Sudden cardiac death associated with fatty liver disease
Background: Fatty liver disease or steatotic liver disease (SLD) affects 25% of the global population and has been associated with heart disease. However, there is a lack of postmortem studies in the context of sudden cardiac death (SCD). Objectives: To investigate the relationship between SLD and S...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | International Journal of Cardiology: Heart & Vasculature |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352906725000053 |
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| author | Jonathan Vo Thien T.T.T. Truyen Audrey Uy-Evanado Arayik Sargsyan Harpriya Chugh Christopher Young Sean Hurst Christina Y. Miyake Kyndaron Reinier Sumeet S. Chugh |
| author_facet | Jonathan Vo Thien T.T.T. Truyen Audrey Uy-Evanado Arayik Sargsyan Harpriya Chugh Christopher Young Sean Hurst Christina Y. Miyake Kyndaron Reinier Sumeet S. Chugh |
| author_sort | Jonathan Vo |
| collection | DOAJ |
| description | Background: Fatty liver disease or steatotic liver disease (SLD) affects 25% of the global population and has been associated with heart disease. However, there is a lack of postmortem studies in the context of sudden cardiac death (SCD). Objectives: To investigate the relationship between SLD and SCD. Methods: A post-mortem case-case study was conducted in victims of SCD from an ongoing community-based study in Southern California (Ventura, CA, 2015–2023). Diagnosis of SLD was determined from post-mortem liver histopathology reports. For each patient, demographic variables, laboratory values, and presence of co-morbidities were ascertained from medical records and were compared between patients with and without SLD. Results: Of 162 individuals with SCD, there were 101 SLD cases and 61 without SLD. Individuals with SLD were found to have higher BMI (31.6 ± 7.6 vs. 26.7 ± 5.7, p < 0.001), higher prevalence of heavy drinking (28 % vs. 12 %, p = 0.008), heavier liver weights (2433.6 g ± 940.6 vs 1934.7 g ± 505.3, p < 0.001), and were more often Hispanic (37 vs. 18 %, p = 0.01). Patients with SLD had lower prevalence of coronary artery disease (CAD) (49 % vs. 70 %). Multivariable logistic regression analysis showed that CAD was a negative predictor of SCD with SLD (OR = 0.35, 95 % CI 0.14 – 0.83). Conclusion: Among adults with SCD, SLD was associated with higher prevalence of Hispanic ethnicity and lower prevalence of CAD. Given the major rise in SLD burden, these ethnicity-based differences as well as the specific nature of non-ischemic SCD etiologies warrant urgent further investigation. |
| format | Article |
| id | doaj-art-2e8f902fe4ad42cc8bb65b20176f4e17 |
| institution | DOAJ |
| issn | 2352-9067 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Cardiology: Heart & Vasculature |
| spelling | doaj-art-2e8f902fe4ad42cc8bb65b20176f4e172025-08-20T03:11:06ZengElsevierInternational Journal of Cardiology: Heart & Vasculature2352-90672025-02-015610160210.1016/j.ijcha.2025.101602Sudden cardiac death associated with fatty liver diseaseJonathan Vo0Thien T.T.T. Truyen1Audrey Uy-Evanado2Arayik Sargsyan3Harpriya Chugh4Christopher Young5Sean Hurst6Christina Y. Miyake7Kyndaron Reinier8Sumeet S. Chugh9Center for Cardiac Arrest Prevention, Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Health System, Los Angeles, CA, USACenter for Cardiac Arrest Prevention, Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Health System, Los Angeles, CA, USACenter for Cardiac Arrest Prevention, Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Health System, Los Angeles, CA, USACenter for Cardiac Arrest Prevention, Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Health System, Los Angeles, CA, USACenter for Cardiac Arrest Prevention, Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Health System, Los Angeles, CA, USAVentura County Health Care Agency, Ventura, CA, USAOregon State Medical Examiner’s Office, USADepartment of Pediatrics, Texas Children’s Hospital, USA; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, USACenter for Cardiac Arrest Prevention, Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Health System, Los Angeles, CA, USACenter for Cardiac Arrest Prevention, Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Health System, Los Angeles, CA, USA; Corresponding author at: The Smidt Heart Institute, Bard Pavilion, Suite A3100, 127 S. San Vicente Blvd., Los Angeles, CA 90048, USA.Background: Fatty liver disease or steatotic liver disease (SLD) affects 25% of the global population and has been associated with heart disease. However, there is a lack of postmortem studies in the context of sudden cardiac death (SCD). Objectives: To investigate the relationship between SLD and SCD. Methods: A post-mortem case-case study was conducted in victims of SCD from an ongoing community-based study in Southern California (Ventura, CA, 2015–2023). Diagnosis of SLD was determined from post-mortem liver histopathology reports. For each patient, demographic variables, laboratory values, and presence of co-morbidities were ascertained from medical records and were compared between patients with and without SLD. Results: Of 162 individuals with SCD, there were 101 SLD cases and 61 without SLD. Individuals with SLD were found to have higher BMI (31.6 ± 7.6 vs. 26.7 ± 5.7, p < 0.001), higher prevalence of heavy drinking (28 % vs. 12 %, p = 0.008), heavier liver weights (2433.6 g ± 940.6 vs 1934.7 g ± 505.3, p < 0.001), and were more often Hispanic (37 vs. 18 %, p = 0.01). Patients with SLD had lower prevalence of coronary artery disease (CAD) (49 % vs. 70 %). Multivariable logistic regression analysis showed that CAD was a negative predictor of SCD with SLD (OR = 0.35, 95 % CI 0.14 – 0.83). Conclusion: Among adults with SCD, SLD was associated with higher prevalence of Hispanic ethnicity and lower prevalence of CAD. Given the major rise in SLD burden, these ethnicity-based differences as well as the specific nature of non-ischemic SCD etiologies warrant urgent further investigation.http://www.sciencedirect.com/science/article/pii/S2352906725000053Sudden cardiac deathFatty liver diseaseCoronary artery diseaseHealthcare disparities |
| spellingShingle | Jonathan Vo Thien T.T.T. Truyen Audrey Uy-Evanado Arayik Sargsyan Harpriya Chugh Christopher Young Sean Hurst Christina Y. Miyake Kyndaron Reinier Sumeet S. Chugh Sudden cardiac death associated with fatty liver disease International Journal of Cardiology: Heart & Vasculature Sudden cardiac death Fatty liver disease Coronary artery disease Healthcare disparities |
| title | Sudden cardiac death associated with fatty liver disease |
| title_full | Sudden cardiac death associated with fatty liver disease |
| title_fullStr | Sudden cardiac death associated with fatty liver disease |
| title_full_unstemmed | Sudden cardiac death associated with fatty liver disease |
| title_short | Sudden cardiac death associated with fatty liver disease |
| title_sort | sudden cardiac death associated with fatty liver disease |
| topic | Sudden cardiac death Fatty liver disease Coronary artery disease Healthcare disparities |
| url | http://www.sciencedirect.com/science/article/pii/S2352906725000053 |
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