Role of proteases in oral carcinogenesis: Insights into the cancer degradome and therapeutic implications
Cancer, a major global health concern, claims millions of lives annually, with oral squamous cell carcinoma (OSCC) representing a significant burden. Despite therapeutic advancements, OSCC's morbidity and mortality rates have seen little improvement over decades, necessitating deeper molecular...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-06-01
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| Series: | Oral Oncology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772906024003881 |
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| author | Gargi S. Sarode Sachin C. Sarode Urmi Ghone Rahul Anand |
| author_facet | Gargi S. Sarode Sachin C. Sarode Urmi Ghone Rahul Anand |
| author_sort | Gargi S. Sarode |
| collection | DOAJ |
| description | Cancer, a major global health concern, claims millions of lives annually, with oral squamous cell carcinoma (OSCC) representing a significant burden. Despite therapeutic advancements, OSCC's morbidity and mortality rates have seen little improvement over decades, necessitating deeper molecular understanding for effective treatment strategies. Proteases, essential enzymes regulating crucial cellular processes, emerge as promising targets and diagnostic markers in OSCC. OSCC's intricate pathogenesis involves dysregulation of proteolytic systems, prominently featuring cysteine proteases like cathepsins B and D, serine proteases including trypsin, and matrix metalloproteases (MMPs) such as MMP-9. These proteases drive tumor invasion, angiogenesis, and metastasis by degrading extracellular matrix components and modulating signaling pathways. Moreover, OSCC progression is exacerbated by the loss of protease inhibitors, notably membrane-bound serine protease inhibitor HAI-1. Understanding these proteolytic networks in OSCC offers insights into disease mechanisms and therapeutic avenues. Targeting specific proteases or their inhibitors holds promise for personalized OSCC treatment strategies. Further research into protease involvement in OSCC pathogenesis is warranted to enhance diagnosis, prognosis, and therapeutic outcomes, ultimately alleviating the burden of this devastating disease. |
| format | Article |
| id | doaj-art-2ee8f2f788b7420dbad837a3bbb93fec |
| institution | Kabale University |
| issn | 2772-9060 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Oral Oncology Reports |
| spelling | doaj-art-2ee8f2f788b7420dbad837a3bbb93fec2025-01-09T06:16:41ZengElsevierOral Oncology Reports2772-90602024-06-0110100542Role of proteases in oral carcinogenesis: Insights into the cancer degradome and therapeutic implicationsGargi S. Sarode0Sachin C. Sarode1Urmi Ghone2Rahul Anand3Department of Oral Pathology and Microbiology, Dr. D.Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Sant-Tukaram Nagar, Pimpri Pune, 411018, MH, IndiaDepartment of Oral Pathology and Microbiology, Dr. D.Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Sant-Tukaram Nagar, Pimpri Pune, 411018, MH, India; Dr. D. Y. Patil Unitech Society's Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri Pune, 411018, Maharashtra, India; Corresponding author. Department of Oral Pathology and Microbiology, Dr. D. Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Sant-Tukaram Nagar, Pimpri Pune, 411018, Maharashtra, India.Department of Oral Pathology and Microbiology, D.Y. Patil Dental School, D Y Patil Knowledge City, Charholi Budruk, Lohegaon, Pune, 412 105, MH, IndiaDepartment of Oral Pathology and Microbiology, Dr. D.Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Sant-Tukaram Nagar, Pimpri Pune, 411018, MH, IndiaCancer, a major global health concern, claims millions of lives annually, with oral squamous cell carcinoma (OSCC) representing a significant burden. Despite therapeutic advancements, OSCC's morbidity and mortality rates have seen little improvement over decades, necessitating deeper molecular understanding for effective treatment strategies. Proteases, essential enzymes regulating crucial cellular processes, emerge as promising targets and diagnostic markers in OSCC. OSCC's intricate pathogenesis involves dysregulation of proteolytic systems, prominently featuring cysteine proteases like cathepsins B and D, serine proteases including trypsin, and matrix metalloproteases (MMPs) such as MMP-9. These proteases drive tumor invasion, angiogenesis, and metastasis by degrading extracellular matrix components and modulating signaling pathways. Moreover, OSCC progression is exacerbated by the loss of protease inhibitors, notably membrane-bound serine protease inhibitor HAI-1. Understanding these proteolytic networks in OSCC offers insights into disease mechanisms and therapeutic avenues. Targeting specific proteases or their inhibitors holds promise for personalized OSCC treatment strategies. Further research into protease involvement in OSCC pathogenesis is warranted to enhance diagnosis, prognosis, and therapeutic outcomes, ultimately alleviating the burden of this devastating disease.http://www.sciencedirect.com/science/article/pii/S2772906024003881ProteasesProtease inhibitorsOral squamous cell carcinomaOral cancerMatrix metalloproteinasesTherapeutics |
| spellingShingle | Gargi S. Sarode Sachin C. Sarode Urmi Ghone Rahul Anand Role of proteases in oral carcinogenesis: Insights into the cancer degradome and therapeutic implications Oral Oncology Reports Proteases Protease inhibitors Oral squamous cell carcinoma Oral cancer Matrix metalloproteinases Therapeutics |
| title | Role of proteases in oral carcinogenesis: Insights into the cancer degradome and therapeutic implications |
| title_full | Role of proteases in oral carcinogenesis: Insights into the cancer degradome and therapeutic implications |
| title_fullStr | Role of proteases in oral carcinogenesis: Insights into the cancer degradome and therapeutic implications |
| title_full_unstemmed | Role of proteases in oral carcinogenesis: Insights into the cancer degradome and therapeutic implications |
| title_short | Role of proteases in oral carcinogenesis: Insights into the cancer degradome and therapeutic implications |
| title_sort | role of proteases in oral carcinogenesis insights into the cancer degradome and therapeutic implications |
| topic | Proteases Protease inhibitors Oral squamous cell carcinoma Oral cancer Matrix metalloproteinases Therapeutics |
| url | http://www.sciencedirect.com/science/article/pii/S2772906024003881 |
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