The beneficial effects of curcumin on aging and age-related diseases: from oxidative stress to antioxidant mechanisms, brain health and apoptosis
Aging and age-related disease are among the most common and challenging issues worldwide. During the aging process, the accumulation of oxidative stress, DNA damage, telomere dysfunction, and other related changes lead to cellular dysfunction and the development of diseases such as neurodegenerative...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1533963/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832593916461842432 |
|---|---|
| author | Ying He Ying He Yongqing Liu Min Zhang |
| author_facet | Ying He Ying He Yongqing Liu Min Zhang |
| author_sort | Ying He |
| collection | DOAJ |
| description | Aging and age-related disease are among the most common and challenging issues worldwide. During the aging process, the accumulation of oxidative stress, DNA damage, telomere dysfunction, and other related changes lead to cellular dysfunction and the development of diseases such as neurodegenerative and cardiovascular conditions. Curcumin is a widely-used dietary supplement against various diseases such as cancer, diabetes, cardiovascular diseases and aging. This agent mediates its effects through several mechanisms, including the reduction of reactive oxygen species (ROS) and oxidative stress-induced damage, as well as the modulation of subcellular signaling pathways such as AMPK, AKT/mTOR, and NF-κB. These pathways are involved in cellular senescence and inflammation, and their modulation can improve cell function and help prevent disease. In cancer, Curcumin can induce apoptosis in a variety of different tumor cell lines. Curcumin also activates redox reactions within cells inducing ROS production that leads to the upregulation of apoptosis receptors on the tumor cell membrane. Curcumin can also upregulate the expression and activity of p53 that inhibits tumor cell proliferation and increases apoptosis. Furthermore, curcumin has a potent inhibitory effect on the activity of nuclear factor kappa B (NF-κB) and cyclooxygenase-2 (COX-2), which are involved in the overexpression of antiapoptosis genes such as Bcl-2. It can also attenuate the regulation of antiapoptosis phosphoinositide 3-kinases (PI3K) signaling and increase the expression of mitogen-activated protein kinases (MAPKs) to induce endogenous production of ROS. Therefore, herein, we aim to summarize how curcumin affect different epigenetic processes (such as apoptosis and oxidative stress) in order to change aging-related mechanisms. Furthermore, we discuss its roles in age-related diseases, such as Alzheimer, Parkinson, osteoporosis, and cardiovascular diseases. |
| format | Article |
| id | doaj-art-2ed2b58487834d538ca412f4e2bd52aa |
| institution | Kabale University |
| issn | 1663-4365 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj-art-2ed2b58487834d538ca412f4e2bd52aa2025-01-20T07:20:09ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652025-01-011710.3389/fnagi.2025.15339631533963The beneficial effects of curcumin on aging and age-related diseases: from oxidative stress to antioxidant mechanisms, brain health and apoptosisYing He0Ying He1Yongqing Liu2Min Zhang3Department of Biological and Food Engineering, Lyuliang University, Lishi, Shanxi, ChinaCollege of Veterinary Medicine, Shanxi Agricultural University, Taigu, Shanxi, ChinaDepartment of Biological and Food Engineering, Lyuliang University, Lishi, Shanxi, ChinaKey Laboratory of Agro-Products Primary Processing, Academy of Agricultural Planning and Engineering, MARA, Beijing, ChinaAging and age-related disease are among the most common and challenging issues worldwide. During the aging process, the accumulation of oxidative stress, DNA damage, telomere dysfunction, and other related changes lead to cellular dysfunction and the development of diseases such as neurodegenerative and cardiovascular conditions. Curcumin is a widely-used dietary supplement against various diseases such as cancer, diabetes, cardiovascular diseases and aging. This agent mediates its effects through several mechanisms, including the reduction of reactive oxygen species (ROS) and oxidative stress-induced damage, as well as the modulation of subcellular signaling pathways such as AMPK, AKT/mTOR, and NF-κB. These pathways are involved in cellular senescence and inflammation, and their modulation can improve cell function and help prevent disease. In cancer, Curcumin can induce apoptosis in a variety of different tumor cell lines. Curcumin also activates redox reactions within cells inducing ROS production that leads to the upregulation of apoptosis receptors on the tumor cell membrane. Curcumin can also upregulate the expression and activity of p53 that inhibits tumor cell proliferation and increases apoptosis. Furthermore, curcumin has a potent inhibitory effect on the activity of nuclear factor kappa B (NF-κB) and cyclooxygenase-2 (COX-2), which are involved in the overexpression of antiapoptosis genes such as Bcl-2. It can also attenuate the regulation of antiapoptosis phosphoinositide 3-kinases (PI3K) signaling and increase the expression of mitogen-activated protein kinases (MAPKs) to induce endogenous production of ROS. Therefore, herein, we aim to summarize how curcumin affect different epigenetic processes (such as apoptosis and oxidative stress) in order to change aging-related mechanisms. Furthermore, we discuss its roles in age-related diseases, such as Alzheimer, Parkinson, osteoporosis, and cardiovascular diseases.https://www.frontiersin.org/articles/10.3389/fnagi.2025.1533963/fullagingage-related diseasescurcuminsignaling pathwaysnano-curcumin |
| spellingShingle | Ying He Ying He Yongqing Liu Min Zhang The beneficial effects of curcumin on aging and age-related diseases: from oxidative stress to antioxidant mechanisms, brain health and apoptosis Frontiers in Aging Neuroscience aging age-related diseases curcumin signaling pathways nano-curcumin |
| title | The beneficial effects of curcumin on aging and age-related diseases: from oxidative stress to antioxidant mechanisms, brain health and apoptosis |
| title_full | The beneficial effects of curcumin on aging and age-related diseases: from oxidative stress to antioxidant mechanisms, brain health and apoptosis |
| title_fullStr | The beneficial effects of curcumin on aging and age-related diseases: from oxidative stress to antioxidant mechanisms, brain health and apoptosis |
| title_full_unstemmed | The beneficial effects of curcumin on aging and age-related diseases: from oxidative stress to antioxidant mechanisms, brain health and apoptosis |
| title_short | The beneficial effects of curcumin on aging and age-related diseases: from oxidative stress to antioxidant mechanisms, brain health and apoptosis |
| title_sort | beneficial effects of curcumin on aging and age related diseases from oxidative stress to antioxidant mechanisms brain health and apoptosis |
| topic | aging age-related diseases curcumin signaling pathways nano-curcumin |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1533963/full |
| work_keys_str_mv | AT yinghe thebeneficialeffectsofcurcuminonagingandagerelateddiseasesfromoxidativestresstoantioxidantmechanismsbrainhealthandapoptosis AT yinghe thebeneficialeffectsofcurcuminonagingandagerelateddiseasesfromoxidativestresstoantioxidantmechanismsbrainhealthandapoptosis AT yongqingliu thebeneficialeffectsofcurcuminonagingandagerelateddiseasesfromoxidativestresstoantioxidantmechanismsbrainhealthandapoptosis AT minzhang thebeneficialeffectsofcurcuminonagingandagerelateddiseasesfromoxidativestresstoantioxidantmechanismsbrainhealthandapoptosis AT yinghe beneficialeffectsofcurcuminonagingandagerelateddiseasesfromoxidativestresstoantioxidantmechanismsbrainhealthandapoptosis AT yinghe beneficialeffectsofcurcuminonagingandagerelateddiseasesfromoxidativestresstoantioxidantmechanismsbrainhealthandapoptosis AT yongqingliu beneficialeffectsofcurcuminonagingandagerelateddiseasesfromoxidativestresstoantioxidantmechanismsbrainhealthandapoptosis AT minzhang beneficialeffectsofcurcuminonagingandagerelateddiseasesfromoxidativestresstoantioxidantmechanismsbrainhealthandapoptosis |