Emerging magic bullet: subcellular organelle-targeted cancer therapy
The therapeutic efficacy of anticancer drugs heavily relies on their concentration and retention at the corresponding target site. Hence, merely increasing the cellular concentration of drugs is insufficient to achieve satisfactory therapeutic outcomes, especially for the drugs that target specific...
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| Format: | Article |
| Language: | English |
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De Gruyter
2025-04-01
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| Series: | Medical Review |
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| Online Access: | https://doi.org/10.1515/mr-2024-0044 |
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| author | Yan Yue Zhang Yimeng Liu Jianxiong Chen Binlong Wang Yiguang |
| author_facet | Yan Yue Zhang Yimeng Liu Jianxiong Chen Binlong Wang Yiguang |
| author_sort | Yan Yue |
| collection | DOAJ |
| description | The therapeutic efficacy of anticancer drugs heavily relies on their concentration and retention at the corresponding target site. Hence, merely increasing the cellular concentration of drugs is insufficient to achieve satisfactory therapeutic outcomes, especially for the drugs that target specific intracellular sites. This necessitates the implementation of more precise targeting strategies to overcome the limitations posed by diffusion distribution and nonspecific interactions within cells. Consequently, subcellular organelle-targeted cancer therapy, characterized by its exceptional precision, have emerged as a promising approach to eradicate cancer cells through the specific disruption of subcellular organelles. Owing to several advantages including minimized dosage and side effect, optimized efficacy, and reversal of multidrug resistance, subcellular organelle-targeted therapies have garnered significant research interest in recent years. In this review, we comprehensively summarize the distribution of drug targets, targeted delivery strategies at various levels, and sophisticated strategies for targeting specific subcellular organelles. Additionally, we highlight the significance of subcellular targeting in cancer therapy and present essential considerations for its clinical translation. |
| format | Article |
| id | doaj-art-2edfa7f32cfb4900bf3d9546f7ee77b7 |
| institution | OA Journals |
| issn | 2749-9642 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Medical Review |
| spelling | doaj-art-2edfa7f32cfb4900bf3d9546f7ee77b72025-08-20T02:11:55ZengDe GruyterMedical Review2749-96422025-04-015211713810.1515/mr-2024-0044Emerging magic bullet: subcellular organelle-targeted cancer therapyYan Yue0Zhang Yimeng1Liu Jianxiong2Chen Binlong3Wang Yiguang4Department of Central Laboratory, Peking University First Hospital, Beijing, ChinaState Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, ChinaState Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, ChinaDepartment of Central Laboratory, Peking University First Hospital, Beijing, ChinaState Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, ChinaThe therapeutic efficacy of anticancer drugs heavily relies on their concentration and retention at the corresponding target site. Hence, merely increasing the cellular concentration of drugs is insufficient to achieve satisfactory therapeutic outcomes, especially for the drugs that target specific intracellular sites. This necessitates the implementation of more precise targeting strategies to overcome the limitations posed by diffusion distribution and nonspecific interactions within cells. Consequently, subcellular organelle-targeted cancer therapy, characterized by its exceptional precision, have emerged as a promising approach to eradicate cancer cells through the specific disruption of subcellular organelles. Owing to several advantages including minimized dosage and side effect, optimized efficacy, and reversal of multidrug resistance, subcellular organelle-targeted therapies have garnered significant research interest in recent years. In this review, we comprehensively summarize the distribution of drug targets, targeted delivery strategies at various levels, and sophisticated strategies for targeting specific subcellular organelles. Additionally, we highlight the significance of subcellular targeting in cancer therapy and present essential considerations for its clinical translation.https://doi.org/10.1515/mr-2024-0044cancerdrug targetssubcellular targetingdrug deliveryorganelle |
| spellingShingle | Yan Yue Zhang Yimeng Liu Jianxiong Chen Binlong Wang Yiguang Emerging magic bullet: subcellular organelle-targeted cancer therapy Medical Review cancer drug targets subcellular targeting drug delivery organelle |
| title | Emerging magic bullet: subcellular organelle-targeted cancer therapy |
| title_full | Emerging magic bullet: subcellular organelle-targeted cancer therapy |
| title_fullStr | Emerging magic bullet: subcellular organelle-targeted cancer therapy |
| title_full_unstemmed | Emerging magic bullet: subcellular organelle-targeted cancer therapy |
| title_short | Emerging magic bullet: subcellular organelle-targeted cancer therapy |
| title_sort | emerging magic bullet subcellular organelle targeted cancer therapy |
| topic | cancer drug targets subcellular targeting drug delivery organelle |
| url | https://doi.org/10.1515/mr-2024-0044 |
| work_keys_str_mv | AT yanyue emergingmagicbulletsubcellularorganelletargetedcancertherapy AT zhangyimeng emergingmagicbulletsubcellularorganelletargetedcancertherapy AT liujianxiong emergingmagicbulletsubcellularorganelletargetedcancertherapy AT chenbinlong emergingmagicbulletsubcellularorganelletargetedcancertherapy AT wangyiguang emergingmagicbulletsubcellularorganelletargetedcancertherapy |