Chronic Inflammation and Cytokines in the Tumor Microenvironment
Acute inflammation is a response to an alteration induced by a pathogen or a physical or chemical insult, which functions to eliminate the source of the damage and restore homeostasis to the affected tissue. However, chronic inflammation triggers cellular events that can promote malignant transforma...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2014/149185 |
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| author | Glauben Landskron Marjorie De la Fuente Peti Thuwajit Chanitra Thuwajit Marcela A. Hermoso |
| author_facet | Glauben Landskron Marjorie De la Fuente Peti Thuwajit Chanitra Thuwajit Marcela A. Hermoso |
| author_sort | Glauben Landskron |
| collection | DOAJ |
| description | Acute inflammation is a response to an alteration induced by a pathogen or a physical or chemical insult, which functions to eliminate the source of the damage and restore homeostasis to the affected tissue. However, chronic inflammation triggers cellular events that can promote malignant transformation of cells and carcinogenesis. Several inflammatory mediators, such as TNF-α, IL-6, TGF-β, and IL-10, have been shown to participate in both the initiation and progression of cancer. In this review, we explore the role of these cytokines in important events of carcinogenesis, such as their capacity to generate reactive oxygen and nitrogen species, their potential mutagenic effect, and their involvement in mechanisms for epithelial mesenchymal transition, angiogenesis, and metastasis. Finally, we will provide an in-depth analysis of the participation of these cytokines in two types of cancer attributable to chronic inflammatory disease: colitis-associated colorectal cancer and cholangiocarcinoma. |
| format | Article |
| id | doaj-art-2eed1959ce3a41bb8414a6f67e57445a |
| institution | OA Journals |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-2eed1959ce3a41bb8414a6f67e57445a2025-08-20T02:07:53ZengWileyJournal of Immunology Research2314-88612314-71562014-01-01201410.1155/2014/149185149185Chronic Inflammation and Cytokines in the Tumor MicroenvironmentGlauben Landskron0Marjorie De la Fuente1Peti Thuwajit2Chanitra Thuwajit3Marcela A. Hermoso4Disciplinary Program, Institute of Biomedical Sciences, School of Medicine, University of Chile, Independencia 1027, 8380453 Santiago, ChileDisciplinary Program, Institute of Biomedical Sciences, School of Medicine, University of Chile, Independencia 1027, 8380453 Santiago, ChileDepartment of Immunology, School of Medicine, Siriraj Hospital, Mahidol University, 2 Prannok Road, Bangkok Noi, Bangkok 10700, ThailandDepartment of Immunology, School of Medicine, Siriraj Hospital, Mahidol University, 2 Prannok Road, Bangkok Noi, Bangkok 10700, ThailandDisciplinary Program, Institute of Biomedical Sciences, School of Medicine, University of Chile, Independencia 1027, 8380453 Santiago, ChileAcute inflammation is a response to an alteration induced by a pathogen or a physical or chemical insult, which functions to eliminate the source of the damage and restore homeostasis to the affected tissue. However, chronic inflammation triggers cellular events that can promote malignant transformation of cells and carcinogenesis. Several inflammatory mediators, such as TNF-α, IL-6, TGF-β, and IL-10, have been shown to participate in both the initiation and progression of cancer. In this review, we explore the role of these cytokines in important events of carcinogenesis, such as their capacity to generate reactive oxygen and nitrogen species, their potential mutagenic effect, and their involvement in mechanisms for epithelial mesenchymal transition, angiogenesis, and metastasis. Finally, we will provide an in-depth analysis of the participation of these cytokines in two types of cancer attributable to chronic inflammatory disease: colitis-associated colorectal cancer and cholangiocarcinoma.http://dx.doi.org/10.1155/2014/149185 |
| spellingShingle | Glauben Landskron Marjorie De la Fuente Peti Thuwajit Chanitra Thuwajit Marcela A. Hermoso Chronic Inflammation and Cytokines in the Tumor Microenvironment Journal of Immunology Research |
| title | Chronic Inflammation and Cytokines in the Tumor Microenvironment |
| title_full | Chronic Inflammation and Cytokines in the Tumor Microenvironment |
| title_fullStr | Chronic Inflammation and Cytokines in the Tumor Microenvironment |
| title_full_unstemmed | Chronic Inflammation and Cytokines in the Tumor Microenvironment |
| title_short | Chronic Inflammation and Cytokines in the Tumor Microenvironment |
| title_sort | chronic inflammation and cytokines in the tumor microenvironment |
| url | http://dx.doi.org/10.1155/2014/149185 |
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