Cell retention in scalable, perfusion-based mesenchymal stem cell expansion processes: a proof of concept

Cell retention in scalable, perfusion-based mesenchymal stem cell expansion processes: a proof of concept

The production of clinically relevant quantities of human mesenchymal stromal cells (hMSCs) requires scalable and intensified manufacturing processes. For this reason, the applicability of alternating tangential flow filtration (ATF) and tangential flow depth filtration (TFDF) based cell retention s...

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Bibliographic Details
Main Authors: Samuel Lukas Schneider, Abiram Gopalakrishnan, Misha Alexander Teale, Regine Eibl
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
alternating tangential flow filtration (ATF)
tangential flow filtration (TFF)
microcarrier
hMSC
perfusion
stirred tank bioreactor
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2025.1611703/full
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