Nanoformulation innovations: Revolutionizing precision in migraine therapy
Objective(s): Migraine, a serious neurological disease that affects millions of people worldwide, is one of the most considerable burdens on the healthcare system and has significant economic implications. Even though various treatment methods are available, including medication, lifestyle changes,...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2025-01-01
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| Series: | Iranian Journal of Basic Medical Sciences |
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| Online Access: | https://ijbms.mums.ac.ir/article_24973_45bcb4158416a7d1a8d4db23ad53a342.pdf |
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| author | Mohammad Ghasemi Farimani Fatemeh Kalalinia Somayeh Marouzi Sara Gheshlaghi Zahra Salmasi Maryam Hashemi |
| author_facet | Mohammad Ghasemi Farimani Fatemeh Kalalinia Somayeh Marouzi Sara Gheshlaghi Zahra Salmasi Maryam Hashemi |
| author_sort | Mohammad Ghasemi Farimani |
| collection | DOAJ |
| description | Objective(s): Migraine, a serious neurological disease that affects millions of people worldwide, is one of the most considerable burdens on the healthcare system and has significant economic implications. Even though various treatment methods are available, including medication, lifestyle changes, and behavioral therapy, many migraine sufferers do not receive adequate relief or experience intolerable side effects. Hence, the present review aims to evaluate the nanoformulation regarding migraine therapy.Materials and Methods: Between 2005 and 2024, specific keywords were used to search several databases, such as Pubmed, Google Scholar, and Scopus. Results: The nanoformulation field is an increasing field within nanotechnology that offers new solutions for treating migraine, including improving drug delivery, increasing therapeutic efficacy, and minimizing side effects. By combining nanoscale materials with therapeutic agents, nanoformulations can enhance bioavailability, sustain drug release, deliver targeted drugs, and penetrate the Blood-Brain Barrier (BBB) more efficiently. Nanoformulation has the potential to be a useful tool for migraine therapy. However, several challenges still need to be overcome, such as the BBB penetration, safety and biocompatibility of the product, manufacturing, and scalability reproducibility to pass regulatory approval and affordability. To overcome these challenges, research efforts should be focused on developing innovative techniques to penetrate the BBB, target specific migraine pathways, incorporate personalized medicine approaches, and develop nanotechnology-based diagnostics.Conclusion: A nanotechnology-based approach aims to revolutionize migraine therapy, improving patient outcomes and living standards by offering personalized and precise treatments. |
| format | Article |
| id | doaj-art-2ea45d9d6ece490295cda17783890362 |
| institution | DOAJ |
| issn | 2008-3866 2008-3874 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj-art-2ea45d9d6ece490295cda177838903622025-08-20T02:48:06ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742025-01-01281163010.22038/ijbms.2024.79824.1729024973Nanoformulation innovations: Revolutionizing precision in migraine therapyMohammad Ghasemi Farimani0Fatemeh Kalalinia1Somayeh Marouzi2Sara Gheshlaghi3Zahra Salmasi4Maryam Hashemi5School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranBiotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, IranDepartments of Pharmaceutical Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranSchool of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranNanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, IranDepartments of Pharmaceutical Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranObjective(s): Migraine, a serious neurological disease that affects millions of people worldwide, is one of the most considerable burdens on the healthcare system and has significant economic implications. Even though various treatment methods are available, including medication, lifestyle changes, and behavioral therapy, many migraine sufferers do not receive adequate relief or experience intolerable side effects. Hence, the present review aims to evaluate the nanoformulation regarding migraine therapy.Materials and Methods: Between 2005 and 2024, specific keywords were used to search several databases, such as Pubmed, Google Scholar, and Scopus. Results: The nanoformulation field is an increasing field within nanotechnology that offers new solutions for treating migraine, including improving drug delivery, increasing therapeutic efficacy, and minimizing side effects. By combining nanoscale materials with therapeutic agents, nanoformulations can enhance bioavailability, sustain drug release, deliver targeted drugs, and penetrate the Blood-Brain Barrier (BBB) more efficiently. Nanoformulation has the potential to be a useful tool for migraine therapy. However, several challenges still need to be overcome, such as the BBB penetration, safety and biocompatibility of the product, manufacturing, and scalability reproducibility to pass regulatory approval and affordability. To overcome these challenges, research efforts should be focused on developing innovative techniques to penetrate the BBB, target specific migraine pathways, incorporate personalized medicine approaches, and develop nanotechnology-based diagnostics.Conclusion: A nanotechnology-based approach aims to revolutionize migraine therapy, improving patient outcomes and living standards by offering personalized and precise treatments.https://ijbms.mums.ac.ir/article_24973_45bcb4158416a7d1a8d4db23ad53a342.pdfdrug deliverymigrainenanocapsulesnanoformulationnanoparticlesnanotechnology |
| spellingShingle | Mohammad Ghasemi Farimani Fatemeh Kalalinia Somayeh Marouzi Sara Gheshlaghi Zahra Salmasi Maryam Hashemi Nanoformulation innovations: Revolutionizing precision in migraine therapy Iranian Journal of Basic Medical Sciences drug delivery migraine nanocapsules nanoformulation nanoparticles nanotechnology |
| title | Nanoformulation innovations: Revolutionizing precision in migraine therapy |
| title_full | Nanoformulation innovations: Revolutionizing precision in migraine therapy |
| title_fullStr | Nanoformulation innovations: Revolutionizing precision in migraine therapy |
| title_full_unstemmed | Nanoformulation innovations: Revolutionizing precision in migraine therapy |
| title_short | Nanoformulation innovations: Revolutionizing precision in migraine therapy |
| title_sort | nanoformulation innovations revolutionizing precision in migraine therapy |
| topic | drug delivery migraine nanocapsules nanoformulation nanoparticles nanotechnology |
| url | https://ijbms.mums.ac.ir/article_24973_45bcb4158416a7d1a8d4db23ad53a342.pdf |
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