Spontaneous Coronary Artery Dissection following Topical Hormone Replacement Therapy

Spontaneous coronary artery dissection is a rare condition, usually presenting as an acute coronary syndrome, and is often seen in states associated with high systemic estrogen levels such as pregnancy or oral contraceptive use. While topical hormonal replacement therapy may result in increased est...

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Main Authors: Alexander L. Pan, David Fergusson, Robert Hong, Ramy A. Badawi
Format: Article
Language:English
Published: Wiley 2012-01-01
Series:Case Reports in Cardiology
Online Access:http://dx.doi.org/10.1155/2012/524508
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author Alexander L. Pan
David Fergusson
Robert Hong
Ramy A. Badawi
author_facet Alexander L. Pan
David Fergusson
Robert Hong
Ramy A. Badawi
author_sort Alexander L. Pan
collection DOAJ
description Spontaneous coronary artery dissection is a rare condition, usually presenting as an acute coronary syndrome, and is often seen in states associated with high systemic estrogen levels such as pregnancy or oral contraceptive use. While topical hormonal replacement therapy may result in increased estrogen levels similar to those documented with oral contraceptive use, there are no reported cases of spontaneous coronary dissection with topical hormonal replacement therapy. We describe a 53-year-old female who developed two spontaneous coronary dissections while on topical hormonal replacement therapy. The patient had no other risk factors for coronary dissection. After withdrawal from topical hormonal therapy, our patient has done well and has not had recurrent coronary artery dissections over a one-year follow-up period. The potential contributory role of topical hormonal therapy as a cause of spontaneous coronary dissection should be recognized.
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series Case Reports in Cardiology
spelling doaj-art-2ed02b34abff4716a9a6e9eba70128ae2025-02-03T06:12:14ZengWileyCase Reports in Cardiology2090-64042090-64122012-01-01201210.1155/2012/524508524508Spontaneous Coronary Artery Dissection following Topical Hormone Replacement TherapyAlexander L. Pan0David Fergusson1Robert Hong2Ramy A. Badawi3Division of Cardiology, The John A. Burns School of Medicine, University of Hawaii, Queens Medical Center, Honolulu, HI 96813, USADivision of Cardiology, The John A. Burns School of Medicine, University of Hawaii, Queens Medical Center, Honolulu, HI 96813, USADivision of Cardiology, The John A. Burns School of Medicine, University of Hawaii, Queens Medical Center, Honolulu, HI 96813, USADivision of Cardiology, The John A. Burns School of Medicine, University of Hawaii, Queens Medical Center, Honolulu, HI 96813, USASpontaneous coronary artery dissection is a rare condition, usually presenting as an acute coronary syndrome, and is often seen in states associated with high systemic estrogen levels such as pregnancy or oral contraceptive use. While topical hormonal replacement therapy may result in increased estrogen levels similar to those documented with oral contraceptive use, there are no reported cases of spontaneous coronary dissection with topical hormonal replacement therapy. We describe a 53-year-old female who developed two spontaneous coronary dissections while on topical hormonal replacement therapy. The patient had no other risk factors for coronary dissection. After withdrawal from topical hormonal therapy, our patient has done well and has not had recurrent coronary artery dissections over a one-year follow-up period. The potential contributory role of topical hormonal therapy as a cause of spontaneous coronary dissection should be recognized.http://dx.doi.org/10.1155/2012/524508
spellingShingle Alexander L. Pan
David Fergusson
Robert Hong
Ramy A. Badawi
Spontaneous Coronary Artery Dissection following Topical Hormone Replacement Therapy
Case Reports in Cardiology
title Spontaneous Coronary Artery Dissection following Topical Hormone Replacement Therapy
title_full Spontaneous Coronary Artery Dissection following Topical Hormone Replacement Therapy
title_fullStr Spontaneous Coronary Artery Dissection following Topical Hormone Replacement Therapy
title_full_unstemmed Spontaneous Coronary Artery Dissection following Topical Hormone Replacement Therapy
title_short Spontaneous Coronary Artery Dissection following Topical Hormone Replacement Therapy
title_sort spontaneous coronary artery dissection following topical hormone replacement therapy
url http://dx.doi.org/10.1155/2012/524508
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