Prediction of primary biliary cholangitis among health check-up population with anti-mitochondrial M2 antibody positive
Background/Aims Anti-mitochondrial M2 antibody (AMA-M2) is a specific marker for primary biliary cholangitis (PBC) and it could be also present in non-PBC individuals. Methods A total of 72,173 Chinese health check-up individuals tested AMA-M2, of which non-PBC AMA-M2 positive individuals were perfo...
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Korean Association for the Study of the Liver
2025-04-01
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| Series: | Clinical and Molecular Hepatology |
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| Online Access: | http://e-cmh.org/upload/pdf/cmh-2024-0416.pdf |
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| author | Haolong Li Song Liu Xu Wang Xinxin Feng Siyu Wang Yanli Zhang Fengchun Zhang Li Wang Tengda Xu Yongzhe Li |
| author_facet | Haolong Li Song Liu Xu Wang Xinxin Feng Siyu Wang Yanli Zhang Fengchun Zhang Li Wang Tengda Xu Yongzhe Li |
| author_sort | Haolong Li |
| collection | DOAJ |
| description | Background/Aims Anti-mitochondrial M2 antibody (AMA-M2) is a specific marker for primary biliary cholangitis (PBC) and it could be also present in non-PBC individuals. Methods A total of 72,173 Chinese health check-up individuals tested AMA-M2, of which non-PBC AMA-M2 positive individuals were performed follow-up. Baseline data of both clinical characteristics and laboratory examinations were collected in all AMA-M2-positive individuals. Least absolute shrinkage and selection operator (LASSO) regression was performed to investigate the potential variables for developing PBC. Results A total of 2,333 individuals were positive with AMA-M2. Eighty-two individuals had a medical history of PBC or fulfilled the diagnostic criteria of PBC at baseline, and 2,076 individuals were non-PBC. After a median follow-up of 6.6 years, 0.6% developed PBC, with an accumulative 5-year incidence rate of 0.5%. LASSO regression showed that levels of alkaline phosphatase (ALP), gamma-glutamyl transpeptidase (GGT), immunoglobulin M (IgM), eosinophilia proportion (EOS%), gamma globulin percentage, and hemoglobin (HGB) were potential variables for developing PBC. Multivariate Cox regression is used to construct a predictive model based on 7 selected variables, and time-dependent receiver operating characteristic analysis showed that the area under the curve of the prediction model at 3, 5, and 10 years were, respectively, 1.000, 0.875, and 0.917. Conclusions This study offers insights into the onset of PBC among individuals who tested positive for AMA-M2 during routine health check-ups. The prediction model based on ALP, GGT, IgM, EOS%, gamma globulin percentage, HGB, and sex has a certain predictive ability for the occurrence of PBC in this population. |
| format | Article |
| id | doaj-art-2ee60b7d4dd6422fb4b25d8800441306 |
| institution | OA Journals |
| issn | 2287-2728 2287-285X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Korean Association for the Study of the Liver |
| record_format | Article |
| series | Clinical and Molecular Hepatology |
| spelling | doaj-art-2ee60b7d4dd6422fb4b25d88004413062025-08-20T02:13:19ZengKorean Association for the Study of the LiverClinical and Molecular Hepatology2287-27282287-285X2025-04-0131247448810.3350/cmh.2024.04162130Prediction of primary biliary cholangitis among health check-up population with anti-mitochondrial M2 antibody positiveHaolong Li0Song Liu1Xu Wang2Xinxin Feng3Siyu Wang4Yanli Zhang5Fengchun Zhang6Li Wang7Tengda Xu8Yongzhe Li9 Department of Clinical Laboratory, State key Laboratory of Complex, Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China Center for Bioinformatics, National Infrastructures for Translational Medicine, Institute of Clinical Medicine & Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Department of Rheumatology, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China Department of Clinical Laboratory, State key Laboratory of Complex, Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China Department of Clinical Laboratory, State key Laboratory of Complex, Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China Department of Health Management, Peking Union Medical College Hospital, Beijing, China Department of Rheumatology, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China Department of Rheumatology, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China Department of Health Management, Peking Union Medical College Hospital, Beijing, China Department of Clinical Laboratory, State key Laboratory of Complex, Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, ChinaBackground/Aims Anti-mitochondrial M2 antibody (AMA-M2) is a specific marker for primary biliary cholangitis (PBC) and it could be also present in non-PBC individuals. Methods A total of 72,173 Chinese health check-up individuals tested AMA-M2, of which non-PBC AMA-M2 positive individuals were performed follow-up. Baseline data of both clinical characteristics and laboratory examinations were collected in all AMA-M2-positive individuals. Least absolute shrinkage and selection operator (LASSO) regression was performed to investigate the potential variables for developing PBC. Results A total of 2,333 individuals were positive with AMA-M2. Eighty-two individuals had a medical history of PBC or fulfilled the diagnostic criteria of PBC at baseline, and 2,076 individuals were non-PBC. After a median follow-up of 6.6 years, 0.6% developed PBC, with an accumulative 5-year incidence rate of 0.5%. LASSO regression showed that levels of alkaline phosphatase (ALP), gamma-glutamyl transpeptidase (GGT), immunoglobulin M (IgM), eosinophilia proportion (EOS%), gamma globulin percentage, and hemoglobin (HGB) were potential variables for developing PBC. Multivariate Cox regression is used to construct a predictive model based on 7 selected variables, and time-dependent receiver operating characteristic analysis showed that the area under the curve of the prediction model at 3, 5, and 10 years were, respectively, 1.000, 0.875, and 0.917. Conclusions This study offers insights into the onset of PBC among individuals who tested positive for AMA-M2 during routine health check-ups. The prediction model based on ALP, GGT, IgM, EOS%, gamma globulin percentage, HGB, and sex has a certain predictive ability for the occurrence of PBC in this population.http://e-cmh.org/upload/pdf/cmh-2024-0416.pdfprimary biliary cholangitisanti-mitochondrial m2 antibodyhealth check-up |
| spellingShingle | Haolong Li Song Liu Xu Wang Xinxin Feng Siyu Wang Yanli Zhang Fengchun Zhang Li Wang Tengda Xu Yongzhe Li Prediction of primary biliary cholangitis among health check-up population with anti-mitochondrial M2 antibody positive Clinical and Molecular Hepatology primary biliary cholangitis anti-mitochondrial m2 antibody health check-up |
| title | Prediction of primary biliary cholangitis among health check-up population with anti-mitochondrial M2 antibody positive |
| title_full | Prediction of primary biliary cholangitis among health check-up population with anti-mitochondrial M2 antibody positive |
| title_fullStr | Prediction of primary biliary cholangitis among health check-up population with anti-mitochondrial M2 antibody positive |
| title_full_unstemmed | Prediction of primary biliary cholangitis among health check-up population with anti-mitochondrial M2 antibody positive |
| title_short | Prediction of primary biliary cholangitis among health check-up population with anti-mitochondrial M2 antibody positive |
| title_sort | prediction of primary biliary cholangitis among health check up population with anti mitochondrial m2 antibody positive |
| topic | primary biliary cholangitis anti-mitochondrial m2 antibody health check-up |
| url | http://e-cmh.org/upload/pdf/cmh-2024-0416.pdf |
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