A MIV-150/zinc acetate gel inhibits SHIV-RT infection in macaque vaginal explants.

A MIV-150/zinc acetate gel inhibits SHIV-RT infection in macaque vaginal explants.

To extend our observations that single or repeated application of a gel containing the NNRTI MIV-150 (M) and zinc acetate dihydrate (ZA) in carrageenan (CG) (MZC) inhibits vaginal transmission of simian/human immunodeficiency virus (SHIV)-RT in macaques, we evaluated safety and anti-SHIV-RT activity...

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Main Authors: Patrick Barnable, Giulia Calenda, Louise Ouattara, Agegnehu Gettie, James Blanchard, Ninochka Jean-Pierre, Larisa Kizima, Aixa Rodríguez, Ciby Abraham, Radhika Menon, Samantha Seidor, Michael L Cooney, Kevin D Roberts, Rhoda Sperling, Michael Piatak, Jeffrey D Lifson, Jose A Fernandez-Romero, Thomas M Zydowsky, Melissa Robbiani, Natalia Teleshova
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0108109&type=printable
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