Effects of Black Cumin Seed Extract on Pancreatic Islet β-Cell Proliferation and Hypoglycemic Activity in Streptozotocin-Induced Diabetic Rats
Thymoquinone (TQ), a bioactive compound derived from black cumin seeds, is renowned for its potent anti-obesity and anti-diabetic properties. Due to the stability challenges of TQ, it has predominantly been utilized in oil formulations. This study aimed to enhance the stability of TQ and investigate...
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MDPI AG
2025-01-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/14/2/174 |
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| author | Jongkyu Kim Yoon-Seok Chun Namkyu Yoon Byungkwon Kim Kiin Choi Sae-Kwang Ku Namju Lee |
| author_facet | Jongkyu Kim Yoon-Seok Chun Namkyu Yoon Byungkwon Kim Kiin Choi Sae-Kwang Ku Namju Lee |
| author_sort | Jongkyu Kim |
| collection | DOAJ |
| description | Thymoquinone (TQ), a bioactive compound derived from black cumin seeds, is renowned for its potent anti-obesity and anti-diabetic properties. Due to the stability challenges of TQ, it has predominantly been utilized in oil formulations. This study aimed to enhance the stability of TQ and investigated the impact of consuming insoluble fiber from black cumin seeds on restoring antioxidant function compromised by diabetes and improving hyperglycemia management. We evaluated the restorative effects of a 35-day administration of black cumin seed extract (BCS) on antioxidant function impaired by streptozotocin (STZ)-induced diabetes, alongside structural and functional alterations in the pancreas, liver, and kidneys. The results demonstrated significant improvements in organ weight, particularly in pancreatic tissue. Moreover, BCS administration markedly suppressed the expression of key genes associated with pancreatic dysfunction and damage, including caspase-3, transforming growth factor-beta 1 (TGF-β1), and interleukin-1 beta (IL-1β). Through oral glucose tolerance tests (OGTTs), BCS was found to effectively regulate chronic hyperglycemia and exhibit potential for managing acute hyperglycemia. These findings suggest that BCS not only addresses both glycemic and non-glycemic complications of diabetes but also offers a safe, long-term solution. Consequently, BCS emerges as a promising therapeutic agent for hyperglycemia management, including in prediabetic stages. |
| format | Article |
| id | doaj-art-2eed018cb8664ebaa2e507150da7c66a |
| institution | DOAJ |
| issn | 2076-3921 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj-art-2eed018cb8664ebaa2e507150da7c66a2025-08-20T03:11:18ZengMDPI AGAntioxidants2076-39212025-01-0114217410.3390/antiox14020174Effects of Black Cumin Seed Extract on Pancreatic Islet β-Cell Proliferation and Hypoglycemic Activity in Streptozotocin-Induced Diabetic RatsJongkyu Kim0Yoon-Seok Chun1Namkyu Yoon2Byungkwon Kim3Kiin Choi4Sae-Kwang Ku5Namju Lee6AriBnC Co., Ltd., Yongin 16914, Republic of KoreaAriBnC Co., Ltd., Yongin 16914, Republic of KoreaAriBnC Co., Ltd., Yongin 16914, Republic of KoreaAriBnC Co., Ltd., Yongin 16914, Republic of KoreaAriBnC Co., Ltd., Yongin 16914, Republic of KoreaDepartment of Anatomy and Histology, College of Korean Medicine, Daegu Haany University, Gyeongsan 38610, Republic of KoreaIntergrative Medicine Innovation Center, Wonkwang University, 460 Iksan-daero, Sindong, Iksan 54538, Republic of KoreaThymoquinone (TQ), a bioactive compound derived from black cumin seeds, is renowned for its potent anti-obesity and anti-diabetic properties. Due to the stability challenges of TQ, it has predominantly been utilized in oil formulations. This study aimed to enhance the stability of TQ and investigated the impact of consuming insoluble fiber from black cumin seeds on restoring antioxidant function compromised by diabetes and improving hyperglycemia management. We evaluated the restorative effects of a 35-day administration of black cumin seed extract (BCS) on antioxidant function impaired by streptozotocin (STZ)-induced diabetes, alongside structural and functional alterations in the pancreas, liver, and kidneys. The results demonstrated significant improvements in organ weight, particularly in pancreatic tissue. Moreover, BCS administration markedly suppressed the expression of key genes associated with pancreatic dysfunction and damage, including caspase-3, transforming growth factor-beta 1 (TGF-β1), and interleukin-1 beta (IL-1β). Through oral glucose tolerance tests (OGTTs), BCS was found to effectively regulate chronic hyperglycemia and exhibit potential for managing acute hyperglycemia. These findings suggest that BCS not only addresses both glycemic and non-glycemic complications of diabetes but also offers a safe, long-term solution. Consequently, BCS emerges as a promising therapeutic agent for hyperglycemia management, including in prediabetic stages.https://www.mdpi.com/2076-3921/14/2/174thymoquinone (TQ)black cumin seed extract (BCS)antioxidant functionstreptozotocin-induced diabeteshyperglycemia management |
| spellingShingle | Jongkyu Kim Yoon-Seok Chun Namkyu Yoon Byungkwon Kim Kiin Choi Sae-Kwang Ku Namju Lee Effects of Black Cumin Seed Extract on Pancreatic Islet β-Cell Proliferation and Hypoglycemic Activity in Streptozotocin-Induced Diabetic Rats Antioxidants thymoquinone (TQ) black cumin seed extract (BCS) antioxidant function streptozotocin-induced diabetes hyperglycemia management |
| title | Effects of Black Cumin Seed Extract on Pancreatic Islet β-Cell Proliferation and Hypoglycemic Activity in Streptozotocin-Induced Diabetic Rats |
| title_full | Effects of Black Cumin Seed Extract on Pancreatic Islet β-Cell Proliferation and Hypoglycemic Activity in Streptozotocin-Induced Diabetic Rats |
| title_fullStr | Effects of Black Cumin Seed Extract on Pancreatic Islet β-Cell Proliferation and Hypoglycemic Activity in Streptozotocin-Induced Diabetic Rats |
| title_full_unstemmed | Effects of Black Cumin Seed Extract on Pancreatic Islet β-Cell Proliferation and Hypoglycemic Activity in Streptozotocin-Induced Diabetic Rats |
| title_short | Effects of Black Cumin Seed Extract on Pancreatic Islet β-Cell Proliferation and Hypoglycemic Activity in Streptozotocin-Induced Diabetic Rats |
| title_sort | effects of black cumin seed extract on pancreatic islet β cell proliferation and hypoglycemic activity in streptozotocin induced diabetic rats |
| topic | thymoquinone (TQ) black cumin seed extract (BCS) antioxidant function streptozotocin-induced diabetes hyperglycemia management |
| url | https://www.mdpi.com/2076-3921/14/2/174 |
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