Nukleophile Acylierung über Glycidnitrile
Carbonylcompounds 1, 2-chloroacrylonitrile and alkoxides react in a three-component-condensation with formation of glycidonitriles 2. 2-Cyclohexylidenexpoxi-3-methoxy-propionitrile 5 e. g. is obtained in 85% yield from cyclohexanone, 2-chloroacrylonitrile and sodium-methoxide. Glycidonitriles are u...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | deu |
| Published: |
Swiss Chemical Society
1975-11-01
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| Series: | CHIMIA |
| Online Access: | https://www.chimia.ch/chimia/article/view/9251 |
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| Summary: | Carbonylcompounds 1, 2-chloroacrylonitrile and alkoxides react in a three-component-condensation with formation of glycidonitriles 2. 2-Cyclohexylidenexpoxi-3-methoxy-propionitrile 5 e. g. is obtained in 85% yield from cyclohexanone, 2-chloroacrylonitrile and sodium-methoxide. Glycidonitriles are useful intermediates for the synthesis of α,α'-difunctionalised ketones. 5 e. g. is easily transformed into the corresponding α-methoxy-α'-hydroxyketone 8, the α-inethoxy-α',β'-unsaturated ketone 9, the α-methoxy-α'-chloroketone 10, the α-methoxyketone 11 as well as the butenolide 12.
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| ISSN: | 0009-4293 2673-2424 |