Correlation between dietary acid–base load and chronic kidney disease patients with type 2 diabetes mellitus
ObjectiveThis study aimed to investigate the effect of dietary acid-base load on patients with chronic kidney disease (CKD) and type 2 diabetes mellitus (T2DM).DesignA total of 300 patients with CKD were enrolled and divided into three groups according to DAL tertiles. Dietary intake was assessed us...
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1581009/full |
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| author | Hui Huang Hui Huang Qian Wang Ruimin Zhang Ruimin Zhang Fang Liu Fang Liu Yue Niu Yayong Luo Shuang Li Tao Li Zhengchun Tang Zhengchun Tang Xiaolong Wang Jian Yang Yong Wang Li Zhang Sha Luo Weiguang Zhang Ying Zheng Weizhu Deng Guangyan Cai Xiangmei Chen Xiangmei Chen Xiangmei Chen Zheyi Dong |
| author_facet | Hui Huang Hui Huang Qian Wang Ruimin Zhang Ruimin Zhang Fang Liu Fang Liu Yue Niu Yayong Luo Shuang Li Tao Li Zhengchun Tang Zhengchun Tang Xiaolong Wang Jian Yang Yong Wang Li Zhang Sha Luo Weiguang Zhang Ying Zheng Weizhu Deng Guangyan Cai Xiangmei Chen Xiangmei Chen Xiangmei Chen Zheyi Dong |
| author_sort | Hui Huang |
| collection | DOAJ |
| description | ObjectiveThis study aimed to investigate the effect of dietary acid-base load on patients with chronic kidney disease (CKD) and type 2 diabetes mellitus (T2DM).DesignA total of 300 patients with CKD were enrolled and divided into three groups according to DAL tertiles. Dietary intake was assessed using a 24-h dietary recall, and diet-based acidity was assessed using net endogenous acid production (NEAP), potential renal acid load (PRAL), and dietary acid load (DAL). Multivariable logistic regression models were used to determine the association between diet-based acid load scores and CKD and T2DM.ResultsWithin the food category groupings, the DAL score was positively associated with poultry and eggs and negatively associated with fruits and vegetables. Regarding energy and macronutrients, the DAL score was positively correlated with the intake of protein, animal protein, monounsaturated fatty acids, saturated fatty acids, and fat, while it was negatively correlated with the intake of carbohydrates, plant protein, and dietary fiber. In terms of micronutrients, DAL scores were positively associated with phosphorus intake and negatively associated with potassium, magnesium, and copper intake. After adjusting for age, BMI, energy, and eGFR, and stratifying by sex, logistic regression analysis showed that DAL level (OR = 6.47, 95% CI 1.19–35.18, p = 0.031) was a related factor for CKD and T2DM in females.ConclusionDAL score is a related factor for patients with T2DM and CKD. |
| format | Article |
| id | doaj-art-2ee7015d98bb4e409446c709dfb340f9 |
| institution | OA Journals |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj-art-2ee7015d98bb4e409446c709dfb340f92025-08-20T02:25:44ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-05-011210.3389/fnut.2025.15810091581009Correlation between dietary acid–base load and chronic kidney disease patients with type 2 diabetes mellitusHui Huang0Hui Huang1Qian Wang2Ruimin Zhang3Ruimin Zhang4Fang Liu5Fang Liu6Yue Niu7Yayong Luo8Shuang Li9Tao Li10Zhengchun Tang11Zhengchun Tang12Xiaolong Wang13Jian Yang14Yong Wang15Li Zhang16Sha Luo17Weiguang Zhang18Ying Zheng19Weizhu Deng20Guangyan Cai21Xiangmei Chen22Xiangmei Chen23Xiangmei Chen24Zheyi Dong25Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaState Key Laboratory of Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Preventionand Treatment of Pan-vascular Diseases, Key Disciplines of National Administration of Traditional Chinese Medicine(zyyzdxk-2023310), Department of Nephrology, First Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Kidney Diseases, Beijing, ChinaState Key Laboratory of Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Preventionand Treatment of Pan-vascular Diseases, Key Disciplines of National Administration of Traditional Chinese Medicine(zyyzdxk-2023310), Department of Nephrology, First Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Kidney Diseases, Beijing, ChinaChengdu University of Traditional Chinese Medicine, Chengdu, ChinaState Key Laboratory of Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Preventionand Treatment of Pan-vascular Diseases, Key Disciplines of National Administration of Traditional Chinese Medicine(zyyzdxk-2023310), Department of Nephrology, First Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Kidney Diseases, Beijing, ChinaState Key Laboratory of Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Preventionand Treatment of Pan-vascular Diseases, Key Disciplines of National Administration of Traditional Chinese Medicine(zyyzdxk-2023310), Department of Nephrology, First Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Kidney Diseases, Beijing, ChinaSchool of Clinical Medicine, Guangdong Pharmaceutical University, Guangzhou, ChinaState Key Laboratory of Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Preventionand Treatment of Pan-vascular Diseases, Key Disciplines of National Administration of Traditional Chinese Medicine(zyyzdxk-2023310), Department of Nephrology, First Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Kidney Diseases, Beijing, ChinaState Key Laboratory of Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Preventionand Treatment of Pan-vascular Diseases, Key Disciplines of National Administration of Traditional Chinese Medicine(zyyzdxk-2023310), Department of Nephrology, First Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Kidney Diseases, Beijing, ChinaState Key Laboratory of Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Preventionand Treatment of Pan-vascular Diseases, Key Disciplines of National Administration of Traditional Chinese Medicine(zyyzdxk-2023310), Department of Nephrology, First Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Kidney Diseases, Beijing, ChinaHenan University of Traditional Chinese Medicine, Zhengzhou, ChinaState Key Laboratory of Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Preventionand Treatment of Pan-vascular Diseases, Key Disciplines of National Administration of Traditional Chinese Medicine(zyyzdxk-2023310), Department of Nephrology, First Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Kidney Diseases, Beijing, ChinaSchool of Clinical Medicine, Guangdong Pharmaceutical University, Guangzhou, ChinaState Key Laboratory of Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Preventionand Treatment of Pan-vascular Diseases, Key Disciplines of National Administration of Traditional Chinese Medicine(zyyzdxk-2023310), Department of Nephrology, First Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Kidney Diseases, Beijing, ChinaState Key Laboratory of Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Preventionand Treatment of Pan-vascular Diseases, Key Disciplines of National Administration of Traditional Chinese Medicine(zyyzdxk-2023310), Department of Nephrology, First Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Kidney Diseases, Beijing, ChinaState Key Laboratory of Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Preventionand Treatment of Pan-vascular Diseases, Key Disciplines of National Administration of Traditional Chinese Medicine(zyyzdxk-2023310), Department of Nephrology, First Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Kidney Diseases, Beijing, ChinaState Key Laboratory of Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Preventionand Treatment of Pan-vascular Diseases, Key Disciplines of National Administration of Traditional Chinese Medicine(zyyzdxk-2023310), Department of Nephrology, First Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Kidney Diseases, Beijing, ChinaState Key Laboratory of Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Preventionand Treatment of Pan-vascular Diseases, Key Disciplines of National Administration of Traditional Chinese Medicine(zyyzdxk-2023310), Department of Nephrology, First Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Kidney Diseases, Beijing, ChinaState Key Laboratory of Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Preventionand Treatment of Pan-vascular Diseases, Key Disciplines of National Administration of Traditional Chinese Medicine(zyyzdxk-2023310), Department of Nephrology, First Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Kidney Diseases, Beijing, ChinaState Key Laboratory of Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Preventionand Treatment of Pan-vascular Diseases, Key Disciplines of National Administration of Traditional Chinese Medicine(zyyzdxk-2023310), Department of Nephrology, First Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Kidney Diseases, Beijing, ChinaState Key Laboratory of Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Preventionand Treatment of Pan-vascular Diseases, Key Disciplines of National Administration of Traditional Chinese Medicine(zyyzdxk-2023310), Department of Nephrology, First Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Kidney Diseases, Beijing, ChinaState Key Laboratory of Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Preventionand Treatment of Pan-vascular Diseases, Key Disciplines of National Administration of Traditional Chinese Medicine(zyyzdxk-2023310), Department of Nephrology, First Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Kidney Diseases, Beijing, ChinaChengdu University of Traditional Chinese Medicine, Chengdu, ChinaState Key Laboratory of Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Preventionand Treatment of Pan-vascular Diseases, Key Disciplines of National Administration of Traditional Chinese Medicine(zyyzdxk-2023310), Department of Nephrology, First Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Kidney Diseases, Beijing, ChinaSchool of Clinical Medicine, Guangdong Pharmaceutical University, Guangzhou, ChinaState Key Laboratory of Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Preventionand Treatment of Pan-vascular Diseases, Key Disciplines of National Administration of Traditional Chinese Medicine(zyyzdxk-2023310), Department of Nephrology, First Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Kidney Diseases, Beijing, ChinaObjectiveThis study aimed to investigate the effect of dietary acid-base load on patients with chronic kidney disease (CKD) and type 2 diabetes mellitus (T2DM).DesignA total of 300 patients with CKD were enrolled and divided into three groups according to DAL tertiles. Dietary intake was assessed using a 24-h dietary recall, and diet-based acidity was assessed using net endogenous acid production (NEAP), potential renal acid load (PRAL), and dietary acid load (DAL). Multivariable logistic regression models were used to determine the association between diet-based acid load scores and CKD and T2DM.ResultsWithin the food category groupings, the DAL score was positively associated with poultry and eggs and negatively associated with fruits and vegetables. Regarding energy and macronutrients, the DAL score was positively correlated with the intake of protein, animal protein, monounsaturated fatty acids, saturated fatty acids, and fat, while it was negatively correlated with the intake of carbohydrates, plant protein, and dietary fiber. In terms of micronutrients, DAL scores were positively associated with phosphorus intake and negatively associated with potassium, magnesium, and copper intake. After adjusting for age, BMI, energy, and eGFR, and stratifying by sex, logistic regression analysis showed that DAL level (OR = 6.47, 95% CI 1.19–35.18, p = 0.031) was a related factor for CKD and T2DM in females.ConclusionDAL score is a related factor for patients with T2DM and CKD.https://www.frontiersin.org/articles/10.3389/fnut.2025.1581009/fullchronic kidney diseasetype 2 diabetes mellitusdietary acid loadpotential renal acid loadnet endogenous acid |
| spellingShingle | Hui Huang Hui Huang Qian Wang Ruimin Zhang Ruimin Zhang Fang Liu Fang Liu Yue Niu Yayong Luo Shuang Li Tao Li Zhengchun Tang Zhengchun Tang Xiaolong Wang Jian Yang Yong Wang Li Zhang Sha Luo Weiguang Zhang Ying Zheng Weizhu Deng Guangyan Cai Xiangmei Chen Xiangmei Chen Xiangmei Chen Zheyi Dong Correlation between dietary acid–base load and chronic kidney disease patients with type 2 diabetes mellitus Frontiers in Nutrition chronic kidney disease type 2 diabetes mellitus dietary acid load potential renal acid load net endogenous acid |
| title | Correlation between dietary acid–base load and chronic kidney disease patients with type 2 diabetes mellitus |
| title_full | Correlation between dietary acid–base load and chronic kidney disease patients with type 2 diabetes mellitus |
| title_fullStr | Correlation between dietary acid–base load and chronic kidney disease patients with type 2 diabetes mellitus |
| title_full_unstemmed | Correlation between dietary acid–base load and chronic kidney disease patients with type 2 diabetes mellitus |
| title_short | Correlation between dietary acid–base load and chronic kidney disease patients with type 2 diabetes mellitus |
| title_sort | correlation between dietary acid base load and chronic kidney disease patients with type 2 diabetes mellitus |
| topic | chronic kidney disease type 2 diabetes mellitus dietary acid load potential renal acid load net endogenous acid |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1581009/full |
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