Changing paradigms for the micronutrient zinc, a known protein cofactor, as a signal relaying also cellular redox state
The micronutrient zinc (Zn) is often poorly available but toxic when present in excess, so a tightly controlled Zn homoeostasis network operates in all organisms. This review summarizes our present understanding of plant Zn homoeostasis. In Arabidopsis, about 1,900 Zn-binding metalloproteins require...
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Cambridge University Press
2025-01-01
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| Series: | Quantitative Plant Biology |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S2632882825000049/type/journal_article |
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| author | Ute Krämer |
| author_facet | Ute Krämer |
| author_sort | Ute Krämer |
| collection | DOAJ |
| description | The micronutrient zinc (Zn) is often poorly available but toxic when present in excess, so a tightly controlled Zn homoeostasis network operates in all organisms. This review summarizes our present understanding of plant Zn homoeostasis. In Arabidopsis, about 1,900 Zn-binding metalloproteins require Zn as a cofactor. Abundant Zn metalloproteins reside in plastids, mitochondria and peroxisomes, emphasizing the need to address how Zn reaches these proteins. Apo–Zn metalloproteins do not acquire Zn2+ from a cytosolic pool of free cations, but instead through associative ligand exchange from Zn-buffering molecules. The importance of cytosolic thiols in Zn buffering suggests that, besides elevated Zn influx, a more oxidized redox state is also predicted to cause elevated labile-bound Zn levels, consistent with the suppression of a Zn deficiency marker under oxidative stress. Therefore, we consider a broadened physiological scope in plants for a possible signalling role of Zn2+, experimentally supported only in animals to date. |
| format | Article |
| id | doaj-art-2ead83da5fd44eb8906bb1e813635c7a |
| institution | OA Journals |
| issn | 2632-8828 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Quantitative Plant Biology |
| spelling | doaj-art-2ead83da5fd44eb8906bb1e813635c7a2025-08-20T02:20:19ZengCambridge University PressQuantitative Plant Biology2632-88282025-01-01610.1017/qpb.2025.4Changing paradigms for the micronutrient zinc, a known protein cofactor, as a signal relaying also cellular redox stateUte Krämer0https://orcid.org/0000-0001-7870-4508Molecular Genetics and Physiology of Plants, Ruhr University Bochum, Bochum, GermanyThe micronutrient zinc (Zn) is often poorly available but toxic when present in excess, so a tightly controlled Zn homoeostasis network operates in all organisms. This review summarizes our present understanding of plant Zn homoeostasis. In Arabidopsis, about 1,900 Zn-binding metalloproteins require Zn as a cofactor. Abundant Zn metalloproteins reside in plastids, mitochondria and peroxisomes, emphasizing the need to address how Zn reaches these proteins. Apo–Zn metalloproteins do not acquire Zn2+ from a cytosolic pool of free cations, but instead through associative ligand exchange from Zn-buffering molecules. The importance of cytosolic thiols in Zn buffering suggests that, besides elevated Zn influx, a more oxidized redox state is also predicted to cause elevated labile-bound Zn levels, consistent with the suppression of a Zn deficiency marker under oxidative stress. Therefore, we consider a broadened physiological scope in plants for a possible signalling role of Zn2+, experimentally supported only in animals to date.https://www.cambridge.org/core/product/identifier/S2632882825000049/type/journal_articleplant nutritionmetalloproteinmetal homeostasiszinc sensorzinc transporter |
| spellingShingle | Ute Krämer Changing paradigms for the micronutrient zinc, a known protein cofactor, as a signal relaying also cellular redox state Quantitative Plant Biology plant nutrition metalloprotein metal homeostasis zinc sensor zinc transporter |
| title | Changing paradigms for the micronutrient zinc, a known protein cofactor, as a signal relaying also cellular redox state |
| title_full | Changing paradigms for the micronutrient zinc, a known protein cofactor, as a signal relaying also cellular redox state |
| title_fullStr | Changing paradigms for the micronutrient zinc, a known protein cofactor, as a signal relaying also cellular redox state |
| title_full_unstemmed | Changing paradigms for the micronutrient zinc, a known protein cofactor, as a signal relaying also cellular redox state |
| title_short | Changing paradigms for the micronutrient zinc, a known protein cofactor, as a signal relaying also cellular redox state |
| title_sort | changing paradigms for the micronutrient zinc a known protein cofactor as a signal relaying also cellular redox state |
| topic | plant nutrition metalloprotein metal homeostasis zinc sensor zinc transporter |
| url | https://www.cambridge.org/core/product/identifier/S2632882825000049/type/journal_article |
| work_keys_str_mv | AT utekramer changingparadigmsforthemicronutrientzincaknownproteincofactorasasignalrelayingalsocellularredoxstate |