FRRS1L variants and ferriheme overload drive hyperpigmentation and systemic Iron overload in lanping black bone sheep

FRRS1L variants and ferriheme overload drive hyperpigmentation and systemic Iron overload in lanping black bone sheep

Abstract Background Hemoglobin metabolism disorder can result in systemic iron overload, leading to pigmentation in multiple organs. Although these disorders are often of genetic origin, the specific genes and mechanisms remain incompletely understood. Lanping black bone sheep (LP–BBS), a unique pop...

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Main Authors: Deping Han, Yuanyuan Zhang, Weidong Deng, Xue Yang, Jianfei Chen, Guoying Hua, Hesham Y.A. Darwish, Huaming Mao, Xiao Gou, Jiankui Wang, Kai Cui, Yuhao Ma, Yurong Tai, Xianggui Dong, Yanzhu Yao, Zu Yang, Suying Cao, Zhengquan Yu, Wansheng Liu, Xuemei Deng
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Cell & Bioscience
Subjects:
Black bone sheep
Hyperpigmentation
Iron overload
Macrophage
Systemic inflammation
Online Access:https://doi.org/10.1186/s13578-025-01426-6
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