Immunotherapy combined with chemotherapy: a promising therapeutic approach in the management of colonic squamous cell carcinoma—a case report
Colorectal squamous cell carcinoma (CSCC) is an exceedingly rare malignancy, accounting for approximately 0.41% of all colorectal cancers. This case report describes a 52-year-old male with a history of chronic bronchitis, varicose vein of the lower limb, diabetes, and Hepatitis B cirrhosis, who pre...
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1548008/full |
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| author | Bingbing Ren Haitao Yang Yingying Mao |
| author_facet | Bingbing Ren Haitao Yang Yingying Mao |
| author_sort | Bingbing Ren |
| collection | DOAJ |
| description | Colorectal squamous cell carcinoma (CSCC) is an exceedingly rare malignancy, accounting for approximately 0.41% of all colorectal cancers. This case report describes a 52-year-old male with a history of chronic bronchitis, varicose vein of the lower limb, diabetes, and Hepatitis B cirrhosis, who presented with worsening abdominal pain. The patient underwent a right hemicolectomy, and postoperative pathology revealed a moderately differentiated CSCC with proficient mismatch repair (pMMR) status. The patient was initially treated with the CAPEOX adjuvant chemotherapy regimen, the patient’s condition unfortunately progressed. Therefore, the treatment plan has been adjusted to include nab-paclitaxel and carboplatin, in combination with camrelizumab, an Anti-PD-1 therapy, for antitumor therapy. The combination therapy resulted in a partial response. This case highlights the potential efficacy of Anti-PD-1 therapy combined with chemotherapy in CSCC, suggesting a possible treatment approach for this rare cancer subtype. |
| format | Article |
| id | doaj-art-2eb43f59407445f0a79d786b5e8e76ed |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-2eb43f59407445f0a79d786b5e8e76ed2025-08-20T03:53:06ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-05-011510.3389/fonc.2025.15480081548008Immunotherapy combined with chemotherapy: a promising therapeutic approach in the management of colonic squamous cell carcinoma—a case reportBingbing Ren0Haitao Yang1Yingying Mao2Department of Pediatric Surgery, General Hospital, Tianjin Medical University, Tianjin, ChinaDepartment of General Practice, Liaocheng People’s Hospital, Liaocheng, Shandong, ChinaDepartment of General Practice, Liaocheng People’s Hospital, Liaocheng, Shandong, ChinaColorectal squamous cell carcinoma (CSCC) is an exceedingly rare malignancy, accounting for approximately 0.41% of all colorectal cancers. This case report describes a 52-year-old male with a history of chronic bronchitis, varicose vein of the lower limb, diabetes, and Hepatitis B cirrhosis, who presented with worsening abdominal pain. The patient underwent a right hemicolectomy, and postoperative pathology revealed a moderately differentiated CSCC with proficient mismatch repair (pMMR) status. The patient was initially treated with the CAPEOX adjuvant chemotherapy regimen, the patient’s condition unfortunately progressed. Therefore, the treatment plan has been adjusted to include nab-paclitaxel and carboplatin, in combination with camrelizumab, an Anti-PD-1 therapy, for antitumor therapy. The combination therapy resulted in a partial response. This case highlights the potential efficacy of Anti-PD-1 therapy combined with chemotherapy in CSCC, suggesting a possible treatment approach for this rare cancer subtype.https://www.frontiersin.org/articles/10.3389/fonc.2025.1548008/fullcolorectal cancersquamous cell carcinomaanti-PD-1 therapymicrosatellite instabilitycase report |
| spellingShingle | Bingbing Ren Haitao Yang Yingying Mao Immunotherapy combined with chemotherapy: a promising therapeutic approach in the management of colonic squamous cell carcinoma—a case report Frontiers in Oncology colorectal cancer squamous cell carcinoma anti-PD-1 therapy microsatellite instability case report |
| title | Immunotherapy combined with chemotherapy: a promising therapeutic approach in the management of colonic squamous cell carcinoma—a case report |
| title_full | Immunotherapy combined with chemotherapy: a promising therapeutic approach in the management of colonic squamous cell carcinoma—a case report |
| title_fullStr | Immunotherapy combined with chemotherapy: a promising therapeutic approach in the management of colonic squamous cell carcinoma—a case report |
| title_full_unstemmed | Immunotherapy combined with chemotherapy: a promising therapeutic approach in the management of colonic squamous cell carcinoma—a case report |
| title_short | Immunotherapy combined with chemotherapy: a promising therapeutic approach in the management of colonic squamous cell carcinoma—a case report |
| title_sort | immunotherapy combined with chemotherapy a promising therapeutic approach in the management of colonic squamous cell carcinoma a case report |
| topic | colorectal cancer squamous cell carcinoma anti-PD-1 therapy microsatellite instability case report |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1548008/full |
| work_keys_str_mv | AT bingbingren immunotherapycombinedwithchemotherapyapromisingtherapeuticapproachinthemanagementofcolonicsquamouscellcarcinomaacasereport AT haitaoyang immunotherapycombinedwithchemotherapyapromisingtherapeuticapproachinthemanagementofcolonicsquamouscellcarcinomaacasereport AT yingyingmao immunotherapycombinedwithchemotherapyapromisingtherapeuticapproachinthemanagementofcolonicsquamouscellcarcinomaacasereport |