Relapsed Acute Lymphoblastic Leukemia Presenting as Acute Renal Failure
Acute lymphoblastic leukemia (ALL) is the second most common acute leukemia in adults. It is an aggressive hematologic neoplasm, with a bimodal age distribution typically presenting in childhood and the 6th decade of life (Terwilliger and Abdul-Hay, 2017). Renal injury in ALL is common and can occur...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2019/7913027 |
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| author | Ashley Rose Samuel Slone Eric Padron |
| author_facet | Ashley Rose Samuel Slone Eric Padron |
| author_sort | Ashley Rose |
| collection | DOAJ |
| description | Acute lymphoblastic leukemia (ALL) is the second most common acute leukemia in adults. It is an aggressive hematologic neoplasm, with a bimodal age distribution typically presenting in childhood and the 6th decade of life (Terwilliger and Abdul-Hay, 2017). Renal injury in ALL is common and can occur through many different mechanisms, such as prerenal acute kidney injury, acute tubular necrosis, renovascular disease, obstruction, glomerulonephritis, and parenchymal infiltration of tumor cells (Luciano and Brewster, 2014). Infiltration of kidneys by leukemia cells is common; however a resultant injury only occurs in about 1% of patients, and renal failure is even more rare (Luciano and Brewster, 2014). Renal failure due to bilateral infiltration of tumor cells has been reported in only a few cases and is thought to be a poor prognostic indicator (Luciano and Brewster, 2014; Sherief et al., 2015). Biopsy is essential to the diagnosis of renal infiltration of leukemia. We present a case of acute renal failure secondary to bilateral renal infiltration of ALL presenting as the first sign of relapse in a young man. |
| format | Article |
| id | doaj-art-2ec7113d4ad849c4a4b295243eac26da |
| institution | Kabale University |
| issn | 2090-6641 2090-665X |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Nephrology |
| spelling | doaj-art-2ec7113d4ad849c4a4b295243eac26da2025-02-03T01:11:22ZengWileyCase Reports in Nephrology2090-66412090-665X2019-01-01201910.1155/2019/79130277913027Relapsed Acute Lymphoblastic Leukemia Presenting as Acute Renal FailureAshley Rose0Samuel Slone1Eric Padron2Internal Medicine, University of South Florida, Tampa, FL 33602, USAInternal Medicine, University of South Florida, Tampa, FL 33602, USAMalignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33602, USAAcute lymphoblastic leukemia (ALL) is the second most common acute leukemia in adults. It is an aggressive hematologic neoplasm, with a bimodal age distribution typically presenting in childhood and the 6th decade of life (Terwilliger and Abdul-Hay, 2017). Renal injury in ALL is common and can occur through many different mechanisms, such as prerenal acute kidney injury, acute tubular necrosis, renovascular disease, obstruction, glomerulonephritis, and parenchymal infiltration of tumor cells (Luciano and Brewster, 2014). Infiltration of kidneys by leukemia cells is common; however a resultant injury only occurs in about 1% of patients, and renal failure is even more rare (Luciano and Brewster, 2014). Renal failure due to bilateral infiltration of tumor cells has been reported in only a few cases and is thought to be a poor prognostic indicator (Luciano and Brewster, 2014; Sherief et al., 2015). Biopsy is essential to the diagnosis of renal infiltration of leukemia. We present a case of acute renal failure secondary to bilateral renal infiltration of ALL presenting as the first sign of relapse in a young man.http://dx.doi.org/10.1155/2019/7913027 |
| spellingShingle | Ashley Rose Samuel Slone Eric Padron Relapsed Acute Lymphoblastic Leukemia Presenting as Acute Renal Failure Case Reports in Nephrology |
| title | Relapsed Acute Lymphoblastic Leukemia Presenting as Acute Renal Failure |
| title_full | Relapsed Acute Lymphoblastic Leukemia Presenting as Acute Renal Failure |
| title_fullStr | Relapsed Acute Lymphoblastic Leukemia Presenting as Acute Renal Failure |
| title_full_unstemmed | Relapsed Acute Lymphoblastic Leukemia Presenting as Acute Renal Failure |
| title_short | Relapsed Acute Lymphoblastic Leukemia Presenting as Acute Renal Failure |
| title_sort | relapsed acute lymphoblastic leukemia presenting as acute renal failure |
| url | http://dx.doi.org/10.1155/2019/7913027 |
| work_keys_str_mv | AT ashleyrose relapsedacutelymphoblasticleukemiapresentingasacuterenalfailure AT samuelslone relapsedacutelymphoblasticleukemiapresentingasacuterenalfailure AT ericpadron relapsedacutelymphoblasticleukemiapresentingasacuterenalfailure |