Dual-Network QSAZ@VPH hydrogel-mediated verapamil treatment improved recovery of diabetic ulcer through inhibiting mitochondrial oxidative stress and enhancing angiogenesis

Dual-Network QSAZ@VPH hydrogel-mediated verapamil treatment improved recovery of diabetic ulcer through inhibiting mitochondrial oxidative stress and enhancing angiogenesis

Background: Diabetic ulcer (DU) are severe complications of diabetes, characterized by persistent inflammation, oxidative stress, and impaired mitochondrial function. Verapamil, a calcium channel blocker, has shown potential in reducing oxidative stress and improving mitochondrial dysfunction, but i...

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Main Authors: Bin Chen, Hang Li, Yuliang Sun, Yuhua Li, Parisa Anvari, Ghazal Shokraneh, Menglin Cong, AmirMahdi Saeidi, Hecheng Ma, Tian Li, Gang Wang, Junhao Lin, Zhijian Wei
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Materials & Design
Subjects:
Diabetic ulcers
Verapamil
Hydrogel delivery
Wound healing
Mitochondrial
Online Access:http://www.sciencedirect.com/science/article/pii/S0264127525006720
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