Brief biology and pathophysiology of Tekt bundles
Tektins, a family of microtubule-stabilizing proteins, are critical for cilia and flagella assembly in mammals. They maintain doublet microtubule stability and ciliary/flagellar motility. Loss of Tekt1–5 causes microtubule instability, impaired motility, and diseases like infertility, retinal degene...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Cell Adhesion & Migration |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19336918.2025.2465421 |
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| author | Jun Yin Min Liu Xiao Wang Hongming Miao Wenjuan He Wei Liu Zhongying Yu Qinghua Zhang Jialian Bai Yimei Cheng Bing Ni |
| author_facet | Jun Yin Min Liu Xiao Wang Hongming Miao Wenjuan He Wei Liu Zhongying Yu Qinghua Zhang Jialian Bai Yimei Cheng Bing Ni |
| author_sort | Jun Yin |
| collection | DOAJ |
| description | Tektins, a family of microtubule-stabilizing proteins, are critical for cilia and flagella assembly in mammals. They maintain doublet microtubule stability and ciliary/flagellar motility. Loss of Tekt1–5 causes microtubule instability, impaired motility, and diseases like infertility, retinal degeneration, Mainzer-Saldino syndrome, and diabetic nephropathy. Pathophysiological stimuli regulate Tektin expression through transcriptional, posttranscriptional, translational, and posttranslational modifications. This review summarizes the latest findings on Tektin functions and their role in diseases. |
| format | Article |
| id | doaj-art-2eb5c7476d4b46f281a7fdabb6e0f39a |
| institution | DOAJ |
| issn | 1933-6918 1933-6926 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Cell Adhesion & Migration |
| spelling | doaj-art-2eb5c7476d4b46f281a7fdabb6e0f39a2025-08-20T03:12:20ZengTaylor & Francis GroupCell Adhesion & Migration1933-69181933-69262025-12-0119110.1080/19336918.2025.2465421Brief biology and pathophysiology of Tekt bundlesJun Yin0Min Liu1Xiao Wang2Hongming Miao3Wenjuan He4Wei Liu5Zhongying Yu6Qinghua Zhang7Jialian Bai8Yimei Cheng9Bing Ni10Department of Pathophysiology, College of High Altitude Military Medicine, Army Medical University, Chongqing, ChinaDepartment of Infectious Diseases, Chongqing Public Health Medical Center, Chongqing, ChinaDepartment of Pathophysiology, College of High Altitude Military Medicine, Army Medical University, Chongqing, ChinaDepartment of Pathophysiology, College of High Altitude Military Medicine, Army Medical University, Chongqing, ChinaDepartment of Pathophysiology, College of High Altitude Military Medicine, Army Medical University, Chongqing, ChinaDepartment of Immunology, Army Medical University, Chongqing, ChinaDepartment of Urology, The 909th Hospital, School of Medicine, Xiamen University, Zhangzhou, ChinaReproductive Medical Center, Daping Hospital, Army Medical University, Chongqing, ChinaSchool of Artificial Intelligence and Big Data, Chongqing Industry Polytechnic College, Chongqing, ChinaDepartment of Pharmacy, Southwest Hospital, Army Medical University, Chongqing, ChinaDepartment of Pathophysiology, College of High Altitude Military Medicine, Army Medical University, Chongqing, ChinaTektins, a family of microtubule-stabilizing proteins, are critical for cilia and flagella assembly in mammals. They maintain doublet microtubule stability and ciliary/flagellar motility. Loss of Tekt1–5 causes microtubule instability, impaired motility, and diseases like infertility, retinal degeneration, Mainzer-Saldino syndrome, and diabetic nephropathy. Pathophysiological stimuli regulate Tektin expression through transcriptional, posttranscriptional, translational, and posttranslational modifications. This review summarizes the latest findings on Tektin functions and their role in diseases.https://www.tandfonline.com/doi/10.1080/19336918.2025.2465421Ciliaflagellamicrotubule inner proteinsTekt bundleCiliopathies |
| spellingShingle | Jun Yin Min Liu Xiao Wang Hongming Miao Wenjuan He Wei Liu Zhongying Yu Qinghua Zhang Jialian Bai Yimei Cheng Bing Ni Brief biology and pathophysiology of Tekt bundles Cell Adhesion & Migration Cilia flagella microtubule inner proteins Tekt bundle Ciliopathies |
| title | Brief biology and pathophysiology of Tekt bundles |
| title_full | Brief biology and pathophysiology of Tekt bundles |
| title_fullStr | Brief biology and pathophysiology of Tekt bundles |
| title_full_unstemmed | Brief biology and pathophysiology of Tekt bundles |
| title_short | Brief biology and pathophysiology of Tekt bundles |
| title_sort | brief biology and pathophysiology of tekt bundles |
| topic | Cilia flagella microtubule inner proteins Tekt bundle Ciliopathies |
| url | https://www.tandfonline.com/doi/10.1080/19336918.2025.2465421 |
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