Adverse Events and Satisfaction Outcomes with Calcium Hydroxylapatite and Polycaprolactone Fillers in Facial Aesthetics: A Systematic Review
Objective: The aim of this study was to systematically review the safety and effectiveness of the injectable biostimulators dermal fillers calcium hydroxyapatite (CaHA) and polycaprolactone (PCL) in facial esthetic procedures. Materials and Methods: Comprehensive electronic searches were executed ac...
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MDPI AG
2024-09-01
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| Series: | Cosmetics |
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| author | Rafael Zago Sá Fortes Juliana Cassol Spanemberg Karen Cherubini Fernanda Gonçalves Salum |
| author_facet | Rafael Zago Sá Fortes Juliana Cassol Spanemberg Karen Cherubini Fernanda Gonçalves Salum |
| author_sort | Rafael Zago Sá Fortes |
| collection | DOAJ |
| description | Objective: The aim of this study was to systematically review the safety and effectiveness of the injectable biostimulators dermal fillers calcium hydroxyapatite (CaHA) and polycaprolactone (PCL) in facial esthetic procedures. Materials and Methods: Comprehensive electronic searches were executed across six academic databases. The primary outcome focused on safety by examining studies that reported the incidence of adverse events (AEs). The secondary outcome gauged the satisfaction of the patients and injectors by validated esthetic scales. To evaluate biases, the Joanna Briggs Institute Checklist tools were employed. Results: We included a total of 79 studies. In the quantitative assessment of the CaHA, out of 5032 injected patients, 21.8% manifested early AEs, 0.85% experienced delayed reactions, and 0.27% had severe complications. Within the PCL group, consisting of 1119 patients, 83.3% exhibited early AEs, 5.6% had delayed reactions, and none had serious complications. Regarding esthetic satisfaction outcome, both products presented favorable results, but a limited number of studies assessed these data. In the studies evaluated qualitatively, a broad array of AEs were cataloged. Conclusions: The occurrence of serious AEs associated with CaHA and PCL fillers is relatively low. Both CaHA and PCL fillers exhibit favorable safety profiles, with most AEs being transient in nature. |
| format | Article |
| id | doaj-art-2eadbd3347024e4aab7ff658c9568816 |
| institution | OA Journals |
| issn | 2079-9284 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cosmetics |
| spelling | doaj-art-2eadbd3347024e4aab7ff658c95688162025-08-20T02:11:12ZengMDPI AGCosmetics2079-92842024-09-0111516510.3390/cosmetics11050165Adverse Events and Satisfaction Outcomes with Calcium Hydroxylapatite and Polycaprolactone Fillers in Facial Aesthetics: A Systematic ReviewRafael Zago Sá Fortes0Juliana Cassol Spanemberg1Karen Cherubini2Fernanda Gonçalves Salum3School of Health and Life Sciences, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre 90610-000, Rio Grande do Sul, BrazilOral Medicine and Phototherapy Research Group—OMEP, Santa María de Guía, Faculty of Health Sciences, Department of Dentistry, Fernando Pessoa Canarias University (UFPC), 35450 Las Palmas, SpainSchool of Health and Life Sciences, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre 90610-000, Rio Grande do Sul, BrazilSchool of Health and Life Sciences, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre 90610-000, Rio Grande do Sul, BrazilObjective: The aim of this study was to systematically review the safety and effectiveness of the injectable biostimulators dermal fillers calcium hydroxyapatite (CaHA) and polycaprolactone (PCL) in facial esthetic procedures. Materials and Methods: Comprehensive electronic searches were executed across six academic databases. The primary outcome focused on safety by examining studies that reported the incidence of adverse events (AEs). The secondary outcome gauged the satisfaction of the patients and injectors by validated esthetic scales. To evaluate biases, the Joanna Briggs Institute Checklist tools were employed. Results: We included a total of 79 studies. In the quantitative assessment of the CaHA, out of 5032 injected patients, 21.8% manifested early AEs, 0.85% experienced delayed reactions, and 0.27% had severe complications. Within the PCL group, consisting of 1119 patients, 83.3% exhibited early AEs, 5.6% had delayed reactions, and none had serious complications. Regarding esthetic satisfaction outcome, both products presented favorable results, but a limited number of studies assessed these data. In the studies evaluated qualitatively, a broad array of AEs were cataloged. Conclusions: The occurrence of serious AEs associated with CaHA and PCL fillers is relatively low. Both CaHA and PCL fillers exhibit favorable safety profiles, with most AEs being transient in nature.https://www.mdpi.com/2079-9284/11/5/165biocompatible materialsdermal fillersforeign body reactioncalcium hydroxilapatitepolycaprolactone |
| spellingShingle | Rafael Zago Sá Fortes Juliana Cassol Spanemberg Karen Cherubini Fernanda Gonçalves Salum Adverse Events and Satisfaction Outcomes with Calcium Hydroxylapatite and Polycaprolactone Fillers in Facial Aesthetics: A Systematic Review Cosmetics biocompatible materials dermal fillers foreign body reaction calcium hydroxilapatite polycaprolactone |
| title | Adverse Events and Satisfaction Outcomes with Calcium Hydroxylapatite and Polycaprolactone Fillers in Facial Aesthetics: A Systematic Review |
| title_full | Adverse Events and Satisfaction Outcomes with Calcium Hydroxylapatite and Polycaprolactone Fillers in Facial Aesthetics: A Systematic Review |
| title_fullStr | Adverse Events and Satisfaction Outcomes with Calcium Hydroxylapatite and Polycaprolactone Fillers in Facial Aesthetics: A Systematic Review |
| title_full_unstemmed | Adverse Events and Satisfaction Outcomes with Calcium Hydroxylapatite and Polycaprolactone Fillers in Facial Aesthetics: A Systematic Review |
| title_short | Adverse Events and Satisfaction Outcomes with Calcium Hydroxylapatite and Polycaprolactone Fillers in Facial Aesthetics: A Systematic Review |
| title_sort | adverse events and satisfaction outcomes with calcium hydroxylapatite and polycaprolactone fillers in facial aesthetics a systematic review |
| topic | biocompatible materials dermal fillers foreign body reaction calcium hydroxilapatite polycaprolactone |
| url | https://www.mdpi.com/2079-9284/11/5/165 |
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