Gut Microbiota and Alzheimer Disease
The hallmarks of Alzheimer’s disease (AD) include brain dysfunction and the buildup of amyloid and tau proteins. The onset of dementia is one of the latter symptoms. Imaging diagnostics allowed for the detection of amyloid buildup in the brain 10–20 years before the emergence of overt signs of the d...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | Acta Neurologica Taiwanica |
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| Online Access: | https://journals.lww.com/10.4103/ANT.ANT_113_0046 |
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| author | Lester Raymundo Dominguez Huarcaya |
| author_facet | Lester Raymundo Dominguez Huarcaya |
| author_sort | Lester Raymundo Dominguez Huarcaya |
| collection | DOAJ |
| description | The hallmarks of Alzheimer’s disease (AD) include brain dysfunction and the buildup of amyloid and tau proteins. The onset of dementia is one of the latter symptoms. Imaging diagnostics allowed for the detection of amyloid buildup in the brain 10–20 years before the emergence of overt signs of the disease. The application of imaging diagnostic techniques allowed for this identification. Within the next few decades, the incidence and frequency of this disease are expected to reach epidemic proportions unless measures are done to stop or slow its growth. However, unless action is taken to slow or stop the disease’s progression, it will continue to threaten the health of the general public. Recently, there has been some speculation that the gut flora might contribute to the development of AD. Not only that, but the rapidly expanding ischemia etiology is another possible contributor to the issue. Rumor has it that there’s a network connecting the brain and the stomach called the “gut-brain-microbiota axis.” The hypothesis is based on this network. Furthermore, a large amount of evidence implies that the gut microbiota (GMB) could potentially contribute to the onset of AD. It has been suggested that the GMB could play a role in the onset of AD. This notion has been bolstered by new studies. It is quite probable that this review will address the prospect of a link between the microbiome and AD. This concept could be explored as a potential therapy or preventative measure. Some techniques that show promise as new treatments for AD include changes to the GMB, which can be achieved through dietary changes or positive microflora interventions, and changes to microbiological partners and their products, like amyloid protein. |
| format | Article |
| id | doaj-art-2ed9ae6222a34abc9df79acbb44f6c9c |
| institution | Kabale University |
| issn | 1028-768X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Acta Neurologica Taiwanica |
| spelling | doaj-art-2ed9ae6222a34abc9df79acbb44f6c9c2025-08-20T03:25:59ZengWolters Kluwer Medknow PublicationsActa Neurologica Taiwanica1028-768X2025-01-0134111210.4103/ANT.ANT_113_0046Gut Microbiota and Alzheimer DiseaseLester Raymundo Dominguez HuarcayaThe hallmarks of Alzheimer’s disease (AD) include brain dysfunction and the buildup of amyloid and tau proteins. The onset of dementia is one of the latter symptoms. Imaging diagnostics allowed for the detection of amyloid buildup in the brain 10–20 years before the emergence of overt signs of the disease. The application of imaging diagnostic techniques allowed for this identification. Within the next few decades, the incidence and frequency of this disease are expected to reach epidemic proportions unless measures are done to stop or slow its growth. However, unless action is taken to slow or stop the disease’s progression, it will continue to threaten the health of the general public. Recently, there has been some speculation that the gut flora might contribute to the development of AD. Not only that, but the rapidly expanding ischemia etiology is another possible contributor to the issue. Rumor has it that there’s a network connecting the brain and the stomach called the “gut-brain-microbiota axis.” The hypothesis is based on this network. Furthermore, a large amount of evidence implies that the gut microbiota (GMB) could potentially contribute to the onset of AD. It has been suggested that the GMB could play a role in the onset of AD. This notion has been bolstered by new studies. It is quite probable that this review will address the prospect of a link between the microbiome and AD. This concept could be explored as a potential therapy or preventative measure. Some techniques that show promise as new treatments for AD include changes to the GMB, which can be achieved through dietary changes or positive microflora interventions, and changes to microbiological partners and their products, like amyloid protein.https://journals.lww.com/10.4103/ANT.ANT_113_0046alzheimer’s diseasegut dysbiosisgut microbiotamicrobiota-gut-brain axisneuroinflammation |
| spellingShingle | Lester Raymundo Dominguez Huarcaya Gut Microbiota and Alzheimer Disease Acta Neurologica Taiwanica alzheimer’s disease gut dysbiosis gut microbiota microbiota-gut-brain axis neuroinflammation |
| title | Gut Microbiota and Alzheimer Disease |
| title_full | Gut Microbiota and Alzheimer Disease |
| title_fullStr | Gut Microbiota and Alzheimer Disease |
| title_full_unstemmed | Gut Microbiota and Alzheimer Disease |
| title_short | Gut Microbiota and Alzheimer Disease |
| title_sort | gut microbiota and alzheimer disease |
| topic | alzheimer’s disease gut dysbiosis gut microbiota microbiota-gut-brain axis neuroinflammation |
| url | https://journals.lww.com/10.4103/ANT.ANT_113_0046 |
| work_keys_str_mv | AT lesterraymundodominguezhuarcaya gutmicrobiotaandalzheimerdisease |