Killer-Cell Immunoglobulin-Like Receptors (KIR) in HIV-Exposed Infants in Cameroon
The biological reason(s) behind persistent mother-to-child transmission (MTCT) of HIV (albeit at reduced rate compared to the preantiretroviral therapy era) in spite of the successful implementation of advanced control measures in many African countries remains a priority concern to many HIV/AIDS co...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2021/9053280 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832546999224762368 |
|---|---|
| author | Kagoué Simeni Luc-Aimé Yindom Louis-Marie Loni Ekali Gabriel Clauvis Kunkeng Yengo F. Esemu Livo Nguedia Jules Clement Assob |
| author_facet | Kagoué Simeni Luc-Aimé Yindom Louis-Marie Loni Ekali Gabriel Clauvis Kunkeng Yengo F. Esemu Livo Nguedia Jules Clement Assob |
| author_sort | Kagoué Simeni Luc-Aimé |
| collection | DOAJ |
| description | The biological reason(s) behind persistent mother-to-child transmission (MTCT) of HIV (albeit at reduced rate compared to the preantiretroviral therapy era) in spite of the successful implementation of advanced control measures in many African countries remains a priority concern to many HIV/AIDS control programs. This may be partly due to differences in host immunogenetic factors in highly polymorphic regions of the human genome such as those encoding the killer-cell immunoglobulin-like receptor (KIR) molecules which modulate the activities of natural killer cells. The primary aim of this study was to determine the variants of KIR genes that may have a role to play in MTCT in a cohort of infants born to HIV-infected mothers in Yaoundé, Cameroon. We designed a cross-sectional study to molecularly determine the frequencies of 15 KIR genes in 14 HIV-exposed infected (HEI), 39 HIV-exposed/uninfected (HEU), and 27 HIV-unexposed/uninfected (HUU) infants using the sequence specific primer polymerase chain reaction (PCR-SSP) method. We found that all 15 KIR genes were present in our cohort. The frequency of KIR2DL1 was significantly higher in the unexposed (control) group than in the HIV-exposed group (OR=0.22, P=0.006). Stratifying analysis by infection status but focusing only on exposed infants revealed that KIR2DL5, KIR2DS1, and KIR2DS5 were significantly overrepresented among the HIV-exposed/uninfected compared to infected infants (OR=0.20, P=0.006). Similarly, the frequencies of KIR2DS1, KIR2DS5, and KIR2DL5 were significantly different between infants perinatally infected with HIV (HIV+ by 6 months of age) and HIV-negative infants. Our study demonstrates that KIR genes may have differential effects with regard to MTCT of HIV-1. |
| format | Article |
| id | doaj-art-2eb3511d67d5406981cd7951f9559796 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-2eb3511d67d5406981cd7951f95597962025-02-03T06:46:14ZengWileyJournal of Immunology Research2314-88612314-71562021-01-01202110.1155/2021/90532809053280Killer-Cell Immunoglobulin-Like Receptors (KIR) in HIV-Exposed Infants in CameroonKagoué Simeni Luc-Aimé0Yindom Louis-Marie1Loni Ekali Gabriel2Clauvis Kunkeng Yengo3F. Esemu Livo4Nguedia Jules Clement Assob5Department of Medical Laboratory Sciences, Faculty of Health Sciences, University of Buea, Buea, CameroonNuffield Department of Medicine, University of Oxford, Oxford, UKNational Aids Control Committee, Yaoundé, CameroonDepartment of Biochemistry, Faculty of Sciences, University of Yaoundé I, Yaoundé, CameroonDepartment of Biochemistry, Faculty of Sciences, University of Yaoundé I, Yaoundé, CameroonDepartment of Medical Laboratory Sciences, Faculty of Health Sciences, University of Buea, Buea, CameroonThe biological reason(s) behind persistent mother-to-child transmission (MTCT) of HIV (albeit at reduced rate compared to the preantiretroviral therapy era) in spite of the successful implementation of advanced control measures in many African countries remains a priority concern to many HIV/AIDS control programs. This may be partly due to differences in host immunogenetic factors in highly polymorphic regions of the human genome such as those encoding the killer-cell immunoglobulin-like receptor (KIR) molecules which modulate the activities of natural killer cells. The primary aim of this study was to determine the variants of KIR genes that may have a role to play in MTCT in a cohort of infants born to HIV-infected mothers in Yaoundé, Cameroon. We designed a cross-sectional study to molecularly determine the frequencies of 15 KIR genes in 14 HIV-exposed infected (HEI), 39 HIV-exposed/uninfected (HEU), and 27 HIV-unexposed/uninfected (HUU) infants using the sequence specific primer polymerase chain reaction (PCR-SSP) method. We found that all 15 KIR genes were present in our cohort. The frequency of KIR2DL1 was significantly higher in the unexposed (control) group than in the HIV-exposed group (OR=0.22, P=0.006). Stratifying analysis by infection status but focusing only on exposed infants revealed that KIR2DL5, KIR2DS1, and KIR2DS5 were significantly overrepresented among the HIV-exposed/uninfected compared to infected infants (OR=0.20, P=0.006). Similarly, the frequencies of KIR2DS1, KIR2DS5, and KIR2DL5 were significantly different between infants perinatally infected with HIV (HIV+ by 6 months of age) and HIV-negative infants. Our study demonstrates that KIR genes may have differential effects with regard to MTCT of HIV-1.http://dx.doi.org/10.1155/2021/9053280 |
| spellingShingle | Kagoué Simeni Luc-Aimé Yindom Louis-Marie Loni Ekali Gabriel Clauvis Kunkeng Yengo F. Esemu Livo Nguedia Jules Clement Assob Killer-Cell Immunoglobulin-Like Receptors (KIR) in HIV-Exposed Infants in Cameroon Journal of Immunology Research |
| title | Killer-Cell Immunoglobulin-Like Receptors (KIR) in HIV-Exposed Infants in Cameroon |
| title_full | Killer-Cell Immunoglobulin-Like Receptors (KIR) in HIV-Exposed Infants in Cameroon |
| title_fullStr | Killer-Cell Immunoglobulin-Like Receptors (KIR) in HIV-Exposed Infants in Cameroon |
| title_full_unstemmed | Killer-Cell Immunoglobulin-Like Receptors (KIR) in HIV-Exposed Infants in Cameroon |
| title_short | Killer-Cell Immunoglobulin-Like Receptors (KIR) in HIV-Exposed Infants in Cameroon |
| title_sort | killer cell immunoglobulin like receptors kir in hiv exposed infants in cameroon |
| url | http://dx.doi.org/10.1155/2021/9053280 |
| work_keys_str_mv | AT kagouesimenilucaime killercellimmunoglobulinlikereceptorskirinhivexposedinfantsincameroon AT yindomlouismarie killercellimmunoglobulinlikereceptorskirinhivexposedinfantsincameroon AT loniekaligabriel killercellimmunoglobulinlikereceptorskirinhivexposedinfantsincameroon AT clauviskunkengyengo killercellimmunoglobulinlikereceptorskirinhivexposedinfantsincameroon AT fesemulivo killercellimmunoglobulinlikereceptorskirinhivexposedinfantsincameroon AT nguediajulesclementassob killercellimmunoglobulinlikereceptorskirinhivexposedinfantsincameroon |