The effect of bariatric surgery on anthropometric indices, gut microbiome, and microbial metabolites in patients with NAFLD: a systematic review
Abstract Obesity is a global health challenge linked with NAFLD (nonalcoholic fatty liver disease). Bariatric surgery can induce NAFLD remission by altering gut microbiota. This study evaluates bariatric surgery’s effects on anthropometric indices, gut microbiota, and microbial metabolites in NAFLD...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2025-06-01
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| Series: | Egyptian Liver Journal |
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| Online Access: | https://doi.org/10.1186/s43066-025-00425-z |
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| author | Aylin Hajizadeh Hanieh-Sadat Ejtahed Mohammad Reza Fadaeifard Fateme Ziamanesh Shirin Hasani-Ranjbar Mahboobeh Hemmatabadi Nooshin Shirzad |
| author_facet | Aylin Hajizadeh Hanieh-Sadat Ejtahed Mohammad Reza Fadaeifard Fateme Ziamanesh Shirin Hasani-Ranjbar Mahboobeh Hemmatabadi Nooshin Shirzad |
| author_sort | Aylin Hajizadeh |
| collection | DOAJ |
| description | Abstract Obesity is a global health challenge linked with NAFLD (nonalcoholic fatty liver disease). Bariatric surgery can induce NAFLD remission by altering gut microbiota. This study evaluates bariatric surgery’s effects on anthropometric indices, gut microbiota, and microbial metabolites in NAFLD patients. Data from major databases up to October 2023 were analyzed. Studies were assessed for quality using the Newcastle–Ottawa scale (NOS). Eleven studies were reviewed. Bariatric surgery increased Bacteroides, Akkermansia, and “Proteobacteria” and decreased “Actinomycetota.” It also altered bile acid profiles, reducing primary conjugated bile acids and increasing secondary conjugated bile acids, particularly glycoursodeoxycholic acid (GUDCA). Improvements in body mass index were observed in NAFLD patient’s post-surgery. Bariatric surgery impacts gut microbiota and bile acid profiles, playing a potential role in NAFLD remission. Further extensive studies are required due to study inconsistencies. |
| format | Article |
| id | doaj-art-2ed6033efe5349838ceec6dfe5cd7935 |
| institution | OA Journals |
| issn | 2090-6226 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Egyptian Liver Journal |
| spelling | doaj-art-2ed6033efe5349838ceec6dfe5cd79352025-08-20T02:30:44ZengSpringerOpenEgyptian Liver Journal2090-62262025-06-0115111110.1186/s43066-025-00425-zThe effect of bariatric surgery on anthropometric indices, gut microbiome, and microbial metabolites in patients with NAFLD: a systematic reviewAylin Hajizadeh0Hanieh-Sadat Ejtahed1Mohammad Reza Fadaeifard2Fateme Ziamanesh3Shirin Hasani-Ranjbar4Mahboobeh Hemmatabadi5Nooshin Shirzad6Obesity and Eating Habits Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical SciencesObesity and Eating Habits Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical SciencesSchool of Medicine, Tehran University of Medical SciencesEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical SciencesObesity and Eating Habits Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical SciencesEndocrine Research Center, Valiasr Hospital, Imam Khomeini Hospital Complex, Tehran University of Medical SciencesEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical SciencesAbstract Obesity is a global health challenge linked with NAFLD (nonalcoholic fatty liver disease). Bariatric surgery can induce NAFLD remission by altering gut microbiota. This study evaluates bariatric surgery’s effects on anthropometric indices, gut microbiota, and microbial metabolites in NAFLD patients. Data from major databases up to October 2023 were analyzed. Studies were assessed for quality using the Newcastle–Ottawa scale (NOS). Eleven studies were reviewed. Bariatric surgery increased Bacteroides, Akkermansia, and “Proteobacteria” and decreased “Actinomycetota.” It also altered bile acid profiles, reducing primary conjugated bile acids and increasing secondary conjugated bile acids, particularly glycoursodeoxycholic acid (GUDCA). Improvements in body mass index were observed in NAFLD patient’s post-surgery. Bariatric surgery impacts gut microbiota and bile acid profiles, playing a potential role in NAFLD remission. Further extensive studies are required due to study inconsistencies.https://doi.org/10.1186/s43066-025-00425-zMicrobiomeMicrobial metabolitesBariatric surgeryAnthropometric indicesNAFLD |
| spellingShingle | Aylin Hajizadeh Hanieh-Sadat Ejtahed Mohammad Reza Fadaeifard Fateme Ziamanesh Shirin Hasani-Ranjbar Mahboobeh Hemmatabadi Nooshin Shirzad The effect of bariatric surgery on anthropometric indices, gut microbiome, and microbial metabolites in patients with NAFLD: a systematic review Egyptian Liver Journal Microbiome Microbial metabolites Bariatric surgery Anthropometric indices NAFLD |
| title | The effect of bariatric surgery on anthropometric indices, gut microbiome, and microbial metabolites in patients with NAFLD: a systematic review |
| title_full | The effect of bariatric surgery on anthropometric indices, gut microbiome, and microbial metabolites in patients with NAFLD: a systematic review |
| title_fullStr | The effect of bariatric surgery on anthropometric indices, gut microbiome, and microbial metabolites in patients with NAFLD: a systematic review |
| title_full_unstemmed | The effect of bariatric surgery on anthropometric indices, gut microbiome, and microbial metabolites in patients with NAFLD: a systematic review |
| title_short | The effect of bariatric surgery on anthropometric indices, gut microbiome, and microbial metabolites in patients with NAFLD: a systematic review |
| title_sort | effect of bariatric surgery on anthropometric indices gut microbiome and microbial metabolites in patients with nafld a systematic review |
| topic | Microbiome Microbial metabolites Bariatric surgery Anthropometric indices NAFLD |
| url | https://doi.org/10.1186/s43066-025-00425-z |
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