Ex vivo delivery of recombinant IL-10 to human donor lungs

Ex vivo delivery of recombinant IL-10 to human donor lungs

Background: The immunoregulatory cytokine interleukin-10 (IL-10) has been shown to be a promising therapy for donor lung injuries before transplantation. However, the very short half-life of IL-10 in vivo (∼2 hours) has necessitated the use of gene therapy in almost all animal models of lung transpl...

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Bibliographic Details
Main Authors: Jonathan C. Yeung, Terumoto Koike, Dirk Wagnetz, Tiago N. Machuca, Riccardo Bonato, Mingyao Liu, Stephen Juvet, Marcelo Cypel, Shaf Keshavjee
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:JHLT Open
Subjects:
lung transplantation
ex vivo lung perfusion
interleukin-10
drug delivery
aerosol mechanics
Online Access:http://www.sciencedirect.com/science/article/pii/S2950133424001411
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