Research Progress on the Role of the Interaction Between Chronic Inflammation and Fibrosis in Diabetic Nephropathy
Diabetic nephropathy (DN), a primary cause of end-stage renal disease (ESRD) in diabetic patients, is pathologically characterized by chronic inflammation and renal fibrosis. Chronic inflammation promotes renal cellular damage, epithelial-mesenchymal transition, and extracellular matrix (ECM) accumu...
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Editorial Office of Medical Journal of Peking Union Medical College Hospital
2025-06-01
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| Series: | Xiehe Yixue Zazhi |
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| Online Access: | https://xhyxzz.pumch.cn/article/doi/10.12290/xhyxzz.2024-1078 |
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| author | XU Jin LI Jianxing LIU Zhenhua ZHANG Xinli |
| author_facet | XU Jin LI Jianxing LIU Zhenhua ZHANG Xinli |
| author_sort | XU Jin |
| collection | DOAJ |
| description | Diabetic nephropathy (DN), a primary cause of end-stage renal disease (ESRD) in diabetic patients, is pathologically characterized by chronic inflammation and renal fibrosis. Chronic inflammation promotes renal cellular damage, epithelial-mesenchymal transition, and extracellular matrix (ECM) accumulation through mechanisms including immune cell activation, pro-inflammatory cytokine secretion, and initiation of multiple signaling pathways. Excessive ECM deposition disrupts renal architecture and drives tubulointerstitial expansion, thereby accelerating renal functional decline. Recent studies demonstrate that chronic inflammation and fibrosis synergistically propagate DN progression via bidirectional crosstalk. Inflammation serves as an early driver of fibrogenesis and further amplifies fibrotic processes through positive feedback mechanisms, establishing a self-perpetuating inflammation-fibrosis vicious cycle. However, the precise molecular interplay between chronic inflammation and fibrosis remains incompletely elucidated. Thus, in-depth exploration of their interaction mechanisms is crucial for developing novel DN interventions. This review delineates the pathogenic roles of chronic inflammation and fibrosis in DN to advance mechanistic understanding and provide foundational insights for designing innovative therapeutic strategies. |
| format | Article |
| id | doaj-art-2ed22b7aee0c4a2697e64d9158d5d889 |
| institution | DOAJ |
| issn | 1674-9081 |
| language | zho |
| publishDate | 2025-06-01 |
| publisher | Editorial Office of Medical Journal of Peking Union Medical College Hospital |
| record_format | Article |
| series | Xiehe Yixue Zazhi |
| spelling | doaj-art-2ed22b7aee0c4a2697e64d9158d5d8892025-08-20T02:58:21ZzhoEditorial Office of Medical Journal of Peking Union Medical College HospitalXiehe Yixue Zazhi1674-90812025-06-0116498098810.12290/xhyxzz.2024-1078Research Progress on the Role of the Interaction Between Chronic Inflammation and Fibrosis in Diabetic NephropathyXU Jin0LI Jianxing1LIU Zhenhua2ZHANG Xinli3Department of Nephrology, Gansu Provincial Hospital of TCM, Lanzhou 730000, ChinaDepartment of Nephrology, Gansu Provincial Hospital of TCM, Lanzhou 730000, ChinaGansu University of Chinese Medicine, Lanzhou 730000, ChinaDepartment of Nephrology, Gansu Provincial Hospital of TCM, Lanzhou 730000, ChinaDiabetic nephropathy (DN), a primary cause of end-stage renal disease (ESRD) in diabetic patients, is pathologically characterized by chronic inflammation and renal fibrosis. Chronic inflammation promotes renal cellular damage, epithelial-mesenchymal transition, and extracellular matrix (ECM) accumulation through mechanisms including immune cell activation, pro-inflammatory cytokine secretion, and initiation of multiple signaling pathways. Excessive ECM deposition disrupts renal architecture and drives tubulointerstitial expansion, thereby accelerating renal functional decline. Recent studies demonstrate that chronic inflammation and fibrosis synergistically propagate DN progression via bidirectional crosstalk. Inflammation serves as an early driver of fibrogenesis and further amplifies fibrotic processes through positive feedback mechanisms, establishing a self-perpetuating inflammation-fibrosis vicious cycle. However, the precise molecular interplay between chronic inflammation and fibrosis remains incompletely elucidated. Thus, in-depth exploration of their interaction mechanisms is crucial for developing novel DN interventions. This review delineates the pathogenic roles of chronic inflammation and fibrosis in DN to advance mechanistic understanding and provide foundational insights for designing innovative therapeutic strategies.https://xhyxzz.pumch.cn/article/doi/10.12290/xhyxzz.2024-1078diabetic nephropathyinflammatory responserenal fibrosisepithelial-mesenchymal transitionextracellular matrixsignal pathway |
| spellingShingle | XU Jin LI Jianxing LIU Zhenhua ZHANG Xinli Research Progress on the Role of the Interaction Between Chronic Inflammation and Fibrosis in Diabetic Nephropathy Xiehe Yixue Zazhi diabetic nephropathy inflammatory response renal fibrosis epithelial-mesenchymal transition extracellular matrix signal pathway |
| title | Research Progress on the Role of the Interaction Between Chronic Inflammation and Fibrosis in Diabetic Nephropathy |
| title_full | Research Progress on the Role of the Interaction Between Chronic Inflammation and Fibrosis in Diabetic Nephropathy |
| title_fullStr | Research Progress on the Role of the Interaction Between Chronic Inflammation and Fibrosis in Diabetic Nephropathy |
| title_full_unstemmed | Research Progress on the Role of the Interaction Between Chronic Inflammation and Fibrosis in Diabetic Nephropathy |
| title_short | Research Progress on the Role of the Interaction Between Chronic Inflammation and Fibrosis in Diabetic Nephropathy |
| title_sort | research progress on the role of the interaction between chronic inflammation and fibrosis in diabetic nephropathy |
| topic | diabetic nephropathy inflammatory response renal fibrosis epithelial-mesenchymal transition extracellular matrix signal pathway |
| url | https://xhyxzz.pumch.cn/article/doi/10.12290/xhyxzz.2024-1078 |
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