Long-Term Safety and Efficacy of Repeated Cycles of RimabotulinumtoxinB in the Treatment of Chronic Sialorrhea: Results of the OPTIMYST Trial

Long-Term Safety and Efficacy of Repeated Cycles of RimabotulinumtoxinB in the Treatment of Chronic Sialorrhea: Results of the OPTIMYST Trial

Abstract Introduction Botulinum toxin injections into the salivary glands inhibit saliva production by reducing the release of acetylcholine at the parasympathetic nerve terminals within the salivary gland. The phase 3 study reported here assessed the safety, tolerability, and effectiveness of repea...

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Main Authors: Rajesh Pahwa, Eric Molho, Mark Lew, Khashayar Dashtipour, Ramon A. Gil, Fredy J. Revilla, Thomas Clinch, Peibing Qin, Stuart H. Isaacson, on behalf of the OPen Label Trial of Intraglandular MYobloc injections for Sialorrhea Treatment (OPTIMYST) study group
Format: Article
Language:English
Published: Adis, Springer Healthcare 2025-06-01
Series:Neurology and Therapy
Subjects:
Botulinum toxin type B
Sialorrhea
Drooling
RimabotulinumtoxinB
Parkinson’s disease
Amyotrophic lateral sclerosis
Online Access:https://doi.org/10.1007/s40120-025-00777-z
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