Serum Neuropeptide Y Levels Are Associated with TNF-α Levels and Disease Activity in Rheumatoid Arthritis

Background. Neuropeptide Y (NPY) is a sympathetic neurotransmitter with effects on the regulation of inflammatory cells. The role of NPY on autoimmune inflammatory diseases such as rheumatoid arthritis (RA) is not completely understood. Therefore, we evaluate if NPY levels are markers of disease act...

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Main Authors: Melissa Ramirez-Villafaña, Ana M. Saldaña-Cruz, Javier A. Aceves-Aceves, Edsaul E. Perez-Guerrero, Nicté S. Fajardo-Robledo, Edy D. Rubio-Arellano, Cesar A. Nava-Valdivia, Maria O. Carrillo-Escalante, Sylvia E. Totsuka-Sutto, David Cardona-Müller, Betsabe Contreras-Haro, Mario Salazar-Paramo, Ernesto G. Cardona-Muñoz, M. Huerta, Jorge I. Gamez-Nava, Norma A. Rodriguez-Jimenez, Laura Gonzalez-Lopez
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Journal of Immunology Research
Online Access:http://dx.doi.org/10.1155/2020/8982163
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author Melissa Ramirez-Villafaña
Ana M. Saldaña-Cruz
Javier A. Aceves-Aceves
Edsaul E. Perez-Guerrero
Nicté S. Fajardo-Robledo
Edy D. Rubio-Arellano
Cesar A. Nava-Valdivia
Maria O. Carrillo-Escalante
Sylvia E. Totsuka-Sutto
David Cardona-Müller
Betsabe Contreras-Haro
Mario Salazar-Paramo
Ernesto G. Cardona-Muñoz
M. Huerta
Jorge I. Gamez-Nava
Norma A. Rodriguez-Jimenez
Laura Gonzalez-Lopez
author_facet Melissa Ramirez-Villafaña
Ana M. Saldaña-Cruz
Javier A. Aceves-Aceves
Edsaul E. Perez-Guerrero
Nicté S. Fajardo-Robledo
Edy D. Rubio-Arellano
Cesar A. Nava-Valdivia
Maria O. Carrillo-Escalante
Sylvia E. Totsuka-Sutto
David Cardona-Müller
Betsabe Contreras-Haro
Mario Salazar-Paramo
Ernesto G. Cardona-Muñoz
M. Huerta
Jorge I. Gamez-Nava
Norma A. Rodriguez-Jimenez
Laura Gonzalez-Lopez
author_sort Melissa Ramirez-Villafaña
collection DOAJ
description Background. Neuropeptide Y (NPY) is a sympathetic neurotransmitter with effects on the regulation of inflammatory cells. The role of NPY on autoimmune inflammatory diseases such as rheumatoid arthritis (RA) is not completely understood. Therefore, we evaluate if NPY levels are markers of disease activity in RA and if there is a correlation between NPY levels and tumor necrosis factor-alpha (TNF-α), leptin, and interleukin 6 (IL-6) levels. Methods. Cross-sectional design, including 108 women with RA. We assessed disease activity by DAS28-ESR (considering active disease a score of ≥2.6). Serum NPY levels and anti-CCP2 antibody, TNF-α, IL-6, and leptin levels were quantified (ELISA). Results. Sixty-eight RA had an active disease (RA-active), and 40 were in remission (RA-remission). RA-active patients had higher NPY levels vs. RA-remission (22.8±13.6 vs. 17.8±10.3; p=0.04). NPY levels correlated with increased TNF-α levels (r=0.32, p=0.001). Leptin or IL-6 did not correlate with NPY levels. In the logistic regression analysis, NPY increased the risk of disease activity (OR: 1.04, 95% CI 1.006-1.09, and p=0.03). Conclusion. Higher NPY levels are an independent marker of disease activity in RA. This study encourages the quantification of NPY levels as a surrogate marker for RA-active. Future studies evaluating the role of NPY levels interacting with other proinflammatory cytokines are required.
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spelling doaj-art-2ed3a03221eb4ff781cc6938608d97962025-02-03T01:04:38ZengWileyJournal of Immunology Research2314-88612314-71562020-01-01202010.1155/2020/89821638982163Serum Neuropeptide Y Levels Are Associated with TNF-α Levels and Disease Activity in Rheumatoid ArthritisMelissa Ramirez-Villafaña0Ana M. Saldaña-Cruz1Javier A. Aceves-Aceves2Edsaul E. Perez-Guerrero3Nicté S. Fajardo-Robledo4Edy D. Rubio-Arellano5Cesar A. Nava-Valdivia6Maria O. Carrillo-Escalante7Sylvia E. Totsuka-Sutto8David Cardona-Müller9Betsabe Contreras-Haro10Mario Salazar-Paramo11Ernesto G. Cardona-Muñoz12M. Huerta13Jorge I. Gamez-Nava14Norma A. Rodriguez-Jimenez15Laura Gonzalez-Lopez16Programa de Doctorado en Ciencias Médicas, Universidad de Colima, 28040 Colima, Colima, MexicoInstituto de Terapeutica Experimental y Clínica, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdeG), 44340 Guadalajara, Jalisco, MexicoPrograma de Doctorado en Farmacología, CUCS, Universidad de Guadalajara, 44340 Guadalajara, Jalisco, MexicoInstituto de Investigación en Ciencias Biomédicas, CUCS, UdeG, 44340 Guadalajara, Jalisco, MexicoLaboratorio de Investigación y Desarrollo Farmacéutico, Centro Universitario de Ciencias Exactas e Ingenierías, Universidad de Guadalajara, 44430 Guadalajara, Jalisco, MexicoInstituto de Terapeutica Experimental y Clínica, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdeG), 44340 Guadalajara, Jalisco, MexicoDepartamento de Microbiología y Patología, CUCS, Universidad de Guadalajara, 44340 Guadalajara, Jalisco, MexicoUnidad de Investigación Biomédica 02, Hospital de Especialidades, Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), 44340 Guadalajara, Jalisco, MexicoDepartamento de Fisiología, CUCS, Universidad de Guadalajara, 44340 Guadalajara, Jalisco, MexicoDepartamento de Fisiología, CUCS, Universidad de Guadalajara, 44340 Guadalajara, Jalisco, MexicoDepartamento de Ciencias Biomédicas, Centro Universitario de Tonalá, Universidad de Guadalajara, 45425 Tonalá, Jalisco, MexicoUnidad de Investigación Biomédica 02, Hospital de Especialidades, Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), 44340 Guadalajara, Jalisco, MexicoDepartamento de Fisiología, CUCS, Universidad de Guadalajara, 44340 Guadalajara, Jalisco, MexicoCentro Universitario de Investigaciones Biomédicas, Universidad de Colima, 28040 Colima, Colima, MexicoUnidad de Investigación Biomédica 02, Hospital de Especialidades, Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), 44340 Guadalajara, Jalisco, MexicoInstituto de Terapeutica Experimental y Clínica, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdeG), 44340 Guadalajara, Jalisco, MexicoPrograma de Doctorado en Farmacología, CUCS, Universidad de Guadalajara, 44340 Guadalajara, Jalisco, MexicoBackground. Neuropeptide Y (NPY) is a sympathetic neurotransmitter with effects on the regulation of inflammatory cells. The role of NPY on autoimmune inflammatory diseases such as rheumatoid arthritis (RA) is not completely understood. Therefore, we evaluate if NPY levels are markers of disease activity in RA and if there is a correlation between NPY levels and tumor necrosis factor-alpha (TNF-α), leptin, and interleukin 6 (IL-6) levels. Methods. Cross-sectional design, including 108 women with RA. We assessed disease activity by DAS28-ESR (considering active disease a score of ≥2.6). Serum NPY levels and anti-CCP2 antibody, TNF-α, IL-6, and leptin levels were quantified (ELISA). Results. Sixty-eight RA had an active disease (RA-active), and 40 were in remission (RA-remission). RA-active patients had higher NPY levels vs. RA-remission (22.8±13.6 vs. 17.8±10.3; p=0.04). NPY levels correlated with increased TNF-α levels (r=0.32, p=0.001). Leptin or IL-6 did not correlate with NPY levels. In the logistic regression analysis, NPY increased the risk of disease activity (OR: 1.04, 95% CI 1.006-1.09, and p=0.03). Conclusion. Higher NPY levels are an independent marker of disease activity in RA. This study encourages the quantification of NPY levels as a surrogate marker for RA-active. Future studies evaluating the role of NPY levels interacting with other proinflammatory cytokines are required.http://dx.doi.org/10.1155/2020/8982163
spellingShingle Melissa Ramirez-Villafaña
Ana M. Saldaña-Cruz
Javier A. Aceves-Aceves
Edsaul E. Perez-Guerrero
Nicté S. Fajardo-Robledo
Edy D. Rubio-Arellano
Cesar A. Nava-Valdivia
Maria O. Carrillo-Escalante
Sylvia E. Totsuka-Sutto
David Cardona-Müller
Betsabe Contreras-Haro
Mario Salazar-Paramo
Ernesto G. Cardona-Muñoz
M. Huerta
Jorge I. Gamez-Nava
Norma A. Rodriguez-Jimenez
Laura Gonzalez-Lopez
Serum Neuropeptide Y Levels Are Associated with TNF-α Levels and Disease Activity in Rheumatoid Arthritis
Journal of Immunology Research
title Serum Neuropeptide Y Levels Are Associated with TNF-α Levels and Disease Activity in Rheumatoid Arthritis
title_full Serum Neuropeptide Y Levels Are Associated with TNF-α Levels and Disease Activity in Rheumatoid Arthritis
title_fullStr Serum Neuropeptide Y Levels Are Associated with TNF-α Levels and Disease Activity in Rheumatoid Arthritis
title_full_unstemmed Serum Neuropeptide Y Levels Are Associated with TNF-α Levels and Disease Activity in Rheumatoid Arthritis
title_short Serum Neuropeptide Y Levels Are Associated with TNF-α Levels and Disease Activity in Rheumatoid Arthritis
title_sort serum neuropeptide y levels are associated with tnf α levels and disease activity in rheumatoid arthritis
url http://dx.doi.org/10.1155/2020/8982163
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