Efficacy and Safety of Wilac L Probiotic Complex Isolated from Kimchi on the Regulation of Alcohol and Acetaldehyde Metabolism in Humans
Alcohol-related hangovers impact both physical and mental wellness, largely due to acetaldehyde levels produced through alcohol metabolism. The present study investigated the efficacy and safety of the Wilac L probiotic complex (<i>Levilactobacillus brevis</i> WiKim0168 and <i>Leuc...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-10-01
|
| Series: | Foods |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2304-8158/13/20/3285 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850205898058760192 |
|---|---|
| author | Hwayeon Sun Sangmin Park Jiye Mok Jeonghyun Seo Nicole Dain Lee Byungwook Yoo |
| author_facet | Hwayeon Sun Sangmin Park Jiye Mok Jeonghyun Seo Nicole Dain Lee Byungwook Yoo |
| author_sort | Hwayeon Sun |
| collection | DOAJ |
| description | Alcohol-related hangovers impact both physical and mental wellness, largely due to acetaldehyde levels produced through alcohol metabolism. The present study investigated the efficacy and safety of the Wilac L probiotic complex (<i>Levilactobacillus brevis</i> WiKim0168 and <i>Leuconostoc mesenteroides</i> WiKim0172 isolated from kimchi) in improving hangovers post-alcohol consumption. This study was conducted as a randomized, double-blind, crossover placebo-controlled clinical trial from August 2023 to February 2024. Subjects (<i>n</i> = 26) were randomized into six test groups consuming three products, the Wilac L probiotic complex, Wilac L35 (Wilac L probiotic complex with <i>Pyrus pyrifolia</i> Nakai), or placebo, in different orders with crossover after a wash-out interval of 7–10 days. Blood alcohol and acetaldehyde concentrations were measured 0, 0.25, 0.5, 1, 2, 4, 6, and 15 h after alcohol consumption. The blood acetaldehyde levels measured with Wilac L probiotic complex supplementation were significantly lower than the control at 0.25 (<i>p</i> = 0.0381), 0.5 (<i>p</i> = 0.0498), and 1 h (<i>p</i> = 0.0260) post-consumption. The blood acetaldehyde levels after Wilac L35 consumption compared to the control are significant at 0.25 (<i>p</i> = 0.0115), 0.5 (<i>p</i> = 0.0054), 1 (<i>p</i> = 0.0285), 2 (<i>p</i> = 0.0113), and 6 h (<i>p</i> = 0.0287) post-consumption. No significant adverse events were reported. The Wilac L probiotic complex is associated with decreased blood acetaldehyde levels and improved subjective hangover symptoms. |
| format | Article |
| id | doaj-art-2eb04572f0e740ecb84c425d191ab9cb |
| institution | OA Journals |
| issn | 2304-8158 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj-art-2eb04572f0e740ecb84c425d191ab9cb2025-08-20T02:11:00ZengMDPI AGFoods2304-81582024-10-011320328510.3390/foods13203285Efficacy and Safety of Wilac L Probiotic Complex Isolated from Kimchi on the Regulation of Alcohol and Acetaldehyde Metabolism in HumansHwayeon Sun0Sangmin Park1Jiye Mok2Jeonghyun Seo3Nicole Dain Lee4Byungwook Yoo5Microbiome R&D Center, Pharmsville, Co., Ltd., Seoul 07793, Republic of KoreaMicrobiome R&D Center, Pharmsville, Co., Ltd., Seoul 07793, Republic of KoreaMicrobiome R&D Center, Pharmsville, Co., Ltd., Seoul 07793, Republic of KoreaMicrobiome R&D Center, Pharmsville, Co., Ltd., Seoul 07793, Republic of KoreaSchool of Medicine, Georgetown University, Washington, DC 20007, USADepartment of Family Medicine, Soonchunhyang University Seoul Hospital, Seoul 04401, Republic of KoreaAlcohol-related hangovers impact both physical and mental wellness, largely due to acetaldehyde levels produced through alcohol metabolism. The present study investigated the efficacy and safety of the Wilac L probiotic complex (<i>Levilactobacillus brevis</i> WiKim0168 and <i>Leuconostoc mesenteroides</i> WiKim0172 isolated from kimchi) in improving hangovers post-alcohol consumption. This study was conducted as a randomized, double-blind, crossover placebo-controlled clinical trial from August 2023 to February 2024. Subjects (<i>n</i> = 26) were randomized into six test groups consuming three products, the Wilac L probiotic complex, Wilac L35 (Wilac L probiotic complex with <i>Pyrus pyrifolia</i> Nakai), or placebo, in different orders with crossover after a wash-out interval of 7–10 days. Blood alcohol and acetaldehyde concentrations were measured 0, 0.25, 0.5, 1, 2, 4, 6, and 15 h after alcohol consumption. The blood acetaldehyde levels measured with Wilac L probiotic complex supplementation were significantly lower than the control at 0.25 (<i>p</i> = 0.0381), 0.5 (<i>p</i> = 0.0498), and 1 h (<i>p</i> = 0.0260) post-consumption. The blood acetaldehyde levels after Wilac L35 consumption compared to the control are significant at 0.25 (<i>p</i> = 0.0115), 0.5 (<i>p</i> = 0.0054), 1 (<i>p</i> = 0.0285), 2 (<i>p</i> = 0.0113), and 6 h (<i>p</i> = 0.0287) post-consumption. No significant adverse events were reported. The Wilac L probiotic complex is associated with decreased blood acetaldehyde levels and improved subjective hangover symptoms.https://www.mdpi.com/2304-8158/13/20/3285alcohol metabolismacetaldehydealcoholhangover relief |
| spellingShingle | Hwayeon Sun Sangmin Park Jiye Mok Jeonghyun Seo Nicole Dain Lee Byungwook Yoo Efficacy and Safety of Wilac L Probiotic Complex Isolated from Kimchi on the Regulation of Alcohol and Acetaldehyde Metabolism in Humans Foods alcohol metabolism acetaldehyde alcohol hangover relief |
| title | Efficacy and Safety of Wilac L Probiotic Complex Isolated from Kimchi on the Regulation of Alcohol and Acetaldehyde Metabolism in Humans |
| title_full | Efficacy and Safety of Wilac L Probiotic Complex Isolated from Kimchi on the Regulation of Alcohol and Acetaldehyde Metabolism in Humans |
| title_fullStr | Efficacy and Safety of Wilac L Probiotic Complex Isolated from Kimchi on the Regulation of Alcohol and Acetaldehyde Metabolism in Humans |
| title_full_unstemmed | Efficacy and Safety of Wilac L Probiotic Complex Isolated from Kimchi on the Regulation of Alcohol and Acetaldehyde Metabolism in Humans |
| title_short | Efficacy and Safety of Wilac L Probiotic Complex Isolated from Kimchi on the Regulation of Alcohol and Acetaldehyde Metabolism in Humans |
| title_sort | efficacy and safety of wilac l probiotic complex isolated from kimchi on the regulation of alcohol and acetaldehyde metabolism in humans |
| topic | alcohol metabolism acetaldehyde alcohol hangover relief |
| url | https://www.mdpi.com/2304-8158/13/20/3285 |
| work_keys_str_mv | AT hwayeonsun efficacyandsafetyofwilaclprobioticcomplexisolatedfromkimchiontheregulationofalcoholandacetaldehydemetabolisminhumans AT sangminpark efficacyandsafetyofwilaclprobioticcomplexisolatedfromkimchiontheregulationofalcoholandacetaldehydemetabolisminhumans AT jiyemok efficacyandsafetyofwilaclprobioticcomplexisolatedfromkimchiontheregulationofalcoholandacetaldehydemetabolisminhumans AT jeonghyunseo efficacyandsafetyofwilaclprobioticcomplexisolatedfromkimchiontheregulationofalcoholandacetaldehydemetabolisminhumans AT nicoledainlee efficacyandsafetyofwilaclprobioticcomplexisolatedfromkimchiontheregulationofalcoholandacetaldehydemetabolisminhumans AT byungwookyoo efficacyandsafetyofwilaclprobioticcomplexisolatedfromkimchiontheregulationofalcoholandacetaldehydemetabolisminhumans |