SCRAPPER Regulates the Thresholds of Long-Term Potentiation/Depression, the Bidirectional Synaptic Plasticity in Hippocampal CA3-CA1 Synapses

SCRAPPER, which is an F-box protein encoded by FBXL20, regulates the frequency of the miniature excitatory synaptic current through the ubiquitination of Rab3-interacting molecule 1. Here, we recorded the induction of long-term potentiation/depression (LTP/LTD) in CA3-CA1 synapses in E3 ubiquitin li...

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Main Authors: Hiroshi Takagi, Mitsutoshi Setou, Seiji Ito, Ikuko Yao
Format: Article
Language:English
Published: Wiley 2012-01-01
Series:Neural Plasticity
Online Access:http://dx.doi.org/10.1155/2012/352829
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author Hiroshi Takagi
Mitsutoshi Setou
Seiji Ito
Ikuko Yao
author_facet Hiroshi Takagi
Mitsutoshi Setou
Seiji Ito
Ikuko Yao
author_sort Hiroshi Takagi
collection DOAJ
description SCRAPPER, which is an F-box protein encoded by FBXL20, regulates the frequency of the miniature excitatory synaptic current through the ubiquitination of Rab3-interacting molecule 1. Here, we recorded the induction of long-term potentiation/depression (LTP/LTD) in CA3-CA1 synapses in E3 ubiquitin ligase SCRAPPER-deficient hippocampal slices. Compared to wild-type mice, Scrapper-knockout mice exhibited LTDs with smaller magnitudes after induction with low-frequency stimulation and LTPs with larger magnitudes after induction with tetanus stimulation. These findings suggest that SCRAPPER regulates the threshold of bidirectional synaptic plasticity and, therefore, metaplasticity.
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institution Kabale University
issn 2090-5904
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language English
publishDate 2012-01-01
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record_format Article
series Neural Plasticity
spelling doaj-art-2ecfba70a5c5410ba1c89f6f00ad50712025-02-03T01:10:52ZengWileyNeural Plasticity2090-59041687-54432012-01-01201210.1155/2012/352829352829SCRAPPER Regulates the Thresholds of Long-Term Potentiation/Depression, the Bidirectional Synaptic Plasticity in Hippocampal CA3-CA1 SynapsesHiroshi Takagi0Mitsutoshi Setou1Seiji Ito2Ikuko Yao3Cellular & Molecular Synaptic Function Unit, Initial Research Project, Okinawa Institute of Science and Technology Promotion Corporation, 1919-1, Tancha, Onna 904-0495, JapanMolecular Gerontology Research Group, Mitsubishi Kagaku Institute of Life Sciences (MITILS), 11 Minamiooya, Machida 194-8511, JapanDepartment of Medical Chemistry, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi 570-8506, JapanMolecular Gerontology Research Group, Mitsubishi Kagaku Institute of Life Sciences (MITILS), 11 Minamiooya, Machida 194-8511, JapanSCRAPPER, which is an F-box protein encoded by FBXL20, regulates the frequency of the miniature excitatory synaptic current through the ubiquitination of Rab3-interacting molecule 1. Here, we recorded the induction of long-term potentiation/depression (LTP/LTD) in CA3-CA1 synapses in E3 ubiquitin ligase SCRAPPER-deficient hippocampal slices. Compared to wild-type mice, Scrapper-knockout mice exhibited LTDs with smaller magnitudes after induction with low-frequency stimulation and LTPs with larger magnitudes after induction with tetanus stimulation. These findings suggest that SCRAPPER regulates the threshold of bidirectional synaptic plasticity and, therefore, metaplasticity.http://dx.doi.org/10.1155/2012/352829
spellingShingle Hiroshi Takagi
Mitsutoshi Setou
Seiji Ito
Ikuko Yao
SCRAPPER Regulates the Thresholds of Long-Term Potentiation/Depression, the Bidirectional Synaptic Plasticity in Hippocampal CA3-CA1 Synapses
Neural Plasticity
title SCRAPPER Regulates the Thresholds of Long-Term Potentiation/Depression, the Bidirectional Synaptic Plasticity in Hippocampal CA3-CA1 Synapses
title_full SCRAPPER Regulates the Thresholds of Long-Term Potentiation/Depression, the Bidirectional Synaptic Plasticity in Hippocampal CA3-CA1 Synapses
title_fullStr SCRAPPER Regulates the Thresholds of Long-Term Potentiation/Depression, the Bidirectional Synaptic Plasticity in Hippocampal CA3-CA1 Synapses
title_full_unstemmed SCRAPPER Regulates the Thresholds of Long-Term Potentiation/Depression, the Bidirectional Synaptic Plasticity in Hippocampal CA3-CA1 Synapses
title_short SCRAPPER Regulates the Thresholds of Long-Term Potentiation/Depression, the Bidirectional Synaptic Plasticity in Hippocampal CA3-CA1 Synapses
title_sort scrapper regulates the thresholds of long term potentiation depression the bidirectional synaptic plasticity in hippocampal ca3 ca1 synapses
url http://dx.doi.org/10.1155/2012/352829
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