Comparison of tumor‐informed and tumor‐naïve sequencing assays for ctDNA detection in breast cancer

Comparison of tumor‐informed and tumor‐naïve sequencing assays for ctDNA detection in breast cancer

Abstract Analysis of circulating tumor DNA (ctDNA) to monitor cancer dynamics and detect minimal residual disease has been an area of increasing interest. Multiple methods have been proposed but few studies have compared the performance of different approaches. Here, we compare detection of ctDNA in...

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Main Authors: Angela Santonja, Wendy N Cooper, Matthew D Eldridge, Paul A W Edwards, James A Morris, Abigail R Edwards, Hui Zhao, Katrin Heider, Dominique‐Laurent Couturier, Aadhitthya Vijayaraghavan, Paulius Mennea, Emma‐Jane Ditter, Christopher G Smith, Chris Boursnell, Raquel Manzano García, Oscar M Rueda, Emma Beddowes, Heather Biggs, Stephen‐John Sammut, Nitzan Rosenfeld, Carlos Caldas, Jean E Abraham, Davina Gale
Format: Article
Language:English
Published: Springer Nature 2023-05-01
Series:EMBO Molecular Medicine
Subjects:
circulating tumor DNA
liquid biopsy
hybrid capture
multiplex PCR
whole‐genome sequencing
Online Access:https://doi.org/10.15252/emmm.202216505
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