The possible therapeutic role of advanced glycation end-product inhibitors in ischemic stroke
The advanced glycation end-products (AGEs) are toxic molecules result from non-enzymatic interactions of sugar with lipids or proteins. AGEs promote the generation of reactive oxygen species that induce the release of pro-inflammatory cytokines, and alter the intracellular signaling leading to progr...
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Elsevier
2025-03-01
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| Series: | Brain Research Bulletin |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0361923025000486 |
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| author | Nada H. Aljarba Hayder M. Al-Kuraishy Ali I. Al-Gareeb Mustafa M. Shokr Marios Papadakis Athanasios Alexiou Mubarak Alruwaili Mohammed Alrouji Mohammed S. Alshammari Gaber El-Saber Batiha |
| author_facet | Nada H. Aljarba Hayder M. Al-Kuraishy Ali I. Al-Gareeb Mustafa M. Shokr Marios Papadakis Athanasios Alexiou Mubarak Alruwaili Mohammed Alrouji Mohammed S. Alshammari Gaber El-Saber Batiha |
| author_sort | Nada H. Aljarba |
| collection | DOAJ |
| description | The advanced glycation end-products (AGEs) are toxic molecules result from non-enzymatic interactions of sugar with lipids or proteins. AGEs promote the generation of reactive oxygen species that induce the release of pro-inflammatory cytokines, and alter the intracellular signaling leading to progressive biochemical and metabolic derangements. AGEs-induced cellular aging is implicated in the development and progression of different neurological disorders such as dementia, neuropsychiatric disorders, and cerebrovascular diseases. Particularly, AGEs-induced microangiopathy and macroangiopathy trigger the induction of prothrombotic/thrombotic cascades with subsequent increase risk of acute ischemic stroke (AIS). Many studies highlighted that AGEs serum levels are correlated with the incidence, pathogenicity, and severity of AIS. However, the relationship between AGEs and AIS is not elucidated completely. Therefore, this review aims to discuss how AGEs promote the development and progression of AIS, and how AGEs inhibitors could be effective in the management of AIS. |
| format | Article |
| id | doaj-art-2ef13dd2efc14008af84306f5e3290d6 |
| institution | Kabale University |
| issn | 1873-2747 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Research Bulletin |
| spelling | doaj-art-2ef13dd2efc14008af84306f5e3290d62025-02-07T04:46:49ZengElsevierBrain Research Bulletin1873-27472025-03-01222111236The possible therapeutic role of advanced glycation end-product inhibitors in ischemic strokeNada H. Aljarba0Hayder M. Al-Kuraishy1Ali I. Al-Gareeb2Mustafa M. Shokr3Marios Papadakis4Athanasios Alexiou5Mubarak Alruwaili6Mohammed Alrouji7Mohammed S. Alshammari8Gaber El-Saber Batiha9Department of Biology, College of science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi ArabiaDepartment of Clinical Pharmacology and Medicine, College of Medicine, Mustansiriyah University, Baghdad 14132, IraqDepartment of Clinical Pharmacology and Medicine, College of Medicine Jabir ibn Hayyan Medical University, Al-Ameer Qu., Najaf, IraqDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Sinai University– Arish Branch, Arish 45511, EgyptUniversity Hospital Witten-Herdecke, University of Witten-Herdecke, Heusnerstrasse 40, Wuppertal, 42283, Germany; Corresponding authors.University Centre for Research & Development, Chandigarh University, Mohali, India; Department of Research & Development, Funogen, Athens, GreeceDepartment of Internal Medicine, College of Medicine, Jouf University, Sakaka, Saudi ArabiaDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Shaqra University, Shaqra 11961, Saudi Arabia; Corresponding authors.Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Shaqra University, Shaqra 11961, Saudi ArabiaDepartment of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour, AlBeheira 22511, EgyptThe advanced glycation end-products (AGEs) are toxic molecules result from non-enzymatic interactions of sugar with lipids or proteins. AGEs promote the generation of reactive oxygen species that induce the release of pro-inflammatory cytokines, and alter the intracellular signaling leading to progressive biochemical and metabolic derangements. AGEs-induced cellular aging is implicated in the development and progression of different neurological disorders such as dementia, neuropsychiatric disorders, and cerebrovascular diseases. Particularly, AGEs-induced microangiopathy and macroangiopathy trigger the induction of prothrombotic/thrombotic cascades with subsequent increase risk of acute ischemic stroke (AIS). Many studies highlighted that AGEs serum levels are correlated with the incidence, pathogenicity, and severity of AIS. However, the relationship between AGEs and AIS is not elucidated completely. Therefore, this review aims to discuss how AGEs promote the development and progression of AIS, and how AGEs inhibitors could be effective in the management of AIS.http://www.sciencedirect.com/science/article/pii/S0361923025000486Advanced glycation end-productsacute ischemic strokeAGEs inhibitors |
| spellingShingle | Nada H. Aljarba Hayder M. Al-Kuraishy Ali I. Al-Gareeb Mustafa M. Shokr Marios Papadakis Athanasios Alexiou Mubarak Alruwaili Mohammed Alrouji Mohammed S. Alshammari Gaber El-Saber Batiha The possible therapeutic role of advanced glycation end-product inhibitors in ischemic stroke Brain Research Bulletin Advanced glycation end-products acute ischemic stroke AGEs inhibitors |
| title | The possible therapeutic role of advanced glycation end-product inhibitors in ischemic stroke |
| title_full | The possible therapeutic role of advanced glycation end-product inhibitors in ischemic stroke |
| title_fullStr | The possible therapeutic role of advanced glycation end-product inhibitors in ischemic stroke |
| title_full_unstemmed | The possible therapeutic role of advanced glycation end-product inhibitors in ischemic stroke |
| title_short | The possible therapeutic role of advanced glycation end-product inhibitors in ischemic stroke |
| title_sort | possible therapeutic role of advanced glycation end product inhibitors in ischemic stroke |
| topic | Advanced glycation end-products acute ischemic stroke AGEs inhibitors |
| url | http://www.sciencedirect.com/science/article/pii/S0361923025000486 |
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