Papillomas and carcinomas of the choroid plexus: histological and immunohistochemical studies and comparison with normal fetal choroid plexus
BACKGROUND: Choroid plexus tumors are rare. Results on immunohistochemical features are scanty and controversial even regarding normal plexus. METHOD: Thirteen cases of choroid plexus tumors and five samples of normal fetal choroid plexus were submitted to immunohistochemical study using a panel of...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Thieme Revinter Publicações
2004-09-01
|
| Series: | Arquivos de Neuro-Psiquiatria |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2004000400007&tlng=en |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850236864074612736 |
|---|---|
| author | Ana Silvia Carvalho de Menezes Barreto José Vassallo Luciano de Souza Queiroz |
| author_facet | Ana Silvia Carvalho de Menezes Barreto José Vassallo Luciano de Souza Queiroz |
| author_sort | Ana Silvia Carvalho de Menezes Barreto |
| collection | DOAJ |
| description | BACKGROUND: Choroid plexus tumors are rare. Results on immunohistochemical features are scanty and controversial even regarding normal plexus. METHOD: Thirteen cases of choroid plexus tumors and five samples of normal fetal choroid plexus were submitted to immunohistochemical study using a panel of epithelial, neuronal and stromal markers. RESULTS/CONCLUSIONS: Relevant histological findings were presence of clear cells in 3/5 papillomas (PP) and 7/8 carcinomas (CA) and all 5 fetal plexuses; rhabdoid cells, desmoplasia and vascular proliferation were found respectively in 3, 4 and 5 cases out of 6 poorly differentiated CA and were absent in PP and well differentiated CA. Pancytokeratin AE1/AE3 was strongly positive in all 13 cases, even in the undifferentiated component of poorly differentiated CA, where reactivity was focal in 3 and diffuse in 3 cases. Low molecular weight cytokeratin (35bH11) was not expressed in any of the 8 CA, but was present in all 5 PP. In 4 of 6 poorly differentiated CA there was reactivity for smooth muscle actin (1A4) in 10 to 30% of the cells. This was true also for one case lacking rhabdoid cells. Laminin was undetectable in all 6 cases of poorly differentiated CA but was present in 4 PP and 2 well differentiated CA. All 5 fetal plexuses expressed GFAP. |
| format | Article |
| id | doaj-art-2e8d3ec842024374a3e63a9fd9cd3996 |
| institution | OA Journals |
| issn | 1678-4227 |
| language | English |
| publishDate | 2004-09-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-2e8d3ec842024374a3e63a9fd9cd39962025-08-20T02:01:53ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-42272004-09-01623a60060710.1590/S0004-282X2004000400007Papillomas and carcinomas of the choroid plexus: histological and immunohistochemical studies and comparison with normal fetal choroid plexusAna Silvia Carvalho de Menezes Barreto0José Vassallo1Luciano de Souza Queiroz2Universidade Estadual de CampinasUniversidade Estadual de CampinasUniversidade Estadual de CampinasBACKGROUND: Choroid plexus tumors are rare. Results on immunohistochemical features are scanty and controversial even regarding normal plexus. METHOD: Thirteen cases of choroid plexus tumors and five samples of normal fetal choroid plexus were submitted to immunohistochemical study using a panel of epithelial, neuronal and stromal markers. RESULTS/CONCLUSIONS: Relevant histological findings were presence of clear cells in 3/5 papillomas (PP) and 7/8 carcinomas (CA) and all 5 fetal plexuses; rhabdoid cells, desmoplasia and vascular proliferation were found respectively in 3, 4 and 5 cases out of 6 poorly differentiated CA and were absent in PP and well differentiated CA. Pancytokeratin AE1/AE3 was strongly positive in all 13 cases, even in the undifferentiated component of poorly differentiated CA, where reactivity was focal in 3 and diffuse in 3 cases. Low molecular weight cytokeratin (35bH11) was not expressed in any of the 8 CA, but was present in all 5 PP. In 4 of 6 poorly differentiated CA there was reactivity for smooth muscle actin (1A4) in 10 to 30% of the cells. This was true also for one case lacking rhabdoid cells. Laminin was undetectable in all 6 cases of poorly differentiated CA but was present in 4 PP and 2 well differentiated CA. All 5 fetal plexuses expressed GFAP.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2004000400007&tlng=enchoroid plexus tumorsnormal fetal choroid plexusimmunohistochemistrycentral nervous system |
| spellingShingle | Ana Silvia Carvalho de Menezes Barreto José Vassallo Luciano de Souza Queiroz Papillomas and carcinomas of the choroid plexus: histological and immunohistochemical studies and comparison with normal fetal choroid plexus Arquivos de Neuro-Psiquiatria choroid plexus tumors normal fetal choroid plexus immunohistochemistry central nervous system |
| title | Papillomas and carcinomas of the choroid plexus: histological and immunohistochemical studies and comparison with normal fetal choroid plexus |
| title_full | Papillomas and carcinomas of the choroid plexus: histological and immunohistochemical studies and comparison with normal fetal choroid plexus |
| title_fullStr | Papillomas and carcinomas of the choroid plexus: histological and immunohistochemical studies and comparison with normal fetal choroid plexus |
| title_full_unstemmed | Papillomas and carcinomas of the choroid plexus: histological and immunohistochemical studies and comparison with normal fetal choroid plexus |
| title_short | Papillomas and carcinomas of the choroid plexus: histological and immunohistochemical studies and comparison with normal fetal choroid plexus |
| title_sort | papillomas and carcinomas of the choroid plexus histological and immunohistochemical studies and comparison with normal fetal choroid plexus |
| topic | choroid plexus tumors normal fetal choroid plexus immunohistochemistry central nervous system |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2004000400007&tlng=en |
| work_keys_str_mv | AT anasilviacarvalhodemenezesbarreto papillomasandcarcinomasofthechoroidplexushistologicalandimmunohistochemicalstudiesandcomparisonwithnormalfetalchoroidplexus AT josevassallo papillomasandcarcinomasofthechoroidplexushistologicalandimmunohistochemicalstudiesandcomparisonwithnormalfetalchoroidplexus AT lucianodesouzaqueiroz papillomasandcarcinomasofthechoroidplexushistologicalandimmunohistochemicalstudiesandcomparisonwithnormalfetalchoroidplexus |