SCRAPPER Regulates the Thresholds of Long-Term Potentiation/Depression, the Bidirectional Synaptic Plasticity in Hippocampal CA3-CA1 Synapses
SCRAPPER, which is an F-box protein encoded by FBXL20, regulates the frequency of the miniature excitatory synaptic current through the ubiquitination of Rab3-interacting molecule 1. Here, we recorded the induction of long-term potentiation/depression (LTP/LTD) in CA3-CA1 synapses in E3 ubiquitin li...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2012/352829 |
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| _version_ | 1832564457857875968 |
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| author | Hiroshi Takagi Mitsutoshi Setou Seiji Ito Ikuko Yao |
| author_facet | Hiroshi Takagi Mitsutoshi Setou Seiji Ito Ikuko Yao |
| author_sort | Hiroshi Takagi |
| collection | DOAJ |
| description | SCRAPPER, which is an F-box protein encoded by FBXL20, regulates the frequency of the miniature excitatory synaptic current through the ubiquitination of Rab3-interacting molecule 1. Here, we recorded the induction of long-term potentiation/depression (LTP/LTD) in CA3-CA1 synapses in E3 ubiquitin ligase SCRAPPER-deficient hippocampal slices. Compared to wild-type mice, Scrapper-knockout mice exhibited LTDs with smaller magnitudes after induction with low-frequency stimulation and LTPs with larger magnitudes after induction with tetanus stimulation. These findings suggest that SCRAPPER regulates the threshold of bidirectional synaptic plasticity and, therefore, metaplasticity. |
| format | Article |
| id | doaj-art-2ecfba70a5c5410ba1c89f6f00ad5071 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-2ecfba70a5c5410ba1c89f6f00ad50712025-02-03T01:10:52ZengWileyNeural Plasticity2090-59041687-54432012-01-01201210.1155/2012/352829352829SCRAPPER Regulates the Thresholds of Long-Term Potentiation/Depression, the Bidirectional Synaptic Plasticity in Hippocampal CA3-CA1 SynapsesHiroshi Takagi0Mitsutoshi Setou1Seiji Ito2Ikuko Yao3Cellular & Molecular Synaptic Function Unit, Initial Research Project, Okinawa Institute of Science and Technology Promotion Corporation, 1919-1, Tancha, Onna 904-0495, JapanMolecular Gerontology Research Group, Mitsubishi Kagaku Institute of Life Sciences (MITILS), 11 Minamiooya, Machida 194-8511, JapanDepartment of Medical Chemistry, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi 570-8506, JapanMolecular Gerontology Research Group, Mitsubishi Kagaku Institute of Life Sciences (MITILS), 11 Minamiooya, Machida 194-8511, JapanSCRAPPER, which is an F-box protein encoded by FBXL20, regulates the frequency of the miniature excitatory synaptic current through the ubiquitination of Rab3-interacting molecule 1. Here, we recorded the induction of long-term potentiation/depression (LTP/LTD) in CA3-CA1 synapses in E3 ubiquitin ligase SCRAPPER-deficient hippocampal slices. Compared to wild-type mice, Scrapper-knockout mice exhibited LTDs with smaller magnitudes after induction with low-frequency stimulation and LTPs with larger magnitudes after induction with tetanus stimulation. These findings suggest that SCRAPPER regulates the threshold of bidirectional synaptic plasticity and, therefore, metaplasticity.http://dx.doi.org/10.1155/2012/352829 |
| spellingShingle | Hiroshi Takagi Mitsutoshi Setou Seiji Ito Ikuko Yao SCRAPPER Regulates the Thresholds of Long-Term Potentiation/Depression, the Bidirectional Synaptic Plasticity in Hippocampal CA3-CA1 Synapses Neural Plasticity |
| title | SCRAPPER Regulates the Thresholds of Long-Term Potentiation/Depression, the Bidirectional Synaptic Plasticity in Hippocampal CA3-CA1 Synapses |
| title_full | SCRAPPER Regulates the Thresholds of Long-Term Potentiation/Depression, the Bidirectional Synaptic Plasticity in Hippocampal CA3-CA1 Synapses |
| title_fullStr | SCRAPPER Regulates the Thresholds of Long-Term Potentiation/Depression, the Bidirectional Synaptic Plasticity in Hippocampal CA3-CA1 Synapses |
| title_full_unstemmed | SCRAPPER Regulates the Thresholds of Long-Term Potentiation/Depression, the Bidirectional Synaptic Plasticity in Hippocampal CA3-CA1 Synapses |
| title_short | SCRAPPER Regulates the Thresholds of Long-Term Potentiation/Depression, the Bidirectional Synaptic Plasticity in Hippocampal CA3-CA1 Synapses |
| title_sort | scrapper regulates the thresholds of long term potentiation depression the bidirectional synaptic plasticity in hippocampal ca3 ca1 synapses |
| url | http://dx.doi.org/10.1155/2012/352829 |
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