The Functions of Major Gut Microbiota in Obesity and Type 2 Diabetes
<b>Background:</b> Gut microbiomes play a vital role in maintaining whole-body metabolic homeostasis. It has gained significant attention in recent years due to advancements in genome sequencing technologies and a deeper understanding of its relationship with obesity. However, the specif...
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MDPI AG
2025-03-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/15/3/167 |
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| author | Siman Liu Zhipeng Tao Mingyu Qiao Limin Shi |
| author_facet | Siman Liu Zhipeng Tao Mingyu Qiao Limin Shi |
| author_sort | Siman Liu |
| collection | DOAJ |
| description | <b>Background:</b> Gut microbiomes play a vital role in maintaining whole-body metabolic homeostasis. It has gained significant attention in recent years due to advancements in genome sequencing technologies and a deeper understanding of its relationship with obesity. However, the specific ways in which different microorganisms directly or indirectly influence host obesity, as well as the underlying mechanisms, remain uncertain because of the complexity of gut microbiota composition. <b>Methods:</b> In this review, we summarize the roles of the major gut microbiota phyla such as <i>Bacteroidetes</i>, <i>Firmicutes</i>, <i>Proteobacteria</i>, and <i>Verrucomicrobia</i> in obesity and type 2 diabetes based on studies published in the past five years on PubMed and Google Scholar. The current therapeutic strategies associated with gut microbiota are also explored from clinical trials, and challenges and future directions are discussed. <b>Results and Conclusions:</b> This review will provide a deeper understanding of the functions of major gut microbiota in obesity and type 2 diabetes, which could lead to more individualized and effective treatments for metabolic diseases. |
| format | Article |
| id | doaj-art-2ececd0baa0d413ba8574aebc7f3001f |
| institution | DOAJ |
| issn | 2218-1989 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj-art-2ececd0baa0d413ba8574aebc7f3001f2025-08-20T02:42:26ZengMDPI AGMetabolites2218-19892025-03-0115316710.3390/metabo15030167The Functions of Major Gut Microbiota in Obesity and Type 2 DiabetesSiman Liu0Zhipeng Tao1Mingyu Qiao2Limin Shi3Departments of Nutritional Science, University of Connecticut, Storrs, CT 06269, USADepartment of Nutrition and Food Sciences, Texas Woman’s University, Denton, TX 76204, USADepartments of Nutritional Science, University of Connecticut, Storrs, CT 06269, USADepartments of Medicine and Biological Chemistry, Johns Hopkins University School of Medicine, Institute for Fundamental Biomedical Research, Johns Hopkins All Children’s Hospital, St. Petersburg, FL 33701, USA<b>Background:</b> Gut microbiomes play a vital role in maintaining whole-body metabolic homeostasis. It has gained significant attention in recent years due to advancements in genome sequencing technologies and a deeper understanding of its relationship with obesity. However, the specific ways in which different microorganisms directly or indirectly influence host obesity, as well as the underlying mechanisms, remain uncertain because of the complexity of gut microbiota composition. <b>Methods:</b> In this review, we summarize the roles of the major gut microbiota phyla such as <i>Bacteroidetes</i>, <i>Firmicutes</i>, <i>Proteobacteria</i>, and <i>Verrucomicrobia</i> in obesity and type 2 diabetes based on studies published in the past five years on PubMed and Google Scholar. The current therapeutic strategies associated with gut microbiota are also explored from clinical trials, and challenges and future directions are discussed. <b>Results and Conclusions:</b> This review will provide a deeper understanding of the functions of major gut microbiota in obesity and type 2 diabetes, which could lead to more individualized and effective treatments for metabolic diseases.https://www.mdpi.com/2218-1989/15/3/167gut microbiome<i>Bacteroidetes</i><i>Firmicutes</i><i>Proteobacteria</i><i>Verrucomicrobia</i>clinical trial |
| spellingShingle | Siman Liu Zhipeng Tao Mingyu Qiao Limin Shi The Functions of Major Gut Microbiota in Obesity and Type 2 Diabetes Metabolites gut microbiome <i>Bacteroidetes</i> <i>Firmicutes</i> <i>Proteobacteria</i> <i>Verrucomicrobia</i> clinical trial |
| title | The Functions of Major Gut Microbiota in Obesity and Type 2 Diabetes |
| title_full | The Functions of Major Gut Microbiota in Obesity and Type 2 Diabetes |
| title_fullStr | The Functions of Major Gut Microbiota in Obesity and Type 2 Diabetes |
| title_full_unstemmed | The Functions of Major Gut Microbiota in Obesity and Type 2 Diabetes |
| title_short | The Functions of Major Gut Microbiota in Obesity and Type 2 Diabetes |
| title_sort | functions of major gut microbiota in obesity and type 2 diabetes |
| topic | gut microbiome <i>Bacteroidetes</i> <i>Firmicutes</i> <i>Proteobacteria</i> <i>Verrucomicrobia</i> clinical trial |
| url | https://www.mdpi.com/2218-1989/15/3/167 |
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