Are Selective Serotonin Reuptake Inhibitors a Secondary Cause of Low Bone Density?
Background. Osteoporosis is a chronic disease that can significantly impact numerous aspects of health and wellness. The individual consequences of osteoporosis can be devastating, often resulting in substantial loss of independence and sometimes death. One of the few illnesses with greater disease...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Osteoporosis |
| Online Access: | http://dx.doi.org/10.1155/2012/323061 |
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| _version_ | 1832561058285355008 |
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| author | Kim Chau Stephanie A. Atkinson Valerie H. Taylor |
| author_facet | Kim Chau Stephanie A. Atkinson Valerie H. Taylor |
| author_sort | Kim Chau |
| collection | DOAJ |
| description | Background. Osteoporosis is a chronic disease that can significantly impact numerous aspects of health and wellness. The individual consequences of osteoporosis can be devastating, often resulting in substantial loss of independence and sometimes death. One of the few illnesses with greater disease burden than low bone mineral density (BMD) is major depressive disorder (MDD). Both depression and antidepressant use have been identified as secondary causes of osteoporosis. The objective of this paper is to review and summarize the current findings on the relationship between antidepressant use and BMD. Methods. Relevant sources were identified from the Pubmed and MEDLINE databases, citing articles from the first relevant publication to September 1st, 2010. Results. 2001 articles initially met the search criteria, and 35 studies were thoroughly reviewed for evidence of an association between SSRI use and BMD, and 8 clinical studies were detailed and summarized in this paper. Conclusions. Current findings suggest a link between mental illness and osteoporosis that is of clinical relevance. Additional longitudinal studies and further research on possible mechanisms surrounding the association between SSRI use on bone metabolism need to be conducted. Treatment algorithms need to recognize this association to ensure that vulnerable populations are screened. |
| format | Article |
| id | doaj-art-2eae6fc2b5274a1c8ab3474d507ac98c |
| institution | Kabale University |
| issn | 2090-8059 2042-0064 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Osteoporosis |
| spelling | doaj-art-2eae6fc2b5274a1c8ab3474d507ac98c2025-02-03T01:26:02ZengWileyJournal of Osteoporosis2090-80592042-00642012-01-01201210.1155/2012/323061323061Are Selective Serotonin Reuptake Inhibitors a Secondary Cause of Low Bone Density?Kim Chau0Stephanie A. Atkinson1Valerie H. Taylor2Department of Paediatrics, McMaster University, Hamilton, ON, L8S 4L8, CanadaDepartment of Paediatrics, McMaster University, Hamilton, ON, L8S 4L8, CanadaDepartment of Psychiatry, University of Toronto, Toronto, ON, L8S 4L8, CanadaBackground. Osteoporosis is a chronic disease that can significantly impact numerous aspects of health and wellness. The individual consequences of osteoporosis can be devastating, often resulting in substantial loss of independence and sometimes death. One of the few illnesses with greater disease burden than low bone mineral density (BMD) is major depressive disorder (MDD). Both depression and antidepressant use have been identified as secondary causes of osteoporosis. The objective of this paper is to review and summarize the current findings on the relationship between antidepressant use and BMD. Methods. Relevant sources were identified from the Pubmed and MEDLINE databases, citing articles from the first relevant publication to September 1st, 2010. Results. 2001 articles initially met the search criteria, and 35 studies were thoroughly reviewed for evidence of an association between SSRI use and BMD, and 8 clinical studies were detailed and summarized in this paper. Conclusions. Current findings suggest a link between mental illness and osteoporosis that is of clinical relevance. Additional longitudinal studies and further research on possible mechanisms surrounding the association between SSRI use on bone metabolism need to be conducted. Treatment algorithms need to recognize this association to ensure that vulnerable populations are screened.http://dx.doi.org/10.1155/2012/323061 |
| spellingShingle | Kim Chau Stephanie A. Atkinson Valerie H. Taylor Are Selective Serotonin Reuptake Inhibitors a Secondary Cause of Low Bone Density? Journal of Osteoporosis |
| title | Are Selective Serotonin Reuptake Inhibitors a Secondary Cause of Low Bone Density? |
| title_full | Are Selective Serotonin Reuptake Inhibitors a Secondary Cause of Low Bone Density? |
| title_fullStr | Are Selective Serotonin Reuptake Inhibitors a Secondary Cause of Low Bone Density? |
| title_full_unstemmed | Are Selective Serotonin Reuptake Inhibitors a Secondary Cause of Low Bone Density? |
| title_short | Are Selective Serotonin Reuptake Inhibitors a Secondary Cause of Low Bone Density? |
| title_sort | are selective serotonin reuptake inhibitors a secondary cause of low bone density |
| url | http://dx.doi.org/10.1155/2012/323061 |
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