A Two-Photon Zn(II) Complex Photosensitizer with pH/Viscosity Dual Response for Enhanced Tumor Therapy
In recent years, an increasing number of studies have shown that novel metal complexes with bio-imaging capabilities could enhance precision oncology, particularly through optimized photosensitizer (PS) design for subcellular organelle targeting photodynamic therapy (PDT). Based on this, we successf...
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MDPI AG
2025-05-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/30/11/2430 |
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| author | Yu Zhang Shao-Qi Guan Ya-Ping Wang Mei Pan |
| author_facet | Yu Zhang Shao-Qi Guan Ya-Ping Wang Mei Pan |
| author_sort | Yu Zhang |
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| description | In recent years, an increasing number of studies have shown that novel metal complexes with bio-imaging capabilities could enhance precision oncology, particularly through optimized photosensitizer (PS) design for subcellular organelle targeting photodynamic therapy (PDT). Based on this, we successfully developed a two-photon (TP) fluorescent Zn(II) complex, LIFM–ZY–3, characterized by the specifical targeting capability of lysosome. This complex was capable of monitoring dual changes in pH and viscosity. Additionally, our findings indicated that the complex could generate multiple reactive oxygen species (ROS), including singlet oxygen (<sup>1</sup>O<sub>2</sub>), hydroxyl radicals (•OH), and superoxide anion radicals (O<sub>2</sub><sup>−</sup>) under white light irradiation in vivo and in vitro. These findings underscored the remarkable versatility of LIFM–ZY–3 as an advanced multifunctional PS for both microenvironment monitoring and tumor therapy. |
| format | Article |
| id | doaj-art-2e944c7cfe33466c95e95ffacacd47bd |
| institution | Kabale University |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
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| series | Molecules |
| spelling | doaj-art-2e944c7cfe33466c95e95ffacacd47bd2025-08-20T03:46:50ZengMDPI AGMolecules1420-30492025-05-013011243010.3390/molecules30112430A Two-Photon Zn(II) Complex Photosensitizer with pH/Viscosity Dual Response for Enhanced Tumor TherapyYu Zhang0Shao-Qi Guan1Ya-Ping Wang2Mei Pan3MOE Laboratory of Bioinorganic and Synthetic Chemistry, Lehn Institute of Functional Materials, IGCME, GBRCE for Functional Molecular Engineering, School of Chemistry, Sun Yat-sen University, Guangzhou 510006, ChinaMOE Laboratory of Bioinorganic and Synthetic Chemistry, Lehn Institute of Functional Materials, IGCME, GBRCE for Functional Molecular Engineering, School of Chemistry, Sun Yat-sen University, Guangzhou 510006, ChinaMOE Laboratory of Bioinorganic and Synthetic Chemistry, Lehn Institute of Functional Materials, IGCME, GBRCE for Functional Molecular Engineering, School of Chemistry, Sun Yat-sen University, Guangzhou 510006, ChinaMOE Laboratory of Bioinorganic and Synthetic Chemistry, Lehn Institute of Functional Materials, IGCME, GBRCE for Functional Molecular Engineering, School of Chemistry, Sun Yat-sen University, Guangzhou 510006, ChinaIn recent years, an increasing number of studies have shown that novel metal complexes with bio-imaging capabilities could enhance precision oncology, particularly through optimized photosensitizer (PS) design for subcellular organelle targeting photodynamic therapy (PDT). Based on this, we successfully developed a two-photon (TP) fluorescent Zn(II) complex, LIFM–ZY–3, characterized by the specifical targeting capability of lysosome. This complex was capable of monitoring dual changes in pH and viscosity. Additionally, our findings indicated that the complex could generate multiple reactive oxygen species (ROS), including singlet oxygen (<sup>1</sup>O<sub>2</sub>), hydroxyl radicals (•OH), and superoxide anion radicals (O<sub>2</sub><sup>−</sup>) under white light irradiation in vivo and in vitro. These findings underscored the remarkable versatility of LIFM–ZY–3 as an advanced multifunctional PS for both microenvironment monitoring and tumor therapy.https://www.mdpi.com/1420-3049/30/11/2430Zn(II) complexTP fluorescencedual monitoringROSPDT |
| spellingShingle | Yu Zhang Shao-Qi Guan Ya-Ping Wang Mei Pan A Two-Photon Zn(II) Complex Photosensitizer with pH/Viscosity Dual Response for Enhanced Tumor Therapy Molecules Zn(II) complex TP fluorescence dual monitoring ROS PDT |
| title | A Two-Photon Zn(II) Complex Photosensitizer with pH/Viscosity Dual Response for Enhanced Tumor Therapy |
| title_full | A Two-Photon Zn(II) Complex Photosensitizer with pH/Viscosity Dual Response for Enhanced Tumor Therapy |
| title_fullStr | A Two-Photon Zn(II) Complex Photosensitizer with pH/Viscosity Dual Response for Enhanced Tumor Therapy |
| title_full_unstemmed | A Two-Photon Zn(II) Complex Photosensitizer with pH/Viscosity Dual Response for Enhanced Tumor Therapy |
| title_short | A Two-Photon Zn(II) Complex Photosensitizer with pH/Viscosity Dual Response for Enhanced Tumor Therapy |
| title_sort | two photon zn ii complex photosensitizer with ph viscosity dual response for enhanced tumor therapy |
| topic | Zn(II) complex TP fluorescence dual monitoring ROS PDT |
| url | https://www.mdpi.com/1420-3049/30/11/2430 |
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