CCL2 produced by pancreatic ductal adenocarcinoma is essential for the accumulation and activation of monocytic myeloid‐derived suppressor cells

CCL2 produced by pancreatic ductal adenocarcinoma is essential for the accumulation and activation of monocytic myeloid‐derived suppressor cells

Abstract Introduction The development of pancreatic ductal adenocarcinoma (PDAC) is closely tied with the immune system. C‐C motif chemokine ligands (CCL) were proved to lead to immune recruitment and training. Thus, we reckoned CCL2 to be the kernel of immune suppression in PDAC tissues. Methods We...

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Bibliographic Details
Main Authors: Haitao Gu, Wensheng Deng, Zhong Zheng, Ke Wu, Feng Sun
Format: Article
Language:English
Published: Wiley 2021-12-01
Series:Immunity, Inflammation and Disease
Subjects:
CCL2
immune suppression
M‐MDSCs
pancreatic ductal adenocarcinoma
Online Access:https://doi.org/10.1002/iid3.523
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