Effects of genetic mutations on left ventricular myocardial mechanics and fibrosis patterns in hypertrophic cardiomyopathy

Effects of genetic mutations on left ventricular myocardial mechanics and fibrosis patterns in hypertrophic cardiomyopathy

Abstract Myocyte disarray and fibrosis are underlying pathologies of hypertrophic cardiomyopathy (HCM) caused by genetic mutations. However, the extent of their contributions has not been extensively evaluated. In this study, we investigated the effects of genetic mutations on myofiber function and...

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Bibliographic Details
Main Authors: Minjeong Kim, Yoonjung Kim, Hyemoon Chung, Jiwon Seo, Chul Hwan Park, Tae Hoon Kim, Se-Joong Rim, Kyung-A Lee, Eui-Young Choi
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Hypertrophic cardiomyopathy
Genetics
Myofiber
Fibrosis
Online Access:https://doi.org/10.1038/s41598-025-85201-0
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