Atopic condition of the esophagus - eosinophilic esophagitis - literature review
Introduction and purpose Eosinophilic esophagitis (EoE) is a chronic, immune-mediated disorder causing esophageal dysfunction in children and adults. Characterized by eosinophilic inflammation, EoE leads to dysphagia, food impaction, and esophageal remodeling. Since its classification in the...
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| Format: | Article |
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Kazimierz Wielki University
2025-04-01
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| Series: | Journal of Education, Health and Sport |
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| Online Access: | https://apcz.umk.pl/JEHS/article/view/59373 |
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| author | Artur Pastuszka Karolina Serwońska Aleksandra Galanty-Ochyra Jan Węgrzyn Adam Czarnecki Olga Jabłońska Piotr Zając Łukasz Fijałkowski Aleksandra Nosal |
| author_facet | Artur Pastuszka Karolina Serwońska Aleksandra Galanty-Ochyra Jan Węgrzyn Adam Czarnecki Olga Jabłońska Piotr Zając Łukasz Fijałkowski Aleksandra Nosal |
| author_sort | Artur Pastuszka |
| collection | DOAJ |
| description |
Introduction and purpose
Eosinophilic esophagitis (EoE) is a chronic, immune-mediated disorder causing esophageal dysfunction in children and adults. Characterized by eosinophilic inflammation, EoE leads to dysphagia, food impaction, and esophageal remodeling. Since its classification in the 1990s, research has expanded, yet aspects of its pathogenesis, diagnosis, and management remain under investigation. This review compiles current knowledge on EoE, covering its pathophysiology, epidemiology, clinical presentation, diagnosis, treatment, and prognosis. By integrating recent findings and guidelines, it aims to enhance understanding and optimize care.
Description of the state of knowledge
EoE is defined by eosinophilic infiltration of the esophageal mucosa, leading to dysfunction. Diagnosis relies on histologic criteria, with ≥15 eosinophils per high-power field in biopsies. Endoscopic tools like the EoE Endoscopic Reference Score (EREFS) aid evaluation, though differentiation from GERD remains challenging.
Treatment includes dietary modifications, pharmacologic therapy, and endoscopic interventions. First-line options are dietary elimination, proton pump inhibitors (PPIs), and topical corticosteroids, while emerging biologics target inflammatory pathways. Endoscopic dilation is reserved for fibrostenotic cases.
Despite therapeutic advancements, EoE is a chronic condition requiring long-term management. Continued research is needed to refine treatment strategies and improve outcomes.
Conclusions
EoE requires lifelong management. While dietary, pharmacologic, and endoscopic treatments control symptoms, they do not halt disease progression. Biologic therapies offer promising advances, but further studies are needed to optimize long-term strategies and patient care.
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| format | Article |
| id | doaj-art-2ef89b7412d54df3a8cb9d69a648f341 |
| institution | OA Journals |
| issn | 2391-8306 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj-art-2ef89b7412d54df3a8cb9d69a648f3412025-08-20T01:56:01ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062025-04-018010.12775/JEHS.2025.80.59373Atopic condition of the esophagus - eosinophilic esophagitis - literature reviewArtur Pastuszka0https://orcid.org/0009-0008-6226-9861Karolina Serwońska1https://orcid.org/0000-0003-0958-9360Aleksandra Galanty-Ochyra2https://orcid.org/0009-0000-2911-0201Jan Węgrzyn3https://orcid.org/0009-0008-0548-408XAdam Czarnecki4https://orcid.org/0009-0003-8090-0171Olga Jabłońska5https://orcid.org/0009-0000-3829-6482Piotr Zając6https://orcid.org/0009-0004-1516-8487Łukasz Fijałkowski7https://orcid.org/0009-0009-9088-7461Aleksandra Nosal8https://orcid.org/0009-0007-3043-9494St. Elizabeth Hospital in Katowice, The American Heart of Poland Group, Warszawska 52, 40-008 KatowiceUpper Silesian Medical Center of Prof. Leszek Giec of the Silesian Medical University Ziołowa 45-47, 40-635 Katowice – Ochojec5 Military Clinical Hospital with Polyclinic SPZOZ Wrocławska 1-3, 30-901 KrakówUpper Silesian Medical Center of Prof. Leszek Giec of the Silesian Medical University Ziołowa 45-47, 40-635 Katowice – Ochojec5 Military Clinical Hospital with Polyclinic SPZOZ Wrocławska 1-3, 30-901 KrakówIndependent Public Healthcare Institution of the Ministry of the Interior and Administration in Kraków Kronikarza Galla 25, 30-053 KrakówUpper Silesian Medical Center of Prof. Leszek Giec of the Silesian Medical University Ziołowa 45-47, 40-635 Katowice – Ochojec5 Military Clinical Hospital with Polyclinic SPZOZ Wrocławska 1-3, 30-901 Kraków5 Military Clinical Hospital with Polyclinic SPZOZ Wrocławska 1-3, 30-901 Kraków Introduction and purpose Eosinophilic esophagitis (EoE) is a chronic, immune-mediated disorder causing esophageal dysfunction in children and adults. Characterized by eosinophilic inflammation, EoE leads to dysphagia, food impaction, and esophageal remodeling. Since its classification in the 1990s, research has expanded, yet aspects of its pathogenesis, diagnosis, and management remain under investigation. This review compiles current knowledge on EoE, covering its pathophysiology, epidemiology, clinical presentation, diagnosis, treatment, and prognosis. By integrating recent findings and guidelines, it aims to enhance understanding and optimize care. Description of the state of knowledge EoE is defined by eosinophilic infiltration of the esophageal mucosa, leading to dysfunction. Diagnosis relies on histologic criteria, with ≥15 eosinophils per high-power field in biopsies. Endoscopic tools like the EoE Endoscopic Reference Score (EREFS) aid evaluation, though differentiation from GERD remains challenging. Treatment includes dietary modifications, pharmacologic therapy, and endoscopic interventions. First-line options are dietary elimination, proton pump inhibitors (PPIs), and topical corticosteroids, while emerging biologics target inflammatory pathways. Endoscopic dilation is reserved for fibrostenotic cases. Despite therapeutic advancements, EoE is a chronic condition requiring long-term management. Continued research is needed to refine treatment strategies and improve outcomes. Conclusions EoE requires lifelong management. While dietary, pharmacologic, and endoscopic treatments control symptoms, they do not halt disease progression. Biologic therapies offer promising advances, but further studies are needed to optimize long-term strategies and patient care. https://apcz.umk.pl/JEHS/article/view/59373eosinophilic esophagitisdysphagiaeosinophildupilumab |
| spellingShingle | Artur Pastuszka Karolina Serwońska Aleksandra Galanty-Ochyra Jan Węgrzyn Adam Czarnecki Olga Jabłońska Piotr Zając Łukasz Fijałkowski Aleksandra Nosal Atopic condition of the esophagus - eosinophilic esophagitis - literature review Journal of Education, Health and Sport eosinophilic esophagitis dysphagia eosinophil dupilumab |
| title | Atopic condition of the esophagus - eosinophilic esophagitis - literature review |
| title_full | Atopic condition of the esophagus - eosinophilic esophagitis - literature review |
| title_fullStr | Atopic condition of the esophagus - eosinophilic esophagitis - literature review |
| title_full_unstemmed | Atopic condition of the esophagus - eosinophilic esophagitis - literature review |
| title_short | Atopic condition of the esophagus - eosinophilic esophagitis - literature review |
| title_sort | atopic condition of the esophagus eosinophilic esophagitis literature review |
| topic | eosinophilic esophagitis dysphagia eosinophil dupilumab |
| url | https://apcz.umk.pl/JEHS/article/view/59373 |
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