Association between Hepatitis B virus infection and COVID-19: outcomes from clinical analysis and online survey from Beijing, China
Abstract Objective We aim to investigate whether Coronavirus disease 2019 (COVID-19) worsens chronic hepatitis B virus(HBV)infection and explore the incidence of long COVID symptoms in patients with chronic hepatitis B virus infection. Methods Patients with chronic HBV infection and COVID-19 patient...
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2024-12-01
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| Online Access: | https://doi.org/10.1186/s12879-024-10333-z |
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| author | Fei Lin Sihan Hao Xiumei Xiao Xiaoguang Li |
| author_facet | Fei Lin Sihan Hao Xiumei Xiao Xiaoguang Li |
| author_sort | Fei Lin |
| collection | DOAJ |
| description | Abstract Objective We aim to investigate whether Coronavirus disease 2019 (COVID-19) worsens chronic hepatitis B virus(HBV)infection and explore the incidence of long COVID symptoms in patients with chronic hepatitis B virus infection. Methods Patients with chronic HBV infection and COVID-19 patients attending the hepatitis clinic or fever clinic were included in the study. Clinical manifestations of COVID-19 and information about long COVID were collected for all patients. For patients with chronic hepatitis B virus infection, laboratory test results such as HBV-DNA, liver function, and kidney function were collected three months before and after COVID-19. Results A total of 940 patients with COVID-19 were included in this study. These patients were divided into two groups: the hepatitis B virus infection group with 189 patients and the non-hepatitis B group with 751 patients. Further matching analysis was conducted, selecting 156 patients from each group. Within the hepatitis B group, patients were further divided into two subgroups based on whether they received antiviral therapy: 90 patients in the antiviral therapy group and 99 patients in the non-antiviral therapy group. Neither group experienced a significant increase in HBV-DNA after COVID-19. There were significant differences between the two groups regarding BMI and symptoms of sore throat, loss of smell, and nasal congestion during COVID-19. The incidence of long COVID symptoms was higher in the hepatitis B group compared to the non-hepatitis B group (64.1% vs. 48.7%, p < 0.001), with the top five symptoms being cough, fatigue, palpitations, insomnia, and memory impairment. Conclusion Patients with chronic HBV infection did not show a significant rise in HBV DNA after COVID-19 in this study. They had a lower incidence of COVID-19 symptoms but experienced a higher incidence of long COVID symptoms. |
| format | Article |
| id | doaj-art-2e9aca0dce7e4de182ff34838ae228ee |
| institution | OA Journals |
| issn | 1471-2334 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj-art-2e9aca0dce7e4de182ff34838ae228ee2025-08-20T02:31:38ZengBMCBMC Infectious Diseases1471-23342024-12-012411910.1186/s12879-024-10333-zAssociation between Hepatitis B virus infection and COVID-19: outcomes from clinical analysis and online survey from Beijing, ChinaFei Lin0Sihan Hao1Xiumei Xiao2Xiaoguang Li3Department of Infectious Diseases, Peking University Third HospitalThe David C. Frederick Honors College, University of PittsburghDepartment of Laboratory Medicine, Peking University Third HospitalDepartment of Infectious Diseases, Peking University Third HospitalAbstract Objective We aim to investigate whether Coronavirus disease 2019 (COVID-19) worsens chronic hepatitis B virus(HBV)infection and explore the incidence of long COVID symptoms in patients with chronic hepatitis B virus infection. Methods Patients with chronic HBV infection and COVID-19 patients attending the hepatitis clinic or fever clinic were included in the study. Clinical manifestations of COVID-19 and information about long COVID were collected for all patients. For patients with chronic hepatitis B virus infection, laboratory test results such as HBV-DNA, liver function, and kidney function were collected three months before and after COVID-19. Results A total of 940 patients with COVID-19 were included in this study. These patients were divided into two groups: the hepatitis B virus infection group with 189 patients and the non-hepatitis B group with 751 patients. Further matching analysis was conducted, selecting 156 patients from each group. Within the hepatitis B group, patients were further divided into two subgroups based on whether they received antiviral therapy: 90 patients in the antiviral therapy group and 99 patients in the non-antiviral therapy group. Neither group experienced a significant increase in HBV-DNA after COVID-19. There were significant differences between the two groups regarding BMI and symptoms of sore throat, loss of smell, and nasal congestion during COVID-19. The incidence of long COVID symptoms was higher in the hepatitis B group compared to the non-hepatitis B group (64.1% vs. 48.7%, p < 0.001), with the top five symptoms being cough, fatigue, palpitations, insomnia, and memory impairment. Conclusion Patients with chronic HBV infection did not show a significant rise in HBV DNA after COVID-19 in this study. They had a lower incidence of COVID-19 symptoms but experienced a higher incidence of long COVID symptoms.https://doi.org/10.1186/s12879-024-10333-zHepatitis B virusCOVID-19HBV-DNALong COVID |
| spellingShingle | Fei Lin Sihan Hao Xiumei Xiao Xiaoguang Li Association between Hepatitis B virus infection and COVID-19: outcomes from clinical analysis and online survey from Beijing, China BMC Infectious Diseases Hepatitis B virus COVID-19 HBV-DNA Long COVID |
| title | Association between Hepatitis B virus infection and COVID-19: outcomes from clinical analysis and online survey from Beijing, China |
| title_full | Association between Hepatitis B virus infection and COVID-19: outcomes from clinical analysis and online survey from Beijing, China |
| title_fullStr | Association between Hepatitis B virus infection and COVID-19: outcomes from clinical analysis and online survey from Beijing, China |
| title_full_unstemmed | Association between Hepatitis B virus infection and COVID-19: outcomes from clinical analysis and online survey from Beijing, China |
| title_short | Association between Hepatitis B virus infection and COVID-19: outcomes from clinical analysis and online survey from Beijing, China |
| title_sort | association between hepatitis b virus infection and covid 19 outcomes from clinical analysis and online survey from beijing china |
| topic | Hepatitis B virus COVID-19 HBV-DNA Long COVID |
| url | https://doi.org/10.1186/s12879-024-10333-z |
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