |
| topic | knowledge attitude practice acute lymphoblastic leukemia thiopurine drugs adverse drug reactions |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1486415/full |
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