Mpox: Characterization and clinical outcomes of patients in Colombian healthcare institutions
Introduction: In 2022, the world experienced a monkeypox outbreak caused by the Clade IIb strain of the virus. While this outbreak had widespread effects, more information is needed on mpox's specific impact in Colombia, particularly regarding how it is managed, its burden, and its epidemiology...
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Elsevier
2025-06-01
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| Series: | Global Epidemiology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S259011332500015X |
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| author | Carlos Arturo Álvarez-Moreno Ludovic Reveiz Claudia Aristizabal Jesús Quevedo María Lucia Mesa Rubio Leonardo Arévalo-Mora Julián Felipe Porras Villamil Monica Padilla Juan Carlos Alzate-Angel Jamie Rylance Kurbonov Firdavs Ilich de la Hoz Sandra Liliana Valderrama-Beltran Santiago Arboleda Otto Sussmann Javier Andrade Carolina Murillo Velásquez Estefania García Ximena Galindo Daniela Martínez Lisandra Arango Ernesto Martínez Karyna Reyes-Caicedo Mónica Mantilla Suarez Juana Gutiérrez Ríos Alexandra Garay Wendy Pinzón Ana María Crispin Antoine Chaillon |
| author_facet | Carlos Arturo Álvarez-Moreno Ludovic Reveiz Claudia Aristizabal Jesús Quevedo María Lucia Mesa Rubio Leonardo Arévalo-Mora Julián Felipe Porras Villamil Monica Padilla Juan Carlos Alzate-Angel Jamie Rylance Kurbonov Firdavs Ilich de la Hoz Sandra Liliana Valderrama-Beltran Santiago Arboleda Otto Sussmann Javier Andrade Carolina Murillo Velásquez Estefania García Ximena Galindo Daniela Martínez Lisandra Arango Ernesto Martínez Karyna Reyes-Caicedo Mónica Mantilla Suarez Juana Gutiérrez Ríos Alexandra Garay Wendy Pinzón Ana María Crispin Antoine Chaillon |
| author_sort | Carlos Arturo Álvarez-Moreno |
| collection | DOAJ |
| description | Introduction: In 2022, the world experienced a monkeypox outbreak caused by the Clade IIb strain of the virus. While this outbreak had widespread effects, more information is needed on mpox's specific impact in Colombia, particularly regarding how it is managed, its burden, and its epidemiology. This research seeks to examine the medical context, clinical presentation, and health outcomes of individuals diagnosed with mpox infection, with a particular focus on those with HIV in Colombia. Methods: This retrospective study was conducted in fourteen Health institutions in Colombia based on computerized clinical records from Jan 2022 to Dec 2023. Clinical and epidemiological characteristics were collected from diagnosis until discharge (or death). Participants in the study were diagnosed through molecular methods (PCR) and their clinical evolution was tracked through hospital and/or outpatient medical records. Registered variables were based on the mpox 2023 Case Report Form (2023 - CRF) proposed by the World Health Organization. Results: One thousand four hundred thirteen (1413, 97.2 % male) individuals, including 2.6 % identified as healthcare workers, were included in this study. The majority (54 %, 764/1413 individuals) were persons living with HIV (PWH) and almost one-third of them (30.1 %, n = 284) of participants had concomitant sexually transmitted diseases and HIV, with syphilis being the most prevalent (20.4 %), followed by Neisseria gonorrhoeae (16.4 %). Complications were infrequent, with cellulitis being the most common, and no individuals received mpox-specific treatment or vaccination. Although all individuals had skin lesions distributed across various body regions, differences were noted in lesion distribution among women. Those living with HIV showed higher emergency department attendance and reported having known mpox contacts. While complications were rare, with cellulitis being the most common, women living with HIV showed a higher rate of emergency room visits and known mpox contacts. Although not statistically significant, gastrointestinal, musculoskeletal, psychological, respiratory, and STI symptoms, including syphilis and urethritis, were more common in the virologically non-suppressed HIV group. At the same time, proctitis was more prevalent in the suppressed group. No significant differences were found based on CD4 count, using 200 cells/mm3 in PWH. Conclusion: Over half of the participants were people living with HIV (PWH), with a significant presence of STIs like syphilis. While skin lesions and complications varied, no significant differences were linked to CD4 count or viral load suppression. Mpox symptomatology was not significantly associated with unsuppressed viral loads or low CD4 levels, highlighting the need for further research. |
| format | Article |
| id | doaj-art-2ece7102a39b493f837cfb98bcbba610 |
| institution | DOAJ |
| issn | 2590-1133 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Global Epidemiology |
| spelling | doaj-art-2ece7102a39b493f837cfb98bcbba6102025-08-20T03:21:18ZengElsevierGlobal Epidemiology2590-11332025-06-01910019710.1016/j.gloepi.2025.100197Mpox: Characterization and clinical outcomes of patients in Colombian healthcare institutionsCarlos Arturo Álvarez-Moreno0Ludovic Reveiz1Claudia Aristizabal2Jesús Quevedo3María Lucia Mesa Rubio4Leonardo Arévalo-Mora5Julián Felipe Porras Villamil6Monica Padilla7Juan Carlos Alzate-Angel8Jamie Rylance9Kurbonov Firdavs10Ilich de la Hoz11Sandra Liliana Valderrama-Beltran12Santiago Arboleda13Otto Sussmann14Javier Andrade15Carolina Murillo Velásquez16Estefania García17Ximena Galindo18Daniela Martínez19Lisandra Arango20Ernesto Martínez21Karyna Reyes-Caicedo22Mónica Mantilla Suarez23Juana Gutiérrez Ríos24Alexandra Garay25Wendy Pinzón26Ana María Crispin27Antoine Chaillon28Clínica Universitaria Colombia, Clínica Colsanitas, Universidad Nacional de Colombia, Bogota, ColombiaPan American Health OrganizationUnisanitas, Bogota, ColombiaCentros médicos Keralty, ColombiaPan American Health OrganizationPan American Health Organization; Corresponding author.Pan American Health OrganizationPan American Health OrganizationInstituto de Evaluación Tecnológica en Salud (IETS), Bogota, ColombiaWorld Health OrganizationWorld Health OrganizationWorld Health OrganizationHospital Universitario San Ignacio, Pontificia Universidad Javeriana, Bogota, ColombiaHospital Universitario San Ignacio, Pontificia Universidad Javeriana, Bogota, ColombiaInfectoclinicos IPS, Bogota, ColombiaInfectoclinicos IPS, Bogota, ColombiaHospital La María, Medellin, ColombiaHospital La María, Medellin, ColombiaCorporación de Lucha contra el Sida, Cali, ColombiaHospital Alma Mater de Antioquia, Medellin, ColombiaHospital Alma Mater de Antioquia, Medellin, ColombiaHospital Universitario del Valle, Universidad del Valle, Cali, ColombiaHospital Universitario del Valle, Universidad del Valle, Cali, ColombiaVirrey Solís IPS, Bogota, ColombiaVirrey Solís IPS, Bogota, ColombiaClínica de La Sabana, Bogota, ColombiaClínica de La Sabana, Bogota, ColombiaClínica de La Sabana, Bogota, ColombiaWorld Health OrganizationIntroduction: In 2022, the world experienced a monkeypox outbreak caused by the Clade IIb strain of the virus. While this outbreak had widespread effects, more information is needed on mpox's specific impact in Colombia, particularly regarding how it is managed, its burden, and its epidemiology. This research seeks to examine the medical context, clinical presentation, and health outcomes of individuals diagnosed with mpox infection, with a particular focus on those with HIV in Colombia. Methods: This retrospective study was conducted in fourteen Health institutions in Colombia based on computerized clinical records from Jan 2022 to Dec 2023. Clinical and epidemiological characteristics were collected from diagnosis until discharge (or death). Participants in the study were diagnosed through molecular methods (PCR) and their clinical evolution was tracked through hospital and/or outpatient medical records. Registered variables were based on the mpox 2023 Case Report Form (2023 - CRF) proposed by the World Health Organization. Results: One thousand four hundred thirteen (1413, 97.2 % male) individuals, including 2.6 % identified as healthcare workers, were included in this study. The majority (54 %, 764/1413 individuals) were persons living with HIV (PWH) and almost one-third of them (30.1 %, n = 284) of participants had concomitant sexually transmitted diseases and HIV, with syphilis being the most prevalent (20.4 %), followed by Neisseria gonorrhoeae (16.4 %). Complications were infrequent, with cellulitis being the most common, and no individuals received mpox-specific treatment or vaccination. Although all individuals had skin lesions distributed across various body regions, differences were noted in lesion distribution among women. Those living with HIV showed higher emergency department attendance and reported having known mpox contacts. While complications were rare, with cellulitis being the most common, women living with HIV showed a higher rate of emergency room visits and known mpox contacts. Although not statistically significant, gastrointestinal, musculoskeletal, psychological, respiratory, and STI symptoms, including syphilis and urethritis, were more common in the virologically non-suppressed HIV group. At the same time, proctitis was more prevalent in the suppressed group. No significant differences were found based on CD4 count, using 200 cells/mm3 in PWH. Conclusion: Over half of the participants were people living with HIV (PWH), with a significant presence of STIs like syphilis. While skin lesions and complications varied, no significant differences were linked to CD4 count or viral load suppression. Mpox symptomatology was not significantly associated with unsuppressed viral loads or low CD4 levels, highlighting the need for further research.http://www.sciencedirect.com/science/article/pii/S259011332500015XMpoxMonkeypoxOutbreakColombiaComplicationsHIV |
| spellingShingle | Carlos Arturo Álvarez-Moreno Ludovic Reveiz Claudia Aristizabal Jesús Quevedo María Lucia Mesa Rubio Leonardo Arévalo-Mora Julián Felipe Porras Villamil Monica Padilla Juan Carlos Alzate-Angel Jamie Rylance Kurbonov Firdavs Ilich de la Hoz Sandra Liliana Valderrama-Beltran Santiago Arboleda Otto Sussmann Javier Andrade Carolina Murillo Velásquez Estefania García Ximena Galindo Daniela Martínez Lisandra Arango Ernesto Martínez Karyna Reyes-Caicedo Mónica Mantilla Suarez Juana Gutiérrez Ríos Alexandra Garay Wendy Pinzón Ana María Crispin Antoine Chaillon Mpox: Characterization and clinical outcomes of patients in Colombian healthcare institutions Global Epidemiology Mpox Monkeypox Outbreak Colombia Complications HIV |
| title | Mpox: Characterization and clinical outcomes of patients in Colombian healthcare institutions |
| title_full | Mpox: Characterization and clinical outcomes of patients in Colombian healthcare institutions |
| title_fullStr | Mpox: Characterization and clinical outcomes of patients in Colombian healthcare institutions |
| title_full_unstemmed | Mpox: Characterization and clinical outcomes of patients in Colombian healthcare institutions |
| title_short | Mpox: Characterization and clinical outcomes of patients in Colombian healthcare institutions |
| title_sort | mpox characterization and clinical outcomes of patients in colombian healthcare institutions |
| topic | Mpox Monkeypox Outbreak Colombia Complications HIV |
| url | http://www.sciencedirect.com/science/article/pii/S259011332500015X |
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