Preliminary Evaluation of HSA and DNA Interactions with Indole-Thiosemicarbazone Compounds and Molecular Docking Studies

Preliminary Evaluation of HSA and DNA Interactions with Indole-Thiosemicarbazone Compounds and Molecular Docking Studies

Abstract Indole-thiosemicarbazones have different biological activities. The present study evaluated the preliminary interaction of these compounds with biomolecules, specifically human serum albumin (HSA) and DNA, using fluorescence techniques. The suppression results (Ksv) for HSA ranged from 3.5...

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Main Authors: Keriolaine Lima dos Santos, Diego Santa Clara Marques, Iris Trindade Jacob, Paula Roberta da Silva, Dijanah Cota Machado, Túlio Ricardo Couto de Lima Souza, Jamerson Ferreira de Oliveira, Sinara Mônica Vitalino Almeida, Iranildo José da Cruz Filho, Maria do Carmo Alves de Lima
Format: Article
Language:English
Published: Instituto de Tecnologia do Paraná (Tecpar) 2025-05-01
Series:Brazilian Archives of Biology and Technology
Subjects:
thiosemicarbazone
interaction
macromolecules.
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132025000100402&lng=en&tlng=en
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