Targeting osteosarcopenia and multimorbidity for frailty prevention through identification and deep phenotyping methods in healthy ageing and high-burden disease cohorts (OPTIMA-C): a longitudinal observational cohort study protocol for neuromusculoskeletal muscle health

Targeting osteosarcopenia and multimorbidity for frailty prevention through identification and deep phenotyping methods in healthy ageing and high-burden disease cohorts (OPTIMA-C): a longitudinal observational cohort study protocol for neuromusculoskeletal muscle health

Introduction Sarcopenia and frailty have been identified as negative predictors of health outcomes. Patients with stroke, traumatic brain injury (TBI), knee osteoarthritis (OA) and breast cancer commonly experience low physical activity levels in the chronic phase of recovery. This prospective study...

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Main Authors: Keng He Kong, Eng Sing Lee, Wee Shiong Lim, Sai Zhen Sim, Bryan Yijia Tan, Matthew Rong Jie Tay, Jong Moon Kim, Poo Lee Ong, Lay Wai Khin, Chin Jung Wong, Michael Gui Jie Yam, Justin Linghui Chew, Alvin Wai Kit Tan, Ananda Sidarta, Emily Yee, Karen Sui Geok Chua
Format: Article
Language:English
Published: BMJ Publishing Group 2025-05-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/15/5/e094279.full
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